Tauchi Hiroshi | Tokyo Institute Of Technology Research Laboratory For Nuclear Reactors
スポンサーリンク
概要
関連著者
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Kamiya K
Department Of Genome Repair Dynamics Radiation Biology Center Kyoto University
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Matsuura Shinya
Particle Radiation Oncology Research Center Research Reactor Institute Kyoto University
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Shinya Matsuura
Res. Inst. Rad. Biol. Med. Hiroshima Univ.
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Komatsu Kenshi
Dep. Of Genome Repair Dynamics Radiation Biology Center Kyoto Univ.
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Tauchi Hiroshi
Department Of Biological Science Faculty Of Science Ibaraki University
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MATSUURA Shinya
Dept. Genome Repair Dynam., RBC, Kyoto Univ.
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Tauchi Hiroshi
Dep. Env. Sci. Fac. Sci. Ibaraki Univ.
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TAUCHI Hiroshi
Dept. Environ. Sci., Ibaraki Univ.
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Komatsu Kenshi
Dept. Radiat. Biol. Res. Inst. Radiat. Biol. Med. Hiroshima Univ.
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Matsuura Shinya
Res. Inst. Rad. Biol. Med. Hiroshima Univ.
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Matsuura Shinya
Department Of Radiation Biology Research Institute For Radiation Biology And Medicine Hiroshima Univ
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神谷 研二
広島大学原爆放射線医科学研究所 分子発がん
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Matsuura Shinya
京都大学放射線生物研究センター
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Komatsu Kenshi
Research Institute For Radiation Biology And Medicine Hiroshima University
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NAKAMURA Asako
Dept. Genome Repair Dynam., RBC, Kyoto Univ.
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Kobayashi Jyunya
Department Of Genome Repair Dynamics Radiation Biology Center Kyoto University
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Komatsu K
Department Of Genome Repair Dynamics Radiation Biology Center Kyoto University
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遠藤 暁
Mechanical System Engineering Graduate School Of Engineering Hiroshima University
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Endo Satoru
Department Of Biochemistry Cancer Institute Okayama University Medical School
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MORISHIMA Kenichi
Dept. Rad. Biol., RIRBM, Hiroshima Univ.
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Kobayashi Junya
Department Of Genome Repair Dynamics Radiation Biology Center Kyoto University
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SAKAMOTO Shuichi
RBC, Kyoto Univ.
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ICHIMASA Michiko
Dept. Environ. Sci., Ibaraki Univ.
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KOBAYASHI Junya
Dept. Rad. Biol., RIRBM, Hiroshima Univ.
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Komatsu Kenshi
Department Of Radiation Biology Research Institute For Radiation Biology And Medicine Hiroshima Univ
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豊田 新
岡山理大
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ICHIMASA Yusuke
Dept. Environ. Sci., Ibaraki Univ.
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豊田 新
岡山理科大学 理学部応用物理学科
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Takeoka Seiji
Dept. Radiat. Genet. Kyoto Univ.
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TAKEDA Shunichi
Dept. Rad. Genet. Kyoto Univ.
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TAUCHI Hiroshi
Department of Biological Science, Faculty of Science, Ibaraki University
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MORISHIMA Ken-ichi
Dept. Genome Repair Dynam., Rad. Biol. Center, Kyoto Univ.
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Komatsu Kenshi
Department Of Genome Repair Dynamics Radiation Biology Center Kyoto University
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TAUCHI Hiroshi
Fac. Sci., Ibaraki Univ.
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SHIRAISHI Takahiro
Dept. Rad. Biol., RIRBM., Hiroshima Univ.
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SUGA SHINJI
Research Institute for Radiation Biology and Medicine, Hiroshima University
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KOMATSU Kenshi
RBC, Kyoto Univ.
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SHINOHARA Miki
Dept. Rad. Biol., RIRBM, Hiroshima Univ.
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IDE Toshinori
Dept. Cell. Mol. Biol., Hiroshima Univ.
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ITO Emi
Dept. Rad. Biol., RIRBM, Hiroshima Univ.
