Neutron Energy-Dependent Initial DNA Damage and Chromosomal Exchange
スポンサーリンク
概要
- 論文の詳細を見る
This study was undertaken to investigate the biological effect of monoenergetic neutrons on human lymphocyte DNA and chromosomes. Monoenergetic neutrons of 2.3, 1.0, 0.79, 0.57, 0.37 and 0.186 MeV were generated, and ^<252>Cf neutrons and ^<60>Coγ-rays were also used for comparison. Biological effect was evaluated two ways. The RBE values with the comet assay were estimated as 6.3 and 5.4 at 0.37 MeV and 0.57 MeV relative to that of ^<60>Coγ-rays, and chromosome aberration rates were also observed in these different levels of monoenergetic neutrons. The yield of chromosome aberrations per unit dose was high at lower neutron energies with a gradual decline with 0.186 MeV neutron energy. The RBE was increased to 10.7 at 0.57 MeV from 3.9 at ^<252>Cf neutrons and reached 16.4 as the highest RBE at 0.37 MeV, but the value decreased to 11.2 at 0.186 MeV. The response patterns of initial DNA damage and chromosome exchange were quite similar to that of LET. These results show that the intensity of DNA damage and chromosomal exchange is LET dependent. RBE of low energy neutrons is higher than that of fission neutrons. Low energy neutrons containing Hiroshima atomic bomb radiation may have created a significantly higher incidence of biological effect in atomic bomb survivors.
- 日本放射線影響学会の論文
著者
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Komatsu Kenshi
Department Of Genome Repair Dynamics Radiation Biology Center Kyoto University
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Kamiya K
Department Of Genome Repair Dynamics Radiation Biology Center Kyoto University
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HOSHI Masaharu
International Radiation Information Center, Research Institute for Radiation Biology and Medicine, H
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Tanaka Kimio
Department Of Physics School Of Medicine Sapporo Medical University
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Tanaka Kimio
Radiation Effect Mechanisms Research Group National Institute Of Radiological Sciences
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遠藤 暁
Mechanical System Engineering Graduate School Of Engineering Hiroshima University
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Endo Satoru
Department Of Biochemistry Cancer Institute Okayama University Medical School
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KAMADA NANAO
Department of Cancer Cytogenetics
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Kamada N
Department Of Cancer Cytogenetics Research Institute For Radiation Biology And Medicine Hiroshima Un
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Kamada Nanao
広島大学原爆放射能医学研究所
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Kamada Nanao
Hiroshima Atomic Bomb Survivors Relief Foundation
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Komatsu Kenshi
Dep. Of Genome Repair Dynamics Radiation Biology Center Kyoto Univ.
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Tanaka K
Department Of Physics School Of Medicine Sapporo Medical University
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Tanaka Kimio
Dep. Of Radiobiology Inst. For Environmental Sciences
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Tanaka Kimio
Department Of Biology Faculty Of Science Konan University
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Kamada Nanao
Research Institute For Radiation Biology &medicine Hiroshima Univ.
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Kamada Nanao
Department Of Hematology Research Institute For Nuclear Medicine & Biology Hiroshima University
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Endo Satoru
Div. Environ. Biol. Res. Inst. Rad. Biol. And Med. Hiroshima University
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GAJENDIRAN NATARAJAN
Department of Cancer Cytogenetics, Research Institute for Radiation Biology and Medicine, Hiroshima
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Hoshi Masaharu
International Radiation Information Center Hiroshima University
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Gajendiran Natarajan
Department Of Cancer Cytogenetics Research Institute For Radiation Biology And Medicine Hiroshima Un
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Kamada Nanao
Dept. Of Cancer Cytogenet. Res. Inst. Rad. Biol. &med. Hiroshima University.
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