Loss of p53 -dependent signal transdution in γ -ray irradiated scid mouse fibroblasts

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概要

• 論文の詳細を見る
• 日本放射線影響学会の論文

著者

• Komatsu Kenshi

  Dept. Radiat. Biol. Res. Inst. Radiat. Biol. Med. Hiroshima Univ.

• TAUCHI Hiroshi

  Dept. Environ. Sci., Ibaraki Univ.

• OHNISHI Takeo

  Dept. Biol. Nara Med. Univ.

• Matsumoto Hideki

  Dept. Exp. Radiol. Health Phys. Fukui Med. Univ.

• Matsumoto Hideki

  Division Of Oncology Biomedical Imaging Research Center University Of Fukui

• Ono Koji

  Particle Radiation Oncology Research Center Kyoto University

• OHNISHI Ken

  Dept. Biol. Nara Med. Univ.

• Nakano T

  Centrifuge Project Team Nasda

• Komatsu Kenshi

  Dept. Radiation Biol. Hiroshima Univ. Reseaich Inst. Radiation Biol. Med.

• Tauchi Hiroshi

  Dept. Radiation Biol. Hiroshima Univ. Reseaich Inst. Radiation Biol. Med.

• Xinjiang Wang

  Dept. Of Biol. Nara Med. Univ.

• TAKAHASHI Akihisa

  1Dept. Biol.

• NAKANO Tatsuo

  Botani. Inst. , PL Gakuen Women's Jr. Col.

• Tauchi Hiroshi

  Dept. Environ. Sci. Ibaraki Univ.

• Wan Xinjiang

  Dept. Of Biol. Nara Med. Univ.

• Xinjiang Wang

  Dept. Biol.

• Takehana Naohiro

  Centrifuge Project Team Nasda

• Majima Hideyuki

  Departments Of Experimental Radiology And Health Physics

• Tanaka Naritaka

  Department Of General Surgical Science (surgery I) Gunma University Graduate School Of Medicine

• Komatsu Kenshi

  Dept. Radiat. Biol. Res. Inst. For Radiat. Biol. Med. Hiroshimauniv.

• Matsumoto Hideki

  Nara Med. Univ.

• Matsumoto Hideki

  Dept. Exp. Radiol. Health Phys. Fac. Med. Sci. Univ. Fukui

• Komatsu Kenshi

  Dept. Genome Repair Dynamics Rad. Biol. Center Kyoto Univ.

• OHNISHI Takeo

  Dept. Biol. , Nara Med. Univ.