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安藤 興一
学振科技特
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EGUCHI-KASAI Kiyomi
NIRS
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Futami Yasuyuki
茨城県立医療大学 放射線技術科学科
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Futami Yasuyuki
Dvisin Of Accelerator Physics And Engineering National Institite Of Radiological Sciences Chiba Japa
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Komatsu K
Hiroshima Univ. Hiroshima Jpn
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Matsuura Shinya
Department Of Radiation Biology Research Institute For Radiation Biology And Medicine (rirbm) Hirosh
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TAUCHI Hiroshi
Sch. of Sci., Ibaraki Univ.
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TANIMOTO Keiji
Oral and Maxillofacial Radiol., Grad. Sch. Biomed. Sci., Hiroshima Univ.
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FURUSAWA Yoshiya
National Institute of Radiological Sciences
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C. Weemaes
Nijmegen Univ. Hosp.
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Kobayashi Junya
京都大学放射線生物研究センター ゲノム動態研究所
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MURANAKA Chizuko
Dept. Environ. Sci., Ibaraki Univ.
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MATSUURA Shinya
RIRBM, Hiroshima Univ.
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IIJIMA Kenta
Dept. Environ. Sci., Ibaraki Univ.
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MATSUMOTO Eigo
Dept. Environ. Sci., Ibaraki Univ.
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IKEUCHI Tatsuro
Div. Genet., MRI, Tokyo Med. Dent, Univ.
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KOBAYASHI Jyunya
Dept. Oral. Radiol., Hiroshima Univ. Dent. Sch.
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高田 純
Department Of Physics School Of Medicine Sapporo Medical University
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Matsuura Shinya
Rirbm Hiroshima Univ.
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Futami Yasuyuki
The Institute Of Physics University Of Tsukuba
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Ando Koichi
Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences
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Watanabe Hiromitsu
Research Institute for Radiation Biology and Medicine, Hiroshima University
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Watanabe Hiromitsu
広島大学原爆放射能医学研究所
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Watanabe H
Res. Inst. Rad. Biol. &med. Hiroshima Univ.
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Nakamura Nori
Genetics Radiation Effects Research Foundation
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HANADA Ryoji
Saitama Children's Medical Center
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OHASHI Hirofumi
Saitama Children's Medical Center
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MASUNO Mitsuo
Kanagawa Children's Medical Center
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IMAIZUMI Kiyoshi
Kanagawa Children's Medical Center
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Nakamura N
Radiation Effects Res. Foundation Hiroshima Jpn
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J. Thacker
Mrc Rad. And Genome Stability Unit Uk
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Komatsu Kenshi
Radiation Biology Center Kyoto Univ.
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KOBAYASHI Junya
RIRBM, Hiroshima Univ.
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MOCHIZUKI Daisuke
Dept. Environ. Sci., Ibaraki Univ.
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ANTOCCIA Antonio
Dept. Rad. Biol., RIRBM, Hiroshima Univ.
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KOMATSU Kenshi
Rad. Biol Center Kyoto Univ.
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IMAMURA Kouji
MBL
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KOBAYASHI Junya
Oral and Maxillofacial Radiol., Grad. Sch. Biomed. Sci., Hiroshima Univ.
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TAUCHI Hiroshi
Environ. Sci., Sch. Sci., Ibaraki Univ.
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KAJII Tadashi
Hachioji
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FUTAMI Yasuyuki
Shizuoka Cancer Center
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Watanabe H
Department Of Experimental Oncology Research Institute For Radiation Biology And Medicine Hiroshima
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Nakamura Nori
Department Of Genetics Radiation Effects Research Foundation
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Shoji Shuneki
Dept. Environ. Mutat. Res. Inst. Forradiat. Biol. Med. Hiroshima Univ.
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Shoji Shuneki
広島大学原爆放射能医学研究所
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Takata Minoru
Dep. Of Late Effects Studies Radiation Biology Center Kyoto Univ.
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Takeda Shunichi
Dept. Radiat. Gen. Kyoto Univ.
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Takami Hideki
Dept. Of Rad. Biol. Res. Inst. Rad. Biol. &med. Hiroshima Univ.
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NAKAMURA Asako
Department of Radiation Biology, Research Institute for Radiation Biology and Medicine, Hiroshima Un
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HONDA Koujiro
Kanagawa Children's Medical Center
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KASAI Kiyomi
Natl. Inst. Rad. Sci.
