Delayed Induction of Telomere Instability in Normal Human Fibroblast Cells by Ionizing Radiation

スポンサーリンク

概要

• 論文の詳細を見る

• We examined the delayed induction of telomere instability in hTERT-immortalized normal human fibroblast (BJl-hTERT) cells exposed to X-rays. BJl-hTERT cells were irradiated with 2 Gy of X-rays, and chromosome aberrations were analyzed 24 hours after irradiation and in the surviving cells 14 days after X-ray exposure. We found that the X-ray-surviving cells showed an increased frequency of chromatid gaps and breaks and chromosome fragments compared to the control cells. Furthermore, centromere- and telomere-FISH revealed that the frequency of telomere loss and duplication significantly increased in surviving cells compared to the control level. Because no induction of telomere abnormality was observed in cells 24 hours after irradiation, X-irradiation might not affect telomeres directly, but it specifically induces delayed telomere instability in normal human fibroblast cells.

• 日本放射線影響学会の論文

著者

• Suzuki Keiji

  Course Of Life Sciences And Radiation Research Graduate School Of Biomedical Sciences Nagasaki Unive

• Suzuki Keiji

  大阪府立大学先端科学イノベーションセンター 放射線生命科学

• Suzuki Minoru

  Particle Radiation Oncology Research Center Kyoto University

• Suzuki Keiji

  Division Of Radiation Biology Department Of Radiology And Radiation Biology Graduate School Of Biome

• Kodama Seiji

  京都大学原子炉実験所 粒子線生物学研究分野

• Kodama Seiji

  長崎大学 医歯薬学総合研究科放射線生物学

• Suzuki M

  Particle Radiation Oncology Research Center Kyoto University

• Watanabe Masami

  Particle Radiation Biology Research Reactor Institute Kyoto University

• Kodama S

  Radiation Biology Laboratory Radiation Research Center Frontier Science Innovation Center Organizati

• Mori Sao

  Lab. Radiat. Life Sci. Schi. Pharm. Sci. Nagasaki Univ.

• Kodama Seiji

  Division Of Radiation Biology And Health Science Research Center For Radiation And Radioisotopes Res

• Hamano Hiroki

  Division Of Radiation Biology Department Of Radiology And Radiation Biology Course Of Life Sciences

• Oshimura M

  Tottori Univ. Yonago Jpn

• Oshimura Mitsuo

  鳥取大学 医学部分子細胞生物学講座ゲノム医工学分野

• Oshimura Mitsuo

  Dep. Of Biomedical Sci. Inst. Of Regenerative Medicine And Biofunction Graduate School Of Medical Sc

• OJIMA Mitsuaki

  Division of Radiation Biology, Department of Radiology and Radiation Biology, Course of Life Science

• SUZUKI Masatoshi

  Division of Radiation Biology, Department of Radiology and Radiation Biology, Course of Life Science

• WATANABE Masami

  Division of Radiation Biology, Department of Radiology and Radiation Biology, Course of Life Science

• Suzuki Masao

  National Inst. Radiological Sci. Chiba Jpn

• Suzuki Masao

  Heavy-ion Radiobiology Res. Group National Inst. Radiological Sciences

• Watanabe Masani

  National Institute Of Basic Biology (nibb)

• Ojima Mitsuaki

  Division Of Molecular Genetics And Biofunction Department Of Biomedical Science Institute Of Regener

• Watanabe Masami

  京都大学原子炉実験所 粒子線生物学研究分野

• Watanabe M

  Particle Radiation Biology Research Reactor Institute Kyoto University

• Kasai Soko

  Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe

• Kasai Soko

  Department Of Biological Science And Technology Faculty Of Engineering University Of Tokushima

• Watanabe Masani

  Division Of Radiation Biology Faculty Of Pharmacology Of Science Nagasaki University

• Suzuki K

  Division Of Radiation Biology Department Of Radiology And Radiation Biology Course Of Life Sciences

• Kasai Soko

  Course Of Life Sciences And Radiation Research Graduate School Of Biomedical Sciences Nagasaki Unive

• Watanabe Masami

  Lab. Of Radiation Biology Div. Of Radiation Life Sci. Res. Reactor Inst. Kyoto Univ.