関連論文

• The Foci of DNA Double Strand Break-recognition Proteins Localize with γH2AX after Heat Treatment
• DNA Damage Recognition Proteins Localize along Heavy Ion Induced Tracks in the Cell Nucleus
• LOH Analyses for Biological Effects of Space Radiation : Human Cell Culture in "Kibo" of International Space Station
• 242 Analysis of apoptosis induction in Nbs1 deficient cells(Apoptosis related, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 206 Functional Domain Analysis of NBS1 Gene in Homologous Recombinational Repair(Physics, chemistry and DNA damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 182 Effect of gravity stress on homologous recombination(Environmental effects of radiation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 98 Localization of Rad51 protein in cells from patients with Fanconi Anemia D1 group(Repair of radiation damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 19 Analysis of Mutation Induction By Low Dose Rate Tritium Radiation Using Hyper Sensitive Detection System(Low dose and low dose-rate effects, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• S-3-1 Mechanisms of DNA double-strand break repair(Biological Effects of Low Dose and Low Dose-rate Irradiations, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Analysis of the cell death after irradiation in the cells with defective DNA repair
• p53-Binding Protein 1 (53BP1) is Involved in the Repair of DNA Double-Strand Breaks
• Analysis of the function of NBS1 in DNA double-strand break repair
• Histone H2AX regulates the formation of NBS1 foci on DNA damage sites
• Dissociation of ATM/NBS1 functions in telomere maintenance
• NBS1 is involved in recognition of DNA damage and initiation of homologous recombination.
• Bystander mutagenic effect of alpha particle in human-hamster hybrid cells
• Somatic Mutation Caused by Low Dose Rate Tritium Radiation : Studies Using A Hyper-sensitive DetectionSystem
• Complementation studies of immortalized cell lines from infants with total PCS
• Establishement of mouse Nbs1-deficient cell lines by gene targeting
• Association of cells from Fanconi anemia patients with radiation sensitivity
• Effects of p53 Status on Radiosensitivity and the Size of Hypoxic Fraction of Intratumor Total and QuiescentCell Populations
• High LET Heavy Ion Radiation Induces p53-Independent Apoptosis
• High LET radiation enhances apoptosis in mutated p53 cancer cells through Caspase-9 activation
• The Biology of Heat-induced DNA Double-Strand Breaks
• Time Course and Spacial Distribution of UV Effects on Human Skin in Organ Culture
• Development of thermotolerance requires interaction between polymerase-β and heat shock proteins
• Association of DNA repair protein NBS1 with telomere maintenance
• The function of NBS1 and histone H2AX in the early process of DNA repair.
• Reversed dose-rate effect of high LET radiation in mutation induction
• Chromosomal instability syndrome of total premature chromatid separation with mosaic variegated aneuploidy is defective in mitotic spindle checkpoint
• Screening of protein interacting with FANCG by Yeast two-hybrid system
• The First Life Science Experiments in ISS : Reports of "Rad Gene"-Space Radiation Effects on Human Cultured Cells-
• Recent Advances in the Biology of Heavy-Ion Cancer Therapy
• ATM is the Predominant Kinase Involved in the Phosphorylation of Histone H2AX after Heating
• Usefulness of Hexamethylenetetramine as an Adjuvant to Radiation and Cisplatin in the Treatment of Solid Tumors : its Independency of p53 Status
• 9 Modulation of nitric oxide-mediated bystander effects by chronic irradiation with gamma-rays(Low dose and low dose-rate effects, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Modulation of NO-Mediated Bystander Effect by Pre-Gamma-Ray Irradiation with Low-Dose Rate
• The effect of artificial gravity on the morphogenesis of UV-irradiated Dict ostelium discoldeum cells.
• Increase of wtp53 pool size in specific organs of mice by low doses of X-ray.
• Preferential Inhibition of Nucleosome Assembly by (6-4) Photo products,
• Functionally important domain analysis of the Nijimegen breakage syndrome gene. NBS1
• Development of a Radio-sensitive Mutation System for the Study of Dose Rate Effects of Space High LET Radiation
• 84 Effects of Mild Temperature Hyperthermia and p53 Status of Tumor Cells on the Size of Hypoxic Cell Fractions in Solid Tumors(Radiation sensitivities in cells & tissues, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• NBS1, the Nijmegen breakage syndrome protein, regulates the localization of DNA repair complex hRAD50/hMRE11/NBS1
• Accelerated telomere shortening by disruption of DNA repair protein NBS1
• Construction of Nbs1 knockout cell line using chicken DT40
• Nijmegen Breakage Syndrome (NBS) gene, NBS1, is involved in telomeric length maintenance.
• コンピュータによるイメージ加工と温熱誘導γH2AXフォーカスの解析