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遠藤 暁
広島大学原爆放射能医学研究所
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Tanimoto Keiji
広島大学 歯 歯科放射線
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Furusawa Yoshiya
Research Center For Charged Particle Therapy National Institute Of Radiological Sciences
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WAKU Hiroyuki
Department of Biological Science, Faculty of Science, Ibaraki University
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MATSUMOTO Eigo
Department of Biological Science, Faculty of Science, Ibaraki University
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YARA Sayaka
Department of Biological Science, Faculty of Science, Ibaraki University
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OKUMURA Shino
Department of Biological Science, Faculty of Science, Ibaraki University
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IWATA Yoshiyuki
Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
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EGUCHI KASAI
Research Center for Radiation Protection, National Institute of Radiological Sciences
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TACHIBANA Akira
Department of Biological Science, Faculty of Science, Ibaraki University
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OGATA Hiromi
Dept. Environ. Sci., Ibaraki Univ.
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SAKAMOTO Syuichi
Dept. Genome Repair Dynam., RBC, Kyoto Univ.
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TAUCHI Hiroshi
Fac., Sci., Ibaraki Univ.
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GOBARA Yohji
Dept. Environ. Sci., Ibaraki Univ.
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YOKOZAWA Daisuke
Dept. Environ. Sci., Ibaraki Univ.
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GENT Dik
Erasmus Univ.
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KOMATA Hiroyasu
Dept. Environ. Sci. Ibaraki Univ.
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KAJII Tadashi
Div. Genet., MRI, Tokyo Med. Dent, Univ.
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IWABUCHI Kuniyoshi
Dept. Biochem., Kanazawa Medical Univ.
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KURIHARA Takayuki
Med. Res. Inst., Kanazawa Medical Univ.
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SHIBATA Masao
MBL
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CAO Yongheng
Dept. Biochem., Kanazawa Medical Univ.
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HAMADA Tomio
Dept. Biochem., Kanazawa Medical Univ.
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AOKI Hidetoshi
Dept. Geriatric Res., Natl. Inst. Longevity Sci.
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MOTOYAMA Noboru
Dept. Geriatric Res., Natl. Inst. Longevity Sci.
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DATE Takayasu
Dept. Biochem., Kanazawa Medical Univ.
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Gent an
Erasmus University Rotterdam
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SAKAMOTO Shuchi
Dept. Genome Repair Dynam., Rad. Biol. Center, Kyoto Univ.
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KOMATSU Kenshi
Genome Repair Dynamics, Radiat. Biol. Cent., Kyoto University
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SAKAMOTO Shuichi
Genome Repair Dynamics, Radiat. Biol. Cent., Kyoto University
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NAKAMURA Asako
Genome Repair Dynamics, Radiat. Biol. Cent., Kyoto University
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MORISIMA Kenichi
Genome Repair Dynamics, Radiat. Biol. Cent., Kyoto University
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ICHIKAWA Koji
Dept. Cell Biol., Cancer Inst.
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KIMURA Akiro
Dept. Hemat. Oncol., RIRBM, Hiroshima Univ.
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WATANABE Hiromitsu
Dept. Environ. Mut., RIRBM, Hiroshima Univ.
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ENDO SATORU
Research Institute for Radiation Biology and Medicine, Hiroshima University
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NITTA YUMIKO
Research Institute for Radiation Biology and Medicine, Hiroshima University
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OHTAKI MEGU
Research Institute for Radiation Biology and Medicine, Hiroshima University
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TAKADA JUN
Research Institute for Radiation Biology and Medicine, Hiroshima University
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STEPANENKO VARELI
Medical Radiological Research Center, Russian Academy of Medical Sciences
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TAUCHI HIROSHI
Research Institute for Radiation Biology and Medicine, Hiroshima University
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MATSUURA SYNYA
Research Institute for Radiation Biology and Medicine, Hiroshima University
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IASKOVA E.
Medical Radiological Research Center, Russian Academy of Medical Sciences
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HOSHI MASAHARU
Research Institute for Radiation Biology and Medicine, Hiroshima University
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SHOJI Shuneki
Div. of Environ. Biol. , Res. Inst. Rad. Biol. Med. , Hiroshima University.
