Biological Intercomparison Using Gut Crypt Survivals for Proton and Carbon-Ion Beams
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概要
- 論文の詳細を見る
Charged particle therapy depends on biological information for the dose prescription. Relative biological effectiveness or RBE for this requirement could basically be provided by experimental data. As RBE values of protons and carbon ions depend on several factors such as cell/tissue type, biological endpoint, dose and fractionation schedule, a single RBE value could not deal with all different radiosensitivities. However, any biological model with accurate reproducibility is useful for comparing biological effectiveness between different facilities. We used mouse gut crypt survivals as endpoint, and compared the cell killing efficiency of proton beams at three Japanese facilities. Three Linac X-ray machines with 4 and 6 MeV were used as reference beams, and there was only a small variation (coefficient of variance < 2%) in biological effectiveness among them. The RBE values of protons relative to Linac X-rays ranged from 1.0 to 1.11 at the middle of a 6-cm SOBP (spread-out Bragg peak) and from 0.96 to 1.01 at the entrance plateau. The coefficient of variance for protons ranged between 4.0 and 5.1%. The biological comparison of carbon ions showed fairly good agreement in that the difference in biological effectiveness between NIRS/HIMAC and GSI/SIS was 1% for three positions within the 6-cm SOBP. The coefficient of variance was < 1.7, < 0.6 and < 1.6% for proximal, middle and distal SOBP, respectively. We conclude that the inter-institutional variation of biological effectiveness is smaller for carbon ions than protons, and that beam-spreading methods of carbon ions do not critically influence gut crypt survival.
- 日本放射線影響学会の論文
著者
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安藤 興一
放医研
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Sakae Takeji
Proton Medical Research Center University Of Tsukuba
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Sakae Takeji
放射線医学総合研究所重粒子医科学センター
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FURUSAWA Yoshiya
Heavy-ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Instit
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安藤 興一
学振科技特
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安藤 興一
Natl. Instit. Rad. Sci. Med.
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FURUSAWA Yoshiya
National Institute of Radiological Sciences
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FUTAMI Yasuyuki
Shizuoka Cancer Center
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Futami Yasuyuki
茨城県立医療大学 放射線技術科学科
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Futami Yasuyuki
The Institute Of Physics University Of Tsukuba
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Futami Yasuyuki
Dvisin Of Accelerator Physics And Engineering National Institite Of Radiological Sciences Chiba Japa
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Ando Koichi
Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences
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Ritter Sylvia
Dep. Of Biophysics Gesellschaft Fuer Schwerionenforschung (gsi)
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TERUNUMA Toshiyuki
Proton Medical Research Center (PMRC), Tsukuba Univ.
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UZAWA Akiko
Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Instit
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Ando K
Division Of Health Sciences Graduate School Of Medicine Osaka University
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Kagiya Go
Wakasawan Energy Research Center
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Kagiya Go
Wakasa-wan Energy Research Center
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Ando Koichi
Heavy-ion Radiobiology Res. Group National Inst. Of Radiological Sciences
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Fuji Hiroshi
Shizuoka Cancer Center
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Uzawa Akiko
Heavy-ion Radiobiology Research Group Research Center For Charged Particle Therapy National Institut
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Ando Soichiro
National Institute Of Radiological Sciences
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Ando Koichi
Department Of Technical Support And Development Natl. Inst. Radiol. Sci.
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Ando Koichi
Space And Particle Radiation Science Research Group National Institute Of Radiological Sciences
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Ritter Sylvia
Gesellschaft Fur Schwerionenforschung (gsi)
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HATA Masaharu
Proton Medical Research Center University of Tsukuba
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SCHOLZ Michael
Gesellschaft fur Schwerionenforschung (GSI)
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PESCHKE Peter
German Cancer Research Center DFKZ
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Ando Koichi
Division Of Health Sciences Graduate School Of Medicine Osaka University
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Uzawa Akiko
京都大学原子炉実験所附属粒子線腫瘍学研究センター
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Furusawa Y
Research Center For Charged Particle Therapy National Institute Of Radiological Sciences
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Furusawa Yoshiya
高エネルギー加速器研究機構物質構造科学研究所
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Sakae Takeji
Proton Medical Research Center (pmrc) University Of Tsukuba
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Terunuma Toshiyuki
Proton Medical Research Center University Of Tsukuba
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Furusawa Yoshiya
Heavy-ion Radiobiology Res. Group National Inst. Of Radiological Sciences
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Ando Koichi
Heavy-ion Radio. Res. Nirs
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Ando Koichi
International Space Radiation Laboratory National Institute Of Radiological Sciences
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Furusawa Yoshiya
Div. Of Accelerator Res. Natl. Inst. Of Radiol. Sci.
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Furusawa Yoshiya
Heavy-ion Radiobiol. Res. Gr. Res. Center Charged Particle Therapy Nirs.
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