Current Topics in DNA Double-Strand Break Repair

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概要

• 論文の詳細を見る

• DNA double strand break (DSB) is one of the most critical types of damage which is induced by ionizing radiation. In this review, we summarize current progress in investigations on the function of DSB repair-related proteins. We focused on recent findings in the analysis of the function of proteins such as 53BP1, histone H2AX, Mus81-Eme1, Fanc complex, and UBC13, which are found to be related to homologous recombination repair or to non-homologous end joining. In addition to the function of these proteins in DSB repair, the biological function of nuclear foci formation following DSB induction is discussed.

• 2008-03-16

著者

• Kobayashi Jyunya

  Department Of Genome Repair Dynamics Radiation Biology Center Kyoto University

• TAUCHI Hiroshi

  Department of Biological Science, Faculty of Science, Ibaraki University

• Suzuki Keiji

  Graduate School Of Biomedical Sciences Nagasaki University

• Tauchi Hiroshi

  Department Of Biological Science Faculty Of Science Ibaraki University

• Tauchi Hiroshi

  Dep. Env. Sci. Fac. Sci. Ibaraki Univ.

• TAKATA Minoru

  Department of Immunology, Kawasaki Medical School

• Takata Minoru

  Dep. Of Late Effects Studies Radiation Biology Center Kyoto Univ.

• Kobayashi Junya

  Department Of Genome Repair Dynamics Radiation Biology Center Kyoto University

• IWABUCHI Kuniyoshi

  Department of Biochemistry, Kanazawa Medical University

• MIYAGAWA Kiyoshi

  Section of Radiation Biology, Graduate School of Medicine, The University of Tokyo

• SONODA Eiichiro

  Department of Radiation Genetics, Faculty of Medicine, Kyoto University

• Takata Minoru

  Immunology And Molecular Genetics Kawasaki Medical School

• Takata Minoru

  Department Of Late Effects Studies Radiation Biology Center Kyoto University

• Takata Minoru

  Department Of Dermatology Kanazawa University School Of Medicine

• Takata Minoru

  Dept. Of Cardiovascular Mol. Biol. Lederle Lab.

• Iwabuchi Kuniyoshi

  Department Of Biochemistry Kanazawa Medical University

• Tauchi Hiroshi

  Dep. Of Biological Sci. Fac. Of Sci. Ibaraki Univ.

• Tauchi Hiroshi

  Div. Environ. Biol. Res. Inst. Rad. Biol. And Med. Hiroshima University

• Sonoda Eiichiro

  Department Of Radiation Genetics Faculty Of Medicine Kyoto University

• Miyagawa Kiyoshi

  Section Of Radiation Biology Graduate School Of Medicine The University Of Tokyo

• Tauchi H

  Department Of Biological Science Faculty Of Science Ibaraki University

• Kobayashi Junya

  Dept. Oral Maxillofac. Rad. Fac. Dent. Hiroshima Univ.

• Tauchi Hiroshi

  Tokyo Institute Of Technology Research Laboratory For Nuclear Reactors

関連論文

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• 206 Functional Domain Analysis of NBS1 Gene in Homologous Recombinational Repair(Physics, chemistry and DNA damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 182 Effect of gravity stress on homologous recombination(Environmental effects of radiation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 98 Localization of Rad51 protein in cells from patients with Fanconi Anemia D1 group(Repair of radiation damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 19 Analysis of Mutation Induction By Low Dose Rate Tritium Radiation Using Hyper Sensitive Detection System(Low dose and low dose-rate effects, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• S-3-1 Mechanisms of DNA double-strand break repair(Biological Effects of Low Dose and Low Dose-rate Irradiations, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Analysis of the cell death after irradiation in the cells with defective DNA repair
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• Analysis of the function of NBS1 in DNA double-strand break repair
• Histone H2AX regulates the formation of NBS1 foci on DNA damage sites
• Dissociation of ATM/NBS1 functions in telomere maintenance
• NBS1 is involved in recognition of DNA damage and initiation of homologous recombination.
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• Somatic Mutation Caused by Low Dose Rate Tritium Radiation : Studies Using A Hyper-sensitive DetectionSystem
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• Mapping of the underlying gene for rare genetic complementation group Fanconi anemia
• Effect of gravity stress on fidelity of DNA double-strand break repair
• Neutron Generator (HIRRAC) and Dosimetry Study
• Development of a low energy proton irradiation system using HIRRAC
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• Mutation Analysis of the Fanconi Anemia Genes in Japanese Patients
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