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WATANABE Hiromitsu
Div. of Environ. Biol. , Res. Inst. Rad. Biol. Med. , Hiroshima University.
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ITO Akihiro
Div. of Environ. Biol. , Res. Inst. Rad. Biol. Med. , Hiroshima University.
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HOSHI Masaharu
International Radiation Information Center, Research Institute for Radiation Biology and Medicine, H
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Suzuki Keiji
Graduate School Of Biomedical Sciences Nagasaki University
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遠藤 暁
広島大学原爆放射線医科学研究所・線量測定 評価
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遠藤 暁
広島大学原爆放射能医学研究所放射線基礎研究分野
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HOSHI M.
広島大学原爆放射能医学研究所放射線基礎研究分野
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TAUCHI H.
広島大学原爆放射能医学研究所放射線基礎研究分野
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TAKEOKA S.
広島大学原爆放射能医学研究所放射線基礎研究分野
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KITAGAWA K.
広島大学原爆放射能医学研究所放射線基礎研究分野
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SUGA S.
広島大学原爆放射能医学研究所放射線基礎研究分野
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MAEDA N.
広島大学原爆放射能医学研究所放射線基礎研究分野
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KOMATSU K.
広島大学原爆放射能医学研究所放射線基礎研究分野
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SAWADA S.
広島大学原爆放射能医学研究所放射線基礎研究分野
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IWAMOTO B.
Nisshin High Voltage Co. Ltd.
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SAKAMOTO S.
Nisshin High Voltage Co. Ltd.
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TAKEYAMA K.
Nisshin High Voltage Co. Ltd.
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OMURA M.
Nisshin High Voltage Co. Ltd.
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Nakamura Yusuke
Human genome center
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安藤 興一
Natl. Instit. Rad. Sci. Med.
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Hosokawa Masao
Department Of Gastroenterology Muroran General Hospital
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FURUSAWA Yoshiya
NIRS
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ANDO Koichi
NIRS
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Katoh Osamu
The Division Of Cardiol Sakurabashi Watanabe Hospital
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Katoh O
Department Of Cellular Biology Research Institute For Radiation Biology And Medicine Hiroshima Unive
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Katoh Osamu
広島大学原爆放射能医学研究所
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Uesaka T
Department Of Cellular Biology Research Institute For Radiation Biology And Medicine Hiroshima Unive
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Uesaka Toshihiro
広島大学原爆放射能医学研究所
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Uesaka Tosihiro
広島大学原爆放射能医学研究所
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Iaskova E.
広島大学原爆放射能医学研究所
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Iaskova E.
Medical Radiological Research Center Russian Academy Of Medical Sciences
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Ito A
Department Of Cancer Research Research Institute For Radiation Biology And Medicine Hiroshima Univer
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Ohtaki M
Hiroshima Univ. Hiroshima Jpn
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Ohtaki Megu
Department Of Environment And Biometrics Research Institute For Radiation Biology And Medicine Hiros
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Yumiko Nitta
Research Institute For Radiation Biology And Medicine Hiroshima University
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Nitta Yumiko
広島大学原爆放射能医学研究所附属国際放射線情報センター
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Nitta Yumiko
Hiroshima Univ. Hiroshima
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Sugita Katsuo
Department Of Pediatrics Faculty Of Medicine Chiba University
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Sugita Katsuo
Department Of Clinical Medicine Faculty Of Education Chiba University
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Nakamura Nori
Dep. Of Genetics Radiation Effects Res. Foundation
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TAKATA Minoru
Department of Immunology, Kawasaki Medical School
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HASEGAWA TOMONOBU
Department of Pediatrics, Keio University School of Medicine
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Kamada Nanao
広島大学原爆放射能医学研究所
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Kamada Nanao
Dept. Of Cancer Cytogenetics Research Institute For Radiation Biology &medicine Hiroshima Univer
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FURUSAWA Yoshiya
Space and Prticle Radiation Science Research Group, national Institute of Radiological Science (NIRS
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SUZUKI Masao
Natl. Inst. Radiol. Sci.
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Kamiya Kenji
Res. Inst. Radiat. Biol. Med. Hiroshima Univ.
