Tumor induction by monoenergetic neutrons in B6C3F1 mice
スポンサーリンク
概要
- 論文の詳細を見る
This study was undertaken to investigate induction of tumors by monoenergetic neutrons in B6C3F1 mice. Individual groups of 6 week-old animals of both sexes (about 30 mice/group) were exposed to 0.5 Gy of various monoenergetic neutrons (dose rate 0.5 cGy/min) and then observed for 13 months. The incidences of tumors (mainly liver neoplasms) in non-irradiated male and female controls were 11% and 0%, respectively. In the irradiated animals, the incidences were 53%, 50%, 60% and 43% in males, and 75%, 81%, 71%, and 85% in females, after 0.18, 0.32, 0.6 and 1.0 MeV neutron exposure, respectively. There were no significant differences in the tumor induction rate among the different energy groups
- 日本放射線影響学会の論文
- 2007-05-15
著者
-
Kamiya K
Department Of Genome Repair Dynamics Radiation Biology Center Kyoto University
-
Komatsu Kenshi
Research Institute For Radiation Biology And Medicine Hiroshima University
-
WATANABE Hiromitsu
Department of Cancer Research, Hiroshima University
-
KAMIYA Kenji
Department of Experimental Oncology, Research Institute for Radiation Biology and Medicine, Hiroshim
-
神谷 研二
広島大学原爆放射線医科学研究所 分子発がん
-
KASHIMOTO Naoki
Department of Cellular Biology, Research Institute for Radiation Biology and Medicine, Hiroshima Uni
-
Ishikawa Masayori
広島大学原爆放射線医科学研究所 分子発がん制御研究分野
-
石川 正純
北海道大学
-
石川 正純
東京大学・原子力研究総合センター
-
Ishikawa Masayori
Department Of Medical Physics Hokkaido University Hospital
-
石川 正純
東京大学大学院工学系研究科
-
Kashimoto Naoki
Department Of Experimental Oncology Research Institute For Radiation Biology And Medicine Hiroshima
-
Kashimoto Naoki
広島大学原爆放射線医科学研究所 分子発がん制御研究分野
-
Kashimoto Naoki
Department Of Cellular Biology Research Institute For Radiation Biology And Medicine Hiroshima Unive
-
Watanabe Hiromitsu
広島大学原爆放射能医学研究所
-
Watanabe H
Department Of Experimental Oncology Research Institute For Radiation Biology And Medicine Hiroshima
-
Komatsu Kenshi
Dep. Of Genome Repair Dynamics Radiation Biology Center Kyoto Univ.
-
Komatsu Kensi
Div. Environ. Biol. Res. Inst. Rad. Biol. And Med. Hiroshima University
-
KAJIMURA Junko
Department of Experimental Oncology, Research Institute for Radiation Biology and Medicine, Hiroshim
-
Watanabe Hiromitsu
Dept. Environ. Mutat. Res. Inst. Forradiat. Biol. Med. Hiroshima Univ.
-
Kamiya Kenji
広島大学原爆放射能医学研究所附属国際放射線情報センター
-
Kamiya Kenji
Department Of Developmental Biology And Oncology Research Institute For Radiation Biology And Medici
-
Kamiya K
Hiroshima Univ. Hiroshima Jpn
-
Kamiya Kenji
Department Of Experimental Oncology Research Institute For Radiation Biology And Medicine Hiroshima
-
Kamiya Kenji
Dept. Develop. Biol. And Oncol. Res. Inst. Radiat. Biol. Med. Hiroshima Univ.
-
Kajimura Junko
Department Of Experimental Oncology Research Institute For Radiation Biology And Medicine Hiroshima
-
Komatsu Kenshi
Dept. Radiat. Biol. Res. Inst. For Radiat. Biol. Med. Hiroshimauniv.
-
Komatsu Kenshi
Div. Of Environ. Biol. Res. Inst. Rad. Biol. Med. Hiroshima University.
-
KAJIMURA Junko
Department of Bacteriology, Hiroshima University Graduate School of Biomedical Sciences
関連論文
- 血中コレステロールと味噌--味噌食が食事性代謝障害に及ぼす影響の研究
- 誘発突然変異と損傷乗り越えDNA合成を制御するPCNAのモノユビキチン化反応の解析 (第50回原子爆弾後障害研究会 特集号)
- Two Major Factors Involved in the Reverse Dose-rate Effect for Somatic Mutation Induction are the Cell Cycle Position and LET Value
- 242 Analysis of apoptosis induction in Nbs1 deficient cells(Apoptosis related, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 206 Functional Domain Analysis of NBS1 Gene in Homologous Recombinational Repair(Physics, chemistry and DNA damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 182 Effect of gravity stress on homologous recombination(Environmental effects of radiation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 98 Localization of Rad51 protein in cells from patients with Fanconi Anemia D1 group(Repair of radiation damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 19 Analysis of Mutation Induction By Low Dose Rate Tritium Radiation Using Hyper Sensitive Detection System(Low dose and low dose-rate effects, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- S-3-1 Mechanisms of DNA double-strand break repair(Biological Effects of Low Dose and Low Dose-rate Irradiations, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- Analysis of the cell death after irradiation in the cells with defective DNA repair
- Mutation screening for a novel cancer-predisposition syndrome of total PCS
- p53-Binding Protein 1 (53BP1) is Involved in the Repair of DNA Double-Strand Breaks
- Analysis of the function of NBS1 in DNA double-strand break repair
- Histone H2AX regulates the formation of NBS1 foci on DNA damage sites
- Dissociation of ATM/NBS1 functions in telomere maintenance
- NBS1 is involved in recognition of DNA damage and initiation of homologous recombination.
- The relationship between the minimally deleted region of the mouse chromosome 2 and the murine acutemyeloid leukemia development.
