Cell Cycle and LET Dependence for Radiation-induced Mutation : A Possible Mechanism for Reversed Dose-rate Effect

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概要

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• A previous study of the mutagenic action of ^<252>Cf radiation in mouse L5178Y cells showed that the mutation frequency was higher when the dose was chronic rather than acute, which was in sharp contrast to the effects reported for γ-rays (Nakamura and Sawada, 1988). A subsequent study using synchronized cells revealed that the cells at the G2/M stage were uniquely sensitive to mutation induction by ^<252>Cf radiation but not to γ-rays (Tauchi et al., 1993). A log phase cell population was first subjected to conditioning gamma or ^<252>Cf radiation doses at different dose-rates. The cell cycle distribution of these cells was then observed, and they were then exposed to ^<252>Cf radiation, and the mutation rate was determined. The G2/M fraction increased by 3- to 4-fold when the conditioning doses (2 Gy of gamma or 1 Gy of ^<252>Cf radiation) were delivered chronically over 10 h , but only slightly when the same doses were delivered over a 1 h period or less. Subsequent ^<252>Cf irradiation gave higher mutation frequencies in the cells pre-irradiated with γ-rays over a protracted period of time than in those exposed with the higher dose-rate γ-rays. These results suggest that the radiation-induced G2 block could be at least partly (but not totally) responsible for this reverse dose-rate effect (Tauchi et al. 1996). Possible factors which cause the hyper-sensitivity of G2/ M cells to mutation induction by neutrons will be discussed.

• 日本放射線影響学会の論文

著者

• Matsuura Shinya

  Particle Radiation Oncology Research Center Research Reactor Institute Kyoto University

• Komatsu Kenshi

  Department Of Genome Repair Dynamics Radiation Biology Center Kyoto University

• Matsuura Shinya

  Res. Inst. Rad. Biol. Med. Hiroshima Univ.

• Matsuura Shinya

  Department Of Radiation Biology Research Institute For Radiation Biology And Medicine (rirbm) Hirosh

• Matsuura Shinya

  Department Of Radiation Biology Research Institute For Radiation Biology And Medicine Hiroshima Univ

• Kamiya K

  Department Of Genome Repair Dynamics Radiation Biology Center Kyoto University

• TAUCHI Hiroshi

  Department of Biological Science, Faculty of Science, Ibaraki University

• 安藤 興一

  学振科技特

• Shinya Matsuura

  Res. Inst. Rad. Biol. Med. Hiroshima Univ.

• FURUSAWA Yoshiya

  National Institute of Radiological Sciences

• Futami Yasuyuki

  茨城県立医療大学 放射線技術科学科

• Futami Yasuyuki

  The Institute Of Physics University Of Tsukuba

• Futami Yasuyuki

  Dvisin Of Accelerator Physics And Engineering National Institite Of Radiological Sciences Chiba Japa

• Ando Koichi

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• 遠藤 暁

  Mechanical System Engineering Graduate School Of Engineering Hiroshima University

• Endo Satoru

  Department Of Biochemistry Cancer Institute Okayama University Medical School

• Nakamura Nori

  Dep. Of Genetics Radiation Effects Res. Foundation

• Nakamura Nori

  Genetics Radiation Effects Research Foundation

• Nakamura Nori

  Department Of Genetics Radiation Effects Research Foundation

• Tauchi Hiroshi

  Department Of Biological Science Faculty Of Science Ibaraki University

• FURUSAWA Yoshiya

  Space and Prticle Radiation Science Research Group, national Institute of Radiological Science (NIRS

• Komatsu Kenshi

  Dep. Of Genome Repair Dynamics Radiation Biology Center Kyoto Univ.

• Nakamura N

  Radiation Effects Res. Foundation Hiroshima Jpn

• KASAI Kiyomi

  Natl. Inst. Rad. Sci.

• SUGA SHINJI

  Research Institute for Radiation Biology and Medicine, Hiroshima University

• Suga Shinji

  Research Institute For Radiation Biology And Medicine Hiroshima University

• Eguchi-kasai Kiyomi

  Res. Center For Radiation Protection National Inst. Of Radiological Sciences

• Eguchi-kasai Kiyomi

  Radiation Effect Mechanisms Research Group Research Center For Radiation Protection National Institu

• SUZUKI MASAO

  Space and Particle Radiation Science Research Group, National Institute of Radiological Sciences

• ANDO KOICHI

  Space and Particle Radiation Science Research Group, National Institute of Radiological Sciences

• EGUCHI-KASAI Kiyomi

  Division of Radiation Hazards

• Tauchi Hiroshi

  Dep. Of Biological Sci. Fac. Of Sci. Ibaraki Univ.

• SAWADA Shozo

  Hiroshima Pref. Col. of Health and Welfare

• Ando Koichi

  Department Of Technical Support And Development Natl. Inst. Radiol. Sci.

• Ando Koichi

  Space And Particle Radiation Science Research Group National Institute Of Radiological Sciences

• Suzuki Masao

  Heavy-ion Radiobiology Res. Group National Inst. Radiological Sciences

• Endo Satoru

  Div. Environ. Biol. Res. Inst. Rad. Biol. And Med. Hiroshima University

• Masunaga Shin-ichiro

  Particle Radiation Oncology Research Center Research Reactor Institute Kyoto University

• Ando Koichi

  Division Of Health Sciences Graduate School Of Medicine Osaka University

• Nakamura Nori

  Departemnt Of Radiation Oncology Faculty Of Medicine University Of Tokyo

• Nakamura Nori

  Department Of Generics

• Shoji Syuneki

  Department Of Environment And Mutation Research Institute For Radiation Biology And Medicine

• Furusawa Yoshiya

  高エネルギー加速器研究機構物質構造科学研究所

• Sawada S

  Department Of Electronic Engineering College Of Science And Engineering Iwaki Meisei University

• Sawada S

  Iwaki Meisei Univ. Fukushima‐ken

• Sawada Shozo

  Department Of Applied Physics Chubu Institute Of Technology

• Sawada Shozo

  Department Of Physics College Of Science Tokyo Institute Of Technology

• Nakamura Nori

  Dept. Of Genetics Rerf

• Nakamura Nori

  Genet. Rerf

• Sawada S

  Research Institute For Radiation Biology And Medicine Hiroshima University

• Furusawa Yoshiya

  Space And Particle Radiation Science Res. Group Nirs.

• Tauchi Hiroshi

  Tokyo Institute Of Technology Research Laboratory For Nuclear Reactors

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