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IDE Toshinori
Department of Cellular and Molecular Biology, Hiroshima University School of Medicine
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SAWADA SHOZO
Department of Radiation Biology, Research Institute for Radiation Biology and Medicine, Hiroshima Un
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Shoji Shuneki
Department Of Environment And Mutation Research Institute For Radiation Biology And Medicine
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IWABUCHI Kuniyoshi
Department of Biochemistry, Kanazawa Medical University
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MIYAGAWA Kiyoshi
Section of Radiation Biology, Graduate School of Medicine, The University of Tokyo
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SONODA Eiichiro
Department of Radiation Genetics, Faculty of Medicine, Kyoto University
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ITOH Atsushi
Dept. Rad. Biol., RIRBM, Hirosbima Univ., Hiroshima Univ. School of Medicine
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UEDA Miki
Dept. Radiation Biol., RIRBM, Hiroshima Univ.
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KOBAYASHI Junya
2Dentistry Radiol, Hiroshima Univ.
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ANDO Koichi
Dept. Radiation Biol., RIRBM, Hiroshima Univ.
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YAMASHITA Yukiko
Kyoto Univ.
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SONODA Eiichiro
Kyoto Univ.
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TAKATA Minoru
Kyoto Univ.
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TAKEDA Shunichi
Kyoto Univ.
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Ando K
Division Of Health Sciences Graduate School Of Medicine Osaka University
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Ito Akihiro
広島大学原爆放射能医学研究所
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Satow Yukio
Department Of Envrironment And Mutation Division Of Envrionmental Biology Research Institute For Rad
著作論文
- Two Major Factors Involved in the Reverse Dose-rate Effect for Somatic Mutation Induction are the Cell Cycle Position and LET Value
- 242 Analysis of apoptosis induction in Nbs1 deficient cells(Apoptosis related, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 206 Functional Domain Analysis of NBS1 Gene in Homologous Recombinational Repair(Physics, chemistry and DNA damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 182 Effect of gravity stress on homologous recombination(Environmental effects of radiation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 98 Localization of Rad51 protein in cells from patients with Fanconi Anemia D1 group(Repair of radiation damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 19 Analysis of Mutation Induction By Low Dose Rate Tritium Radiation Using Hyper Sensitive Detection System(Low dose and low dose-rate effects, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- S-3-1 Mechanisms of DNA double-strand break repair(Biological Effects of Low Dose and Low Dose-rate Irradiations, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- Analysis of the cell death after irradiation in the cells with defective DNA repair
- Mutation screening for a novel cancer-predisposition syndrome of total PCS
- p53-Binding Protein 1 (53BP1) is Involved in the Repair of DNA Double-Strand Breaks
- Analysis of the function of NBS1 in DNA double-strand break repair
- Histone H2AX regulates the formation of NBS1 foci on DNA damage sites
- Dissociation of ATM/NBS1 functions in telomere maintenance
- NBS1 is involved in recognition of DNA damage and initiation of homologous recombination.
- Bystander mutagenic effect of alpha particle in human-hamster hybrid cells
- Somatic Mutation Caused by Low Dose Rate Tritium Radiation : Studies Using A Hyper-sensitive DetectionSystem
- Complementation studies of immortalized cell lines from infants with total PCS
- Establishement of mouse Nbs1-deficient cell lines by gene targeting
- Estimation of Dose Absorbed Fraction for ^I-bera rays in Rat Thyroid
- Neutron Generator at Hiroshima University for Use in Radiobiology Study
- Association of DNA repair protein NBS1 with telomere maintenance
- The function of NBS1 and histone H2AX in the early process of DNA repair.
- Reversed dose-rate effect of high LET radiation in mutation induction
- Chromosomal instability syndrome of total premature chromatid separation with mosaic variegated aneuploidy is defective in mitotic spindle checkpoint
- Screening of protein interacting with FANCG by Yeast two-hybrid system
- Four novel mutations of the Fanconi anemia group A gene (FAA) in Japanese patients
- Accumulation of Cells at G_2/M Stage by Low Dose-Rate Irradiation Renders the Cell Population More Susceptible to the Subsequent Induction of 6-Thioguanine-Resistant Mutations by ^Cf Fission Neutrons.