• The Effects of Irradiation of Low Dose and Low Dose Rate on p53-centered Signal Transduction in Human Glioblastoma Cells (A-172)
• A role of poly (ADP-Ribose) lation in Radiation-induced Waf1 Induction in Human Glioblastoma Cells.
• Effects of an Inhibitor of Poly(ADP-Ribose) Polymerase, 3-Aminobenzamide, on γ-Induced WAF1 Gene Expression in Human Glioblastoma Cells.
• p53-Dependence of Heat- or γ-Ray-Induced Signal Transduction for WAF1 Expression of Human Glioblastoma Cells (A-172/wtp53) Transfected with mp53 Gene.
• Bifunctional Effects of a Protein Kinase Inhibitor (H-7) on Heat-Induced p53-Dependent WAF1 Accumulation
• WAF1 induction by α-rays in human glioblastoma cell lines.
• Loss of p53 -dependent signal transdution in γ -ray irradiated scid mouse fibroblasts
• Contribution of PKC to accumulation of hsp72 after UV or heat treatment
• Induction of p53 and WAFJ in Heat-treated Human Glioblastoma cells
• Effect of p53-type on γ-ray or UV induced chromosomal aberration
• Positional cloning of the gene for Nijmegen breakage syndrome
• Genetic Mapping of Nijmegen Breakage Syndrome using Functional Complementation Assays and Homozygosity Mapping
• Haplotype Analysis of Nijmegen Breakage Syndrome and Construction of Physical Map of Candidate Region.
• Complementation Assay between Radiation-Sensitive irs2 Mutant and Ataxia-Telangiectasia Cell
• The Genetic Homogeneity of Nijmegen Breakage Syndrome V1 and V2.
• Mapping of the underlying gene for rare genetic complementation group Fanconi anemia
• Effect of gravity stress on fidelity of DNA double-strand break repair
• NBS1 Regulates Apoptosis Induced by γ-Irradiation in Lymphoblastoid
• Mutation screening of the NBS1 gene in sporadic malignant lymphoma
• LET, cell cycle dependence for mutation induction and spectrum in HPRT locus
• Radiation-induced internal developmental abnormalities in scid mice
• Effect of Microgravity on the Cell Recovery of Escherichia coli Pre-Irradiated by Carbon Ion Beams
• Restraint Plus Water-immersion Stress (RWIS)-induced Stomach Ulcers in Mice are Depressed by a Conditioning Heat Treatment
• Mutation Analysis of the Fanconi Anemia Gene FAA in Japanese patients
• Mutation Analysis of the Fanconi Anemia Genes in Japanese Patients
• Expression of p53-Regulated Genes in Cultured Mammalian Cells After Exposure to A Space Environment
• Radiosensitivity and Radioadaptive Response Induced by Pre-irradiation with a Low Dose in Rolling MouseNagoya
• Function of NBS1 in Activation of ATM kinase in Response to IR.
• Radiation-induced Apoptotic Cell Death in Human Gastric Epithelial Tumor Cells
• Heat sensitivity of DNA-dependent protein kinase activity
• The genetic complementation assay of Nijmegen breakage syndrome witit ataxia telangiectasia on the basis of radiation sensitivity to cell killing.
• Molecular cloning of the genes expressed by VEGF-stimulation involved in the suppression of apoptosis induced by ionizing radiation
• Vanguards of Paradigm Shift in Radiation Biology: Radiation-Induced Adaptive and Bystander Responses
• Radiation-Induced Adaptive Responses and Bystander Effects
• 248 Enhancement of radio-/heat-sensitivity by an inhibitor, LY294002, for PI3K(Apoptosis related, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Suppressive Effects of Vascular Endothelial Growth Factor (VEGF) on Apoptosis in Hematopoietic Stem Cells Induced by Exposure to γ-Rays
• Induction of 6-thioguanine-resistant mutations by ^Cf fission neutrons in the cells pre-irradiated at low dose-rate.
• Nijmegen breakage syndrome : Sequence analysis of an 800-kb genomic region on chromosome 8q21.
• p53-Dependent Heat Sensitivity in Human Squamous Cell Carcinoma of the Tongue Transfected with mp53 Gene
• The scid factor on human chromosome 8 restores both V(D)J recombination and double-strand break repair
• The relationship between NBS1 and cell death induced by γ-ray irradiation in lymphoblastoid
• Cell cycle and LET dependence for 6-thioguanine-resistant mutation induced by heavy ion beam in mouse L5178Y cells
• Contribution of Radiation-Induced, Nitric Oxide-mediated Bystander Effect to Radiation-Induced Adaptive Response
• Relationship between p53 status and amount of hsp72 induction in human cancer cells.
• Recovery of heat inactivated DNA-PK activity and HSC73
• Recovery of heat inactivated DNA-PK activity and repair of DNA double strand break
• Sensitivity of Heavy-Ion Beam in Scid Mouse Lung Fibroblast Cells.
• Thermosensitivity and DNA-PK activity of scid cells and hybrid scid cells containing human chromosome 8
• Genetic heterogeneity of ataxia-telangiectasia-like hamster mutant irs2 with Nijmegen breakage syndrome
• Genetic heterogeneity of ataxia-telangiectasia-like hamster mutant irs2 with Nijmegen breakage syndrome.
• Thermosensitivity and Thermotolerance of Scid Mouse Lung Fibroblast Cells.
• Effect of Low Dose Irradiation on the ConA Response of Mouse Splenic Lymphocytes

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