• Suzuki Keiji

  Division Of Applied Biology Faculty Of Textile Science And Technology Shinshu University

• Suzuki Minoru

  Particle Oncology Research Center Research Reactor Institute Kyoto University

• Watanabe Masami

  Division Of Radiation Biology School Of Medicine Yokohama City University

関連論文

• Changes in the Sensitivity of Intratumor Cells during Fractionated Tirapazamine Administration
• Usefulness of Tirapazamine as a Combined Agent in Chemoradiation and Thermo-chemoradiation Therapy at Mild Temperatures: Reference to the Effect on Intratumor Quiescent Cells
• Potentially Lethal Damage Repair by Total and Quiescent Tumor Cells Following Various DNA-damaging Treatments
• Enhancement of Cisplatin Sensitivity of Quiescent Cells in Solid Tumors by Combined Treatment with Tirapazamine and Low-Temperature Hyperthermia
• Effective Suppression of Bystander Effects by DMSO Treatment of Irradiated CHO Cells
• Responses of total and quiescent cell populations in solid tumors to carbon ion beam irradiation (290 MeV/u) in vivo
• Absence of G1 arrest after X-ray irradiation in cancer cells with wild-type p53
• Biological effect of radiation-induced long life radicals
• Changes in the Pharmacokinetics of Gd-DTPA in Experimental Tumors after Charged Particle Radiation : Comparison with γ-Ray Radiation
• Repair of Skin Damage During Fractionated Irradiation with Gamma Rays and Low-LET Carbon Ions
• Biological Gain of Carbon-ion Radiotherapy for the Early Response of Tumor Growth Delay and against Early Response of Skin Reaction in Mice
• 269 Significance of beta term in carbon-ion radiotherapy(Bases of radiotherapy, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 265 Relationship between RBE values of Carbon Ion and Tumor Growth Rate(Bases of radiotherapy, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Radioprotective Effects of Beer on Radiation-Induced Acute Toxicity in Mice
• Dependence of Gut-crypt Sensitivity on the Time Interval between Two Fractions of Carbon Ion Radiation
• Tumor Growth Rate and RBE values of high LET Carbon Ions
• Dependence of Carbon-Ion RBE on Dose Size -Difference between Skin and Tumors
• Relative Biological Effectiveness of 290 MeV/u Carbon Ions for the Growth Delay of a Radioresistant Murine Fibrosarcoma
• RBE of Carbon Ions for Tumor Growth Delay
• Fractionated irradiation with carbon ions induced resistance in mouse gut crypt cells
• Relative Biological Effectiveness of the 235 MeV Proton Beams at the National Cancer Center Hospital East
• Effects of sequentially mixed LET on tumor growth delay
• Fractionated irradiation with carbon ions to gut intestinal crypt cells
• Tumor Induction in Mice Locally Irradiated with Carbon Ions : A Retrospective Analysis
• Introduction of a Normal Human Chromosome 8 Corrects Abnormal Phenotypes of Werner Syndrome Cells Immortalized by Expressing an hTERT Gene
• Delayed Induction of Telomere Instability in Normal Human Fibroblast Cells by Ionizing Radiation
• 226 Radiation-induced delayed chromosomal instability caused by large deletion(Genetic instability, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 223 Radiation-Induced Delayed Chromosomal Instability(Genetic instability, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 221 A Role of DNA Double Strand Break Repair in the Induction of Genetic Instability(Genetic instability, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 214 The complementation of abnormal phenotypes of Werner syndrome cells by expressing WRN gene(Physics, chemistry and DNA damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• S-2-3 Radiation-Induced Delayed Chromosome Aberrations(Radiation Induced Genetical Instability : What Is the Mechanism That a Cell Memorizes Being Irradiated?, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Instability of a Human Chromosome Exposed to Radiation in Unirradiated Mouse Cells
• The Role of DNA-PKcs Function on Induction of Genetic Instability by Radiation
• Radiation-induced genomic instability caused by large deletion (position)
• Thermosensitization by Inhibition of Gap Junctional Intercellular Communication
• Phenotypic Reversion of an X-Ray-Induced Transformant of Mouse m5S by Introduction of a Human Chromosome 11
• The Effect of DNA Repair Defects on the Induction of Delayed Chromosome Aberrations by Radiation
• Involvement of Telonomic Instability in the Formation of Delayed Chromosome Aberrations Induced by Radiation
• Tumor Vasculature and PO2 Distributions Depend on Implantation Site
• Morphometric Evaluation of Late Normal Tissue Damage after Neon Beam Irradiation in Mouse Hind Legs
• Effects of fractionated irradiation with carbon ions on the NFSa fibrosarcoma in mice
• Adjuvant Radiation Therapy Following Mastectomy for Breast Cancer
• Evidence for Induction of DNA Double Strand Breaks in the Bystander Response to Targeted Soft X-Rays in Repair Deficient CHO Cells
• Apoptosis Induction in the NFSa tumor after irradiation with carbon ions
• Increased Chromosome Instability and Accumulation of DNA Double-strand Breaks in Werner Syndrome Cells
• Biochemical Markers for in Situ Detection of DNA Double Strand Breaks in Cultured Mammalian Cells
• Exogenous Expression of Exonuclease Domain-deleted WRN Interferes with the Repair of Radiation-induced DNA Damages
• Differences in Effects of Oncogenes on Sensitivity to Anticancer Drugs