- Current Topics in DNA Double-Strand Break Repair
- Functionally important domain analysis of the Nijimegen breakage syndrome gene. NBS1
- Development of a Radio-sensitive Mutation System for the Study of Dose Rate Effects of Space High LET Radiation
- NBS1, the Nijmegen breakage syndrome protein, regulates the localization of DNA repair complex hRAD50/hMRE11/NBS1
- Accelerated telomere shortening by disruption of DNA repair protein NBS1
- Construction of Nbs1 knockout cell line using chicken DT40
- Nijmegen Breakage Syndrome (NBS) gene, NBS1, is involved in telomeric length maintenance.
- Induction of dominant lethality and developmental anomalies in offspring of male mice inadiated to varying doses of ^Cf fission neutrons
- Positional cloning of the gene for Nijmegen breakage syndrome
- Genetic Mapping of Nijmegen Breakage Syndrome using Functional Complementation Assays and Homozygosity Mapping
- Haplotype Analysis of Nijmegen Breakage Syndrome and Construction of Physical Map of Candidate Region.
- Complementation Assay between Radiation-Sensitive irs2 Mutant and Ataxia-Telangiectasia Cell
- The Genetic Homogeneity of Nijmegen Breakage Syndrome V1 and V2.
- Mapping of the underlying gene for rare genetic complementation group Fanconi anemia
- Effect of gravity stress on fidelity of DNA double-strand break repair
- Neutron Generator (HIRRAC) and Dosimetry Study
- Development of a low energy proton irradiation system using HIRRAC
- NBS1 Regulates Apoptosis Induced by γ-Irradiation in Lymphoblastoid
- Mutation screening of the NBS1 gene in sporadic malignant lymphoma
- LET, cell cycle dependence for mutation induction and spectrum in HPRT locus
- Cell Cycle and LET Dependence for Radiation-induced Mutation : A Possible Mechanism for Reversed Dose-rate Effect
- Radiation-induced teratogenicity and embryo lethality in the scid mice.
- Mutation Analysis of the Fanconi Anemia Gene FAA in Japanese patients
- Mutation Analysis of the Fanconi Anemia Genes in Japanese Patients
- Function of NBS1 in Activation of ATM kinase in Response to IR.
- The genetic complementation assay of Nijmegen breakage syndrome witit ataxia telangiectasia on the basis of radiation sensitivity to cell killing.
- Induction of 6-thioguanine-resistant mutations by ^Cf fission neutrons in the cells pre-irradiated at low dose-rate.
- 187 Heavy Water Release Experiments for tritium dose assessment purpose : Translocation of Deuterium into Orange (Citrus unshiu Marc.)(Environmental effects of radiation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 186 Heavy Water Release Experiments in a Greenhouse : Translocation of Deuterium into Unhulled Rice and Its Loss during Growth Process of Rice(Environmental effects of radiation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society
- 172 Characteristics of tritium gas oxidizing bacteria, isolated from cultivated soils, which were classified to belong to the genus Kitasatospora(Environmental effects of radiation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Soci
- 126 Detection of sunlight UV-induced DNA damage in mouse cells with the comet assay(Effects of space radiation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- Assessment of DNA Damage in Tritiated Water Administered Mouse by Comet Assay
- A polymorphic CA repeat marker at the human 27-kD calbindin (CALB1) locus
- Nijmegen breakage syndrome : Sequence analysis of an 800-kb genomic region on chromosome 8q21.
- The relationship between NBS1 and cell death induced by γ-ray irradiation in lymphoblastoid
- Cell cycle and LET dependence for 6-thioguanine-resistant mutation induced by heavy ion beam in mouse L5178Y cells
- 30 Studies on DNA Damage in Lymphocyte, Born marrow, and Spleen of Mouse Exposed to Tritium Assessed byThe Comet Assay
- Genetic heterogeneity of ataxia-telangiectasia-like hamster mutant irs2 with Nijmegen breakage syndrome
- Genetic heterogeneity of ataxia-telangiectasia-like hamster mutant irs2 with Nijmegen breakage syndrome.
- Radiation-induced HPRT mutation of a radiation sensitive hamster cell line irs1SF
- DNA-dependent protein kinase restores mouse scid mutation
- Inhibition of radiation-induced oncogenic transformation in C3H10T1/2 cells by green tea component, (-)-epigallocatechin gal late.
- Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination