Tumor Induction in Mice Locally Irradiated with Carbon Ions : A Retrospective Analysis

スポンサーリンク

概要

• 論文の詳細を見る

• Tumor induction in mice legs that were locally irradiated with carbon ions was compared to tumor induction by γ rays after single and fractionated irradiation. A total of 250 tumors were induced in 1104 mice that received carbon-ion doses of 5 through 65 Gy. A total of 77 tumors were induced in 371 mice that received γ-ray doses of 45 through 95 Gy. Of 91 carbon-ion induced tumors examined histologically, 97 percent were malignant, and sarcomas such as malignant fibrous histiocytoma (47%) and fibrosarcoma (32%) were most frequently observed. Malignant fibrous histiocytoma was also the most frequently observed tumor (12 out of 20 tumors; 60%) after γ-ray irradiation, followed by carcinomas (25%) such as adenocarcinoma and squamous cell carcinoma. Neither dose fractionation nor linear energy transfer affected tumor induction for carbon ions and γ rays. Dose responses were linear for carbon ions and γ rays, and showed no saturation up to 65 Gy of carbon ions and 95 Gy of γ rays. The relative biological effectiveness of carbon ions was 2.2 for tumor induction and 1.9 for early skin reaction. We conclude that risk of secondary tumor induction by carbon-ion radiotherapy would not be seriously higher than anticipated.

• 日本放射線影響学会の論文
• 2005-06-30

著者

• 安藤 興一

  放医研

• YATAGAI Fumio

  RIKEN Institute

• Suzuki Keiji

  Course Of Life Sciences And Radiation Research Graduate School Of Biomedical Sciences Nagasaki Unive

• Suzuki Keiji

  大阪府立大学先端科学イノベーションセンター 放射線生命科学

• 安藤 興一

  学振科技特

• 安藤 興一

  Natl. Instit. Rad. Sci. Med.

• Ando Koichi

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• 笹井 啓資

  新潟大学医学部放射線医学講座

• 小池 幸子

  北里大学 獣医学部

• YATAGAI Fumio

  IPCR

• Sasai Keisuke

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• OOHIRA Chisa

  RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences

• OGIU Toshiaki

  Low Dose Radiat. Eff. Res. Proj., NIRS

• KOIKE Sachiko

  Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Instit

• Ando K

  Division Of Health Sciences Graduate School Of Medicine Osaka University

• Kodama S

  Radiation Biology Laboratory Radiation Research Center Frontier Science Innovation Center Organizati

• Ando Koichi

  Heavy-ion Radiobiology Res. Group National Inst. Of Radiological Sciences

• Kodama Seiji

  Division Of Radiation Biology And Health Science Research Center For Radiation And Radioisotopes Res

• Oguri T

  Hiroshima Univ. Fac. Medicine Hiroshima

• Oguri Tetsuya

  Department Of Internal Medicine And Molecular Science Nagoya City University Graduate School Of Medi

• Oguri Tetsuya

  Second Department Of Internal Medicine Hiroshima University Faculty Of Medicine

• Shibuya Keiko

  Department Of Radiation Oncology And Image-applied Therapy Kyoto University Hospital

• Koike Sachiko

  Heavy-ion Radiobiology Res. Group National Inst. Of Radiological Sciences

• Sasai Keisuke

  京都大学 放射腺腫瘍学･画像応用療学

• Yatagai F

  Riken Saitama Jpn

• Yatagai Fumio

  Division Of Radioisotope Technology Riken

• Yatagai Fumio

  Inst. Phys. Chem. Res.

• Yatagai Fumio

  Division Of Radioisotope Technology The Institute Of Physical And Chemical Research

• Yatagai Fumio

  Ri Inst. Phys. Chem. Res.

• KOIKE Sachiko

  National Inst. of Radiol. Sci

• Ando Soichiro

  National Institute Of Radiological Sciences

• Ando Koichi

  Department Of Technical Support And Development Natl. Inst. Radiol. Sci.

• Ando Koichi

  Space And Particle Radiation Science Research Group National Institute Of Radiological Sciences

• Koike Sachiko

  Research Center For Charged Particle Therapy Natl. Inst. Radiol. Sci.