• Involvement of Reactive Oxygen Species (ROS) in the Induction of Genetic Instability by Radiation
• 225 Influence of Reactive Oxygen Species in the Induction of Genetic Instability by Radiation(Genetic instability, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 222 X-ray-induced genomic instability in Atm knock-out mouse cells(Genetic instability, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 220 Mechanism of radiation-induced delayed mutagenesis(Genetic instability, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 217 Localization of Phosphorylated H2AX and Phosphorylated p53 in Cells Inducing X-ray-induced Senescence-like Growth Arrest(Physics, chemistry and DNA damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 168 Mechanism of cell cycle-dependent cell death by heat shock(Radio-protection and sensitization, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 141 The role of site-specific phosphorylation on X-ray-induced p53 accumulation(Redox regulation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Response of Mouse Intestine to Carbon-12 Beams in Relation to Dose Fraction and Effects of Steroids on Radiation-Induced Intestinal Damages
• 104 DNA Damage-Induced Phosphorylation of Histone H2AX and Alteration of Chromatin Structure(Repair of radiation damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 97 A Role of WRN Protein in the Recovery from DNA Replication Arrest(Repair of radiation damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Induction of Micronuclei in CHO Cells by Bleomycin but not by X-irradiation is Decreased by Treatment with HMG-CoA Reductase Inhibitors
• Involvement of reactive oxygen species (ROS) in the induction of genetic instability by radiation
• Relationship between dysfunction of WRN protein and radiosensitivity
• Role of WRN exonuclease in repair of DNA double strand breaks
• Characterization of X-ray-induced Mutation in Werner Syndrome Cells
• Analysis of X-Ray-Induced Mutation in Werner Syndrome Cells
• Effects of Beer Administration in Mice on Acute Toxicities Induced by X Rays and Carbon Ions
• Differences in pO_2 Peaks of a Murine Fibrosarcoma between Carbon-ion and X-ray Irradiation
• 267 Early Change of ^C-Thymidine Uptake after Carbon-beam Irradiation in Experimental Tumors(Bases of radiotherapy, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Enhancement of the relative uptake of F-FDG in mouse fibrosarcoma by rolipram
• Tumor induction in mouse legs after irradiation with heavy ions
• Phosphorylated ATM Foci as a Biochemical Marker for DNA Double Strand Breaks
• Mechanism of radiation-induced delayed mutagenesis
• Delayed Induction of DNA Damage and Activation of p53 in X-ray Surviving Cells
• Participation of ATM function in X-ray-induced delayed chromosomal instability
• Biological Action of Curcumin on Transformed Mouse Cells
• Biological Action of Curcumin on Transformed Mouse Cells
• Role of Ser15, Thr18, and Ser20 phosphorylation in p53 stabilization after X-irradiation
• X-rays-induced phosphorylation of H2AX in mitotic cells
• The role of telomerase activity in the radiation carcinogenesis processes of normal human cells
• Suppressive Effect of p53 on Heat-induced Multiple Centrosomes
• In vitro transformation system using hTERT-transfected normal human diploid cells
• Radiation-induced delayed damage in scid mouse cells
• Mechanism of p53 Accumulation and Activation by Ionizing Radiation and Telomere Shortening
• Recovery of clonogenic tumor cells after irradiation with carbon ions
• 211 Effect of RibCys on scavenging long-lived radicals and reducing gene mutation in mammalian cells by adding AFTER irradiation(Physics, chemistry and DNA damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Inhibitory Effect of Curcumin on the Growth of Transformed Mouse Cells
• Involvement of Long-Lived Radicals Induced by Radiation in the Induction of Mutation
• Suppression of Radiation-Induced Mutation by an Anti-Oxidant Material
• Induction of Gene Mutation and Cancer by Extra-DNA Bystander Effect of Long-lived Protein Radicals inGamma Ray Irradiated Mammalian Cells.
• Scavenging of long-lived radicals by (?)-epigallocatechin-3-O-gallate and simultaneous suppression of mutationin irradiated mammalian cells
• Direct Observation of Long-lived Radicals in Irradiated Mammalian Cells which Cause Mutation
• S-6-2 Long-Lived Radicals (LLR) Causes Genotoxic Effects(Biological Effects of Long-lived Radicals Induced by Radiation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Mechanism of delayed mutagenesis by radiation-induced genomic instability
• Enhanced Cell Proliferation by X-Irradiated Conditioned Medium
• Dose-dependent bi-phasic accumulation of p53 protein in normal human embryo cells following X-irradiation
• Radiation-Induced Genetic Instability in Scid Mouse Cells
• Radiation-Induced Delayed Chromosome Instability Studied by a Microcell-Mediated Chromosome Transfer
• Defective Accumulation of p53 Protein In X-irradiated Human Tumor Cells With Low Proteasome Activity
• Abnormal Radiosensitivity at G2 Phase in Werner Syndrome Cells and Its Complementation by Introduction of a Normal Human Chromosome 8
• X-ray-induced delayed damage in normal human embryo cells
• Activation of p53 suppresses mitotic catastrophe in response to ionizing radiation

もっと見る 閉じる

スポンサーリンク