Positional cloning of the gene for Nijmegen breakage syndrome

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概要

• 論文の詳細を見る
• 日本放射線影響学会の論文

著者

• Matsuura Shinya

  Particle Radiation Oncology Research Center Research Reactor Institute Kyoto University

• Komatsu Kenshi

  Dept. Radiat. Biol. Res. Inst. Radiat. Biol. Med. Hiroshima Univ.

• Kamiya K

  Department Of Genome Repair Dynamics Radiation Biology Center Kyoto University

• SAKAMOTO Shuichi

  RBC, Kyoto Univ.

• TAUCHI Hiroshi

  Dept. Environ. Sci., Ibaraki Univ.

• NAKAMURA Asako

  Dept. Genome Repair Dynam., RBC, Kyoto Univ.

• MATSUURA Shinya

  Dept. Genome Repair Dynam., RBC, Kyoto Univ.

• Shinya Matsuura

  Res. Inst. Rad. Biol. Med. Hiroshima Univ.

• Komatsu Kenshi

  Dep. Of Genome Repair Dynamics Radiation Biology Center Kyoto Univ.

• Isomura Minoru

  Lab. Mol. Med. Univ. Of Tokyo

• Oshimura Mitsuo

  Dept. Of Mol. Cell Genet. Tottori Univ.

• Oshimura Mitsuo

  Dept. Biomedical Science Grad. Sch. Medical Science Tottori Univ.

• KONDO Noriko

  Dept. of Rad. Biol., RIRBM, Hiroshima Univ.

• SAKAMOTO Shuichi

  Dept. of Rad. Biol., RIRBM, Hiroshima Univ.

• NAKAMURA Yusuke

  Lab. Mol. Med., Univ. of Tokyo

• Tauchi Hiroshi

  Dept. Environ. Sci. Ibaraki Univ.

• Sakamoto Shuichi

  Rbc Kyoto Univ.

• Nakamura Asako

  Dept. Genome Repair Dynam. Rbc Kyoto Univ.

• Kondo Noriko

  Dept. Of Rad. Biol. Rirbm Hiroshima Univ.

• Nakamura Yusuke

  Lab. Mol. Med. Univ. Of Tokyo

• Komatsu Kenshi

  Dept. Radiat. Biol. Res. Inst. For Radiat. Biol. Med. Hiroshimauniv.

• Komatsu Kenshi

  Dept. Genome Repair Dynamics Rad. Biol. Center Kyoto Univ.