• Yatagai F

  Division Of Radioisotope Technology Riken

• Ando Koichi

  Division Of Health Sciences Graduate School Of Medicine Osaka University

• Oohira Chisa

  放射線医学総合研究所

• Oohira Chisa

  Radgenomics Project National Institute Of Radiological Sciences

• Ohira Chisa

  Radgenomics Project Frontier Research Center National Institute Of Radiological Sciences

• Sasai Keisuke

  Department Of Radilogy And Nuclear Medicine Faculty Of Medicine Kyoto University

• Kasai Soko

  Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe

• Kasai Soko

  Department Of Biological Science And Technology Faculty Of Engineering University Of Tokushima

• Koike Sachiko

  Heavy-ion Radiobiology Research Group Research Center For Charged Particle Therapy National Institut

• Yatagai Fumio

  理化学研究所

• Ogiu Toshiaki

  Low Dose Radiation Effects Research Project National Institute Of Radiological Sciences

• Ogiu Toshiaki

  Low Dose Effects Research Project National Institute Of Radiological Sciences

• Ogiu T

  National Institute Of Radiological Science

• Ogiu Toshiaki

  Low Dose Radiation Effect Project National Institute Of Radiological Sciences

• Ogiu Toshiaki

  Low Dose Radiat. Effect Project. Natl. Inst. Radiol. Sci.

• Yatagai F

  Riken Institute

• Oguri Tetsuya

  Department Of Medical Oncology And Immunology Nagoya City University Graduate School Of Medical Scie

• Ando Koichi

  Heavy-ion Radio. Res. Nirs

• Ando Koichi

  International Space Radiation Laboratory National Institute Of Radiological Sciences

