Changes in the Pharmacokinetics of Gd-DTPA in Experimental Tumors after Charged Particle Radiation : Comparison with γ-Ray Radiation

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概要

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• We performed dynamic MRI to reveal the characteristic gadopentetate dimeglumine (Gd-DTPA) uptake in carbon-ion irradiated tumor and compare it with photon irradiation. Fibrosarcomas in C3H mice legs were irradiated with either 16 Gy of carbon ions (74 keV/mm) or an equivalent dose (30 Gy) of Cs-137 γ-rays. Dynamic MRI was performed 1 or 6 days after irradiation when the tumors showed an initial growth delay or incipient regrowth, respectively. The enhancement pattern was visualized by mapping the maximum enhanced time (Tmax), relative signal intensity maximum (SImax), and time delay of starting enhancement (Td). Significantly larger Tmax and Td values were observed in the tumors 1 day after carbon-ion irradiation than in the nonradiated tumors (No-R) and tumors 1 day after γ-ray irradiation. Among the selected pixels in the tumors 6 days after carbon irradiation, 77% had Tmax values of less than 120 sec, significantly more than in the No-R group. The Tmax maps for the tumors irradiated with γ-rays showed a similar tendency to the carbon-irradiated ones, and only a significant difference was obtained between tumors 1 and 6 days after irradiation. Tmax and Td in the carbon-ion irradiated tumors were different from those in the γ-ray-irradiated tumors. These treatment-specific kinetics may be useful in predicting the therapeutic efficacy of carbon-ion treatment.

• 2004-06-15

著者

• ISHIKAWA Hitoshi

  Department of Radiation Oncology, Gunma University Graduate school of Medicine

• 安藤 興一

  放医研

• Suzuki Keiji

  Course Of Life Sciences And Radiation Research Graduate School Of Biomedical Sciences Nagasaki Unive

• Suzuki Keiji

  大阪府立大学先端科学イノベーションセンター 放射線生命科学

• 安藤 興一

  学振科技特

• 安藤 興一

  Natl. Instit. Rad. Sci. Med.

• TSUJII Hirohiko

  Research Center for Charged Particle Therapy, National Institute of Radiological Sciences

• Ando Koichi

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• Tanada Shuji

  Department of Medical Imaging, National Institute of Radiological Sciences

• 小池 幸子

  北里大学 獣医学部

• Sasai Keisuke

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• KOIKE Sachiko

  Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Instit

• Ando K

  Division Of Health Sciences Graduate School Of Medicine Osaka University

• Kodama S

  Radiation Biology Laboratory Radiation Research Center Frontier Science Innovation Center Organizati

• Ando Koichi

  Heavy-ion Radiobiology Res. Group National Inst. Of Radiological Sciences

• Kodama Seiji

  Division Of Radiation Biology And Health Science Research Center For Radiation And Radioisotopes Res

• Tanada Shuji

  Department Of Medical Imaging National Institute Of Radiological Sciences

• Shibuya Keiko

  Department Of Radiation Oncology And Image-applied Therapy Kyoto University Hospital

• Koike Sachiko

  Heavy-ion Radiobiology Res. Group National Inst. Of Radiological Sciences

• Sasai Keisuke

  京都大学 放射腺腫瘍学･画像応用療学

• Obata Takayuki

  Department Of Medical Imaging National Institute Of Radiological Sciences

• Tsujii Hirohiko

  Research Center For Charged Particle Therapy National Institute Of Radiological Sciences

• IKEHIRA Hiroo

  Department of Medical Imaging, National Institute of Radiological Sciences

• KOIKE Sachiko

  National Inst. of Radiol. Sci

• Ikehira H

  Department Of Medical Imaging National Institute Of Radiological Sciences

• Ikehira Hiroo

  Division Of Advanced Technology For Medical Imaging Research Center Of Charged Particle Technique Na

• Ando Soichiro

  National Institute Of Radiological Sciences

• Ando Koichi

  Department Of Technical Support And Development Natl. Inst. Radiol. Sci.

• Ando Koichi

  Space And Particle Radiation Science Research Group National Institute Of Radiological Sciences

• Koike Sachiko

  Research Center For Charged Particle Therapy Natl. Inst. Radiol. Sci.

• Ando Koichi

  Division Of Health Sciences Graduate School Of Medicine Osaka University

• Oohira Chisa

  放射線医学総合研究所

• Oohira Chisa

  Radgenomics Project National Institute Of Radiological Sciences

• Ohira Chisa

  Radgenomics Project Frontier Research Center National Institute Of Radiological Sciences

• Hirama Toshiyasu

  Research Center For Charged Particle Therapy National Institute Of Radiological Sciences

• Sasai Keisuke

  Department Of Radilogy And Nuclear Medicine Faculty Of Medicine Kyoto University

• Ikehira Hiroo

  Department Of Medical Imaging National Institute Of Radiological Sciences

• Kasai Soko

  Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe

• Kasai Soko

  Department Of Biological Science And Technology Faculty Of Engineering University Of Tokushima

• Koike Sachiko

  Heavy-ion Radiobiology Research Group Research Center For Charged Particle Therapy National Institut

• OOHIRA Chisa

  Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences

• YASUDA Hiroshi

  Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences

• Obata T

  Dep. Of Radiation Oncology Gunma Univ. Graduate School Of Medicine

• Tanada S

  Department Of Medical Imaging National Institute Of Radiological Sciences

• Obata Takayuki

  Department Of Biophysics Molecular Imaging Center National Institute Of Radiological Sciences

• Ando Koichi

  Heavy-ion Radio. Res. Nirs

• Ando Koichi

  International Space Radiation Laboratory National Institute Of Radiological Sciences

• Yasuda Hiroshi

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

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