• Tauchi Hiroshi

  Tokyo Institute Of Technology Research Laboratory For Nuclear Reactors

関連論文

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• Two Major Factors Involved in the Reverse Dose-rate Effect for Somatic Mutation Induction are the Cell Cycle Position and LET Value
• 242 Analysis of apoptosis induction in Nbs1 deficient cells(Apoptosis related, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 206 Functional Domain Analysis of NBS1 Gene in Homologous Recombinational Repair(Physics, chemistry and DNA damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 182 Effect of gravity stress on homologous recombination(Environmental effects of radiation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 98 Localization of Rad51 protein in cells from patients with Fanconi Anemia D1 group(Repair of radiation damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 19 Analysis of Mutation Induction By Low Dose Rate Tritium Radiation Using Hyper Sensitive Detection System(Low dose and low dose-rate effects, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
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• Mutation screening for a novel cancer-predisposition syndrome of total PCS
• p53-Binding Protein 1 (53BP1) is Involved in the Repair of DNA Double-Strand Breaks
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• Histone H2AX regulates the formation of NBS1 foci on DNA damage sites
• Dissociation of ATM/NBS1 functions in telomere maintenance
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• The relationship between the minimally deleted region of the mouse chromosome 2 and the murine acutemyeloid leukemia development.
• Bystander mutagenic effect of alpha particle in human-hamster hybrid cells
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• Establishement of mouse Nbs1-deficient cell lines by gene targeting
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• Estimation of Dose Absorbed Fraction for ^I-bera rays in Rat Thyroid
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• Association of DNA repair protein NBS1 with telomere maintenance
• The function of NBS1 and histone H2AX in the early process of DNA repair.
• Reversed dose-rate effect of high LET radiation in mutation induction
• Chromosomal instability syndrome of total premature chromatid separation with mosaic variegated aneuploidy is defective in mitotic spindle checkpoint
• Screening of protein interacting with FANCG by Yeast two-hybrid system
• A Comparison of Biological Responses of Human Tumor Cells After Irradiation with Heavy Ions and Neutrons
• Four novel mutations of the Fanconi anemia group A gene (FAA) in Japanese patients
• Accumulation of Cells at G_2/M Stage by Low Dose-Rate Irradiation Renders the Cell Population More Susceptible to the Subsequent Induction of 6-Thioguanine-Resistant Mutations by ^Cf Fission Neutrons.
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• Functionally important domain analysis of the Nijimegen breakage syndrome gene. NBS1
• Development of a Radio-sensitive Mutation System for the Study of Dose Rate Effects of Space High LET Radiation
• NBS1, the Nijmegen breakage syndrome protein, regulates the localization of DNA repair complex hRAD50/hMRE11/NBS1
• Accelerated telomere shortening by disruption of DNA repair protein NBS1
• Construction of Nbs1 knockout cell line using chicken DT40
• 誘発突然変異と損傷乗り越えDNA合成 : REV1の構造と生化学的機能
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• P054 Effect of REV1 on the survival of human cells after various DNA damages(Poster Session)
• W2-2 Effect of REV1 on the survival of human cells after various DNA damages(Workshop(2) : Translesion DNA Synthesis and Mutagenesis)
• 一般演題 2 広島大学「原爆・被ばく関連資料データベース」 の概要と公開の意義
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• マウス肝癌におけるIGFBP-7遺伝子の発現低下
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• Responses of total and quiescent cell populations in solid tumors to carbon ion beam irradiation (290 MeV/u) in vivo
• Zuckerラットを用いた味噌による脂肪肝の減少効果
• Nijmegen Breakage Syndrome (NBS) gene, NBS1, is involved in telomeric length maintenance.
• Induction of dominant lethality and developmental anomalies in offspring of male mice inadiated to varying doses of ^Cf fission neutrons
• Loss of p53 -dependent signal transdution in γ -ray irradiated scid mouse fibroblasts
• Positional cloning of the gene for Nijmegen breakage syndrome
• Genetic Mapping of Nijmegen Breakage Syndrome using Functional Complementation Assays and Homozygosity Mapping
• Haplotype Analysis of Nijmegen Breakage Syndrome and Construction of Physical Map of Candidate Region.
• Complementation Assay between Radiation-Sensitive irs2 Mutant and Ataxia-Telangiectasia Cell
• The Genetic Homogeneity of Nijmegen Breakage Syndrome V1 and V2.
• Mapping of the underlying gene for rare genetic complementation group Fanconi anemia
• Effect of gravity stress on fidelity of DNA double-strand break repair
• Neutron Generator (HIRRAC) and Dosimetry Study
• Development of a low energy proton irradiation system using HIRRAC
• A biophysical estimate of radioactive iodine (^I) exposure in the whole body and in the thyroid of newborn, puberty and adult Fischer 344 rats.
• NBS1 Regulates Apoptosis Induced by γ-Irradiation in Lymphoblastoid
• Mutation screening of the NBS1 gene in sporadic malignant lymphoma
• LET, cell cycle dependence for mutation induction and spectrum in HPRT locus
• Cell Cycle and LET Dependence for Radiation-induced Mutation : A Possible Mechanism for Reversed Dose-rate Effect
• Radiation-induced internal developmental abnormalities in scid mice
• Radiation-induced teratogenicity and embryo lethality in the scid mice.
• Mutation Analysis of the Fanconi Anemia Gene FAA in Japanese patients
• Mutation Analysis of the Fanconi Anemia Genes in Japanese Patients
• Kinetics of Mammary Clonogenic Cells and Rat Mammary Cancer Induction by X-rays or Fission Neutrons
• Age-dependent Exposure to Radioactive Iodine (^I) in the Thyroid and Total Body of Newborn, Pubertal and Adult Fischer 344 Rats
• Function of NBS1 in Activation of ATM kinase in Response to IR.
• O-15. Chromosome instability and cancer predisposition in the PCS (premature chromatid separation) syndrome(Abstracts of the oral and poster presentations,Abstracts of the 55th Annual Meeting of the Society of Chromosome Research)
• O-11. The optimal conditions for cytological diagnosis of total premature chromatid separation (PCS), a novel cancer-prone genetic trait associated with mitotic checkpoint defect(Abstracts of the oral and poster presentations)(The 53rd Annual Meeting of t
• Heat sensitivity of DNA-dependent protein kinase activity
• The genetic complementation assay of Nijmegen breakage syndrome witit ataxia telangiectasia on the basis of radiation sensitivity to cell killing.
• Nijmegen breakage syndrome : Sequence analysis of an 800-kb genomic region on chromosome 8q21.
• The scid factor on human chromosome 8 restores both V(D)J recombination and double-strand break repair
• The relationship between NBS1 and cell death induced by γ-ray irradiation in lymphoblastoid
• Cell cycle and LET dependence for 6-thioguanine-resistant mutation induced by heavy ion beam in mouse L5178Y cells
• Recovery of heat inactivated DNA-PK activity and HSC73
• Recovery of heat inactivated DNA-PK activity and repair of DNA double strand break
• Sensitivity of Heavy-Ion Beam in Scid Mouse Lung Fibroblast Cells.
• Thermosensitivity and DNA-PK activity of scid cells and hybrid scid cells containing human chromosome 8
• Genetic heterogeneity of ataxia-telangiectasia-like hamster mutant irs2 with Nijmegen breakage syndrome
• Genetic heterogeneity of ataxia-telangiectasia-like hamster mutant irs2 with Nijmegen breakage syndrome.
• Thermosensitivity and Thermotolerance of Scid Mouse Lung Fibroblast Cells.
• Effect of Low Dose Irradiation on the ConA Response of Mouse Splenic Lymphocytes
• Radiation-induced HPRT mutation of a radiation sensitive hamster cell line irs1SF
• DNA-dependent protein kinase restores mouse scid mutation
• Inhibition of radiation-induced oncogenic transformation in C3H10T1/2 cells by green tea component, (-)-epigallocatechin gal late.

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