関連論文

• An Approach to Estimate Radioadaptation from DSB Repair Efficiency
• LOH Analyses for Biological Effects of Space Radiation : Human Cell Culture in "Kibo" of International Space Station
• 382 ATCCS (Adhesive Tumor Cell Culture System) 法を用いた消化器癌の放射線感受性試験の検討(第41回日本消化器外科学会総会)
• 25.骨肉腫の放射線治療効果に関する研究第1報 : マウス実験骨肉腫におけるγ線および速中性子線の効果(第738回千葉医学会整形外科例会)
• A Comparison of Biological Responses of Human Tumor Cells After Irradiation with Heavy Ions and Neutrons
• 23.骨軟部悪性腫瘍に対する重粒子線治療の展望(第853回 千葉医学会整形外科例会)
• 343 放射線治療における腫瘍血管および酸素分圧分布の影響
• Effective Suppression of Bystander Effects by DMSO Treatment of Irradiated CHO Cells
• Responses of total and quiescent cell populations in solid tumors to carbon ion beam irradiation (290 MeV/u) in vivo
• 重粒子線で誘発されるクロマチン切断誘発のLET依存性
• ネオンイオンビームによる細胞死と突然変異誘発効果
• Changes in the Pharmacokinetics of Gd-DTPA in Experimental Tumors after Charged Particle Radiation : Comparison with γ-Ray Radiation
• Mutation Induction in Cultured Human Cells after Low-dose and Low-dose-rate γ-ray Irradiation : Detection by LOH Analysis
• Induction of LOH events by Low-dose or Low-dose Rate Radiation Exposure
• 22.C3Hマウス正常組織及び線維肉腫(NSFa)に対するEtoposideの腹腔内投与と放射線による修飾効果(第787回千葉医学会例会・第4回磯野外科例会)
• Protective Effects of Melatonin Against Low- and High-LET Irradiation
• Repair of Skin Damage During Fractionated Irradiation with Gamma Rays and Low-LET Carbon Ions
• Biological Gain of Carbon-ion Radiotherapy for the Early Response of Tumor Growth Delay and against Early Response of Skin Reaction in Mice
• 269 Significance of beta term in carbon-ion radiotherapy(Bases of radiotherapy, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 265 Relationship between RBE values of Carbon Ion and Tumor Growth Rate(Bases of radiotherapy, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 258 Different Responses of Malignant Melanomas and Squamous Cell Carcinomas to X-rays and Heavy-ion Beams-II(Bases of radiotherapy, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Radioprotective Effects of Beer on Radiation-Induced Acute Toxicity in Mice
• Dependence of Gut-crypt Sensitivity on the Time Interval between Two Fractions of Carbon Ion Radiation
• Tumor Growth Rate and RBE values of high LET Carbon Ions
• Dependence of Carbon-Ion RBE on Dose Size -Difference between Skin and Tumors
• RBE of Carbon Ions for Tumor Growth Delay
• ビールは放射線から体を守る?
• Mutation Induction in the rspL gene on an E. coli-B. subtilis shuttle vector by Space Flight on MIR
• Tumor Induction in Mice Locally Irradiated with Carbon Ions : A Retrospective Analysis
• Analysis of DNA damage checkpoint pathway in mammalian cells
• Cellular Responses after Heavy-ion Exposure
• Expression and localization of p53 and PARP in cultured mammalian cells exposed to accelerated Fe and Ar-ions
• Judgement on "Hit or Non-hit" by Time-Lapse Observations of CHO Cells Exposed to Accelerated Iron-ions.
• Analysis of Mutations in the Human HPRT Gene induced by High LET Heavy-ion Irradiation
• Time-Lapse Photographic Observation of CHO Cells Exposed to Accelerated Iron-Ions
• Mechanisms of Interphase-Death Induction for CHO Cells Exposed to Accelerated Heavy-Ions
• Skin Shrinkage Caused by Neon-20 and Carbon-12
• LET Dependence of Interphase Cell-Death Induction by Accelerated Heavy-Ions
• Dependence of Interphase Cell-Death Induction on LET Values of Accelerated Heavy-Ions
• Biological effects of heavy-ion irradiation on DNA double-strand breaks repair deficient mutant cell line
• Response of Crypt Cell Survivals of Mouse Intestine after Fractionated Doses of Accelerated Carbon-Ion with Spread-Out Bragg Peak.
• Increase of mitotic indices in a human salivary gland tumor xenograft after irradiation with particle beams.
• Chromosome Aberrations Induced by Neon lon Beams Produced by RIKEN Ring Cyclotron in human lymphocytes of blood.
• Position Determination by Laser Marks of Biological Samples Placed on a Plastic Track Detector and Inactivation of B. subtilis Spores by a Single Heavy Ion
• Exploration of 'Over Kill Effect' of High-LET Ar-and Fe-ions by Evaluating the Fraction of Non-hit Cell and Interphase Death
• Contribution of mutant p53 protein to hyper recombination leading to enhancement of spontaneous mutation.
• p53 protein contributed to repair of double strand break
• p53 and p21 protein induction in TK6 and NS human lymphoblastoid cells after X-ray and heavy ion irradiations.
• Effect of Pre-irradiation by Small Dose Heavy-ions in Human Cells
• Judgement on "Hit or Non-Hit" for the Cells Exposed to High-LET Heavy-Ions (Fe,Ar)
• Mutation induction after low-dose carbon-ion beam irradiation of frozen human cultured cells
• Mutation induction in frozen human cultured cells caused by low-dose carbon ion irradiation
• Detection of Adaptive Response at Chromosome Level
• DNA PKcs-independent error-prone DNA end-joining pathway and its role in radiation-induced mutagenesis
• Mutation Induction by Heavy-ion irradiation of gpt Δ Transgenic Mouse
• A fate of DNA double strand breaks in mammalian cells
• Introduction of a Normal Human Chromosome 8 Corrects Abnormal Phenotypes of Werner Syndrome Cells Immortalized by Expressing an hTERT Gene
• Delayed Induction of Telomere Instability in Normal Human Fibroblast Cells by Ionizing Radiation
• 226 Radiation-induced delayed chromosomal instability caused by large deletion(Genetic instability, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 223 Radiation-Induced Delayed Chromosomal Instability(Genetic instability, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 221 A Role of DNA Double Strand Break Repair in the Induction of Genetic Instability(Genetic instability, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 214 The complementation of abnormal phenotypes of Werner syndrome cells by expressing WRN gene(Physics, chemistry and DNA damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• S-2-3 Radiation-Induced Delayed Chromosome Aberrations(Radiation Induced Genetical Instability : What Is the Mechanism That a Cell Memorizes Being Irradiated?, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Instability of a Human Chromosome Exposed to Radiation in Unirradiated Mouse Cells
• The Role of DNA-PKcs Function on Induction of Genetic Instability by Radiation
• Radiation-induced genomic instability caused by large deletion (position)
• Thermosensitization by Inhibition of Gap Junctional Intercellular Communication
• Phenotypic Reversion of an X-Ray-Induced Transformant of Mouse m5S by Introduction of a Human Chromosome 11
• The Effect of DNA Repair Defects on the Induction of Delayed Chromosome Aberrations by Radiation
• Evidence for Induction of DNA Double Strand Breaks in the Bystander Response to Targeted Soft X-Rays in Repair Deficient CHO Cells
• Glycine Betaine, a Beer Component, Protects Radiation-induced Injury
• Biological Intercomparison Using Gut Crypt Survivals for Proton and Carbon-Ion Beams
• Increased Chromosome Instability and Accumulation of DNA Double-strand Breaks in Werner Syndrome Cells
• Biochemical Markers for in Situ Detection of DNA Double Strand Breaks in Cultured Mammalian Cells
• Exogenous Expression of Exonuclease Domain-deleted WRN Interferes with the Repair of Radiation-induced DNA Damages
• Differences in Effects of Oncogenes on Sensitivity to Anticancer Drugs
• Involvement of Reactive Oxygen Species (ROS) in the Induction of Genetic Instability by Radiation
• 225 Influence of Reactive Oxygen Species in the Induction of Genetic Instability by Radiation(Genetic instability, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 222 X-ray-induced genomic instability in Atm knock-out mouse cells(Genetic instability, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 220 Mechanism of radiation-induced delayed mutagenesis(Genetic instability, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 217 Localization of Phosphorylated H2AX and Phosphorylated p53 in Cells Inducing X-ray-induced Senescence-like Growth Arrest(Physics, chemistry and DNA damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 168 Mechanism of cell cycle-dependent cell death by heat shock(Radio-protection and sensitization, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 141 The role of site-specific phosphorylation on X-ray-induced p53 accumulation(Redox regulation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Early Growth of Experimental Lung Metastasis in Mouse
• 104 DNA Damage-Induced Phosphorylation of Histone H2AX and Alteration of Chromatin Structure(Repair of radiation damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 97 A Role of WRN Protein in the Recovery from DNA Replication Arrest(Repair of radiation damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Induction of Micronuclei in CHO Cells by Bleomycin but not by X-irradiation is Decreased by Treatment with HMG-CoA Reductase Inhibitors
• Involvement of reactive oxygen species (ROS) in the induction of genetic instability by radiation
• Relationship between dysfunction of WRN protein and radiosensitivity
• Role of WRN exonuclease in repair of DNA double strand breaks
• Effects of Beer Administration in Mice on Acute Toxicities Induced by X Rays and Carbon Ions
• Differences in pO_2 Peaks of a Murine Fibrosarcoma between Carbon-ion and X-ray Irradiation
• 267 Early Change of ^C-Thymidine Uptake after Carbon-beam Irradiation in Experimental Tumors(Bases of radiotherapy, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Phosphorylated ATM Foci as a Biochemical Marker for DNA Double Strand Breaks
• Mechanism of radiation-induced delayed mutagenesis
• Repair Kinetics of DNA-DSB Induced by X-rays or Carbon Ions under Oxic and Hypoxic Conditions
• Chromosomal Aberrations in Lymphocytes of Lung Cancer Patients Treated with Carbon Ions
• Ectopic Neurons in the Hippocampus may be a Cause of Learning Disability after Prenatal Exposure to X-rays in Rats
• De-coupling of blood flow and metabolism in the rat brain induced by glutamate
• Role of NMDA receptor upon [^C]acetate uptake into intact rat brain

もっと見る 閉じる

スポンサーリンク