- Bystander mutagenic effect of alpha particle in human-hamster hybrid cells
- Somatic Mutation Caused by Low Dose Rate Tritium Radiation : Studies Using A Hyper-sensitive DetectionSystem
- Complementation studies of immortalized cell lines from infants with total PCS
- Establishement of mouse Nbs1-deficient cell lines by gene targeting
- Association of cells from Fanconi anemia patients with radiation sensitivity
- Estimation of Dose Absorbed Fraction for ^I-bera rays in Rat Thyroid
- Induction of dominant lethality and teratogenesis in F_1 mice following paternal ^Cf neutron-irradiation at pre-meiotic and post-meiotic stages of germ cells.
- Zuckerラットを用いた味噌による脂肪肝の減少効果
- 一般演題29 広島県内原爆被爆者の子供数
- Association of DNA repair protein NBS1 with telomere maintenance
- The function of NBS1 and histone H2AX in the early process of DNA repair.
- Reversed dose-rate effect of high LET radiation in mutation induction
- Chromosomal instability syndrome of total premature chromatid separation with mosaic variegated aneuploidy is defective in mitotic spindle checkpoint
- Screening of protein interacting with FANCG by Yeast two-hybrid system
- Four novel mutations of the Fanconi anemia group A gene (FAA) in Japanese patients
- Accumulation of Cells at G_2/M Stage by Low Dose-Rate Irradiation Renders the Cell Population More Susceptible to the Subsequent Induction of 6-Thioguanine-Resistant Mutations by ^Cf Fission Neutrons.
- 放射線誘発マウス肝癌におけるIGFBP-rP1遺伝子の役割
- 線維芽細胞成長因子受容体2(FGFR2IIIb)の発現回復によるヒト前立腺癌細胞の増殖抑制
- Functionally important domain analysis of the Nijimegen breakage syndrome gene. NBS1
- Development of a Radio-sensitive Mutation System for the Study of Dose Rate Effects of Space High LET Radiation
- NBS1, the Nijmegen breakage syndrome protein, regulates the localization of DNA repair complex hRAD50/hMRE11/NBS1
- Accelerated telomere shortening by disruption of DNA repair protein NBS1
- Construction of Nbs1 knockout cell line using chicken DT40
- 誘発突然変異と損傷乗り越えDNA合成 : REV1の構造と生化学的機能
- 損傷乗り越えDNA合成と発癌 (特集 DNAの損傷・修復と疾患)
- P054 Effect of REV1 on the survival of human cells after various DNA damages(Poster Session)
- W2-2 Effect of REV1 on the survival of human cells after various DNA damages(Workshop(2) : Translesion DNA Synthesis and Mutagenesis)
- 一般演題 2 広島大学「原爆・被ばく関連資料データベース」 の概要と公開の意義
- 放射線発がんのメカニズム (第46回原子爆弾後障害研究会) -- (シンポジウム 原子爆弾後障害研究の将来の展望--これからの10年間に期待される成果)
- シンポジウム-1 広島大学21世紀COEプログラム「放射線災害医療開発の先端的研究教育拠点-ゲノム障害科学に基づく学術基盤の確立と医療展開-」の概要
- マウス肝癌で発現が亢進している新規遺伝子 cis-retinol/androgen dehydrogenase type 3 (CRAD 3) の機能解析
- 一般演題 38 損傷乗り越えDNA合成に関与するヒトREV1タンパク質の生化学的解析
- 放射線誘発DNA損傷修復およびアポトーシスにおけるTIP60ヒストンアセチル化酵素複合体の役割
- マウス肝癌におけるIGFBP-7遺伝子の発現低下
- 誘発突然変異の分子機構
- 低線量被曝と発癌 : 乳癌を中心に
- Control of Ductal vs. Alveolar Differentiation of Mammary Clonogens and Susceptibility to Radiation-Induced Mammary Cancer
- Zuckerラットを用いた味噌による脂肪肝の減少効果
- Nijmegen Breakage Syndrome (NBS) gene, NBS1, is involved in telomeric length maintenance.
- Induction of dominant lethality and developmental anomalies in offspring of male mice inadiated to varying doses of ^Cf fission neutrons
- Positional cloning of the gene for Nijmegen breakage syndrome
- Genetic Mapping of Nijmegen Breakage Syndrome using Functional Complementation Assays and Homozygosity Mapping
- Haplotype Analysis of Nijmegen Breakage Syndrome and Construction of Physical Map of Candidate Region.
- Complementation Assay between Radiation-Sensitive irs2 Mutant and Ataxia-Telangiectasia Cell
- The Genetic Homogeneity of Nijmegen Breakage Syndrome V1 and V2.
- Mapping of the underlying gene for rare genetic complementation group Fanconi anemia
- Effect of gravity stress on fidelity of DNA double-strand break repair
- Neutron Generator (HIRRAC) and Dosimetry Study
- Development of a low energy proton irradiation system using HIRRAC
- A biophysical estimate of radioactive iodine (^I) exposure in the whole body and in the thyroid of newborn, puberty and adult Fischer 344 rats.
- NBS1 Regulates Apoptosis Induced by γ-Irradiation in Lymphoblastoid
- Mutation screening of the NBS1 gene in sporadic malignant lymphoma
- LET, cell cycle dependence for mutation induction and spectrum in HPRT locus
- Cell Cycle and LET Dependence for Radiation-induced Mutation : A Possible Mechanism for Reversed Dose-rate Effect
- Radiation-induced teratogenicity and embryo lethality in the scid mice.
- Mutation Analysis of the Fanconi Anemia Gene FAA in Japanese patients
- Mutation Analysis of the Fanconi Anemia Genes in Japanese Patients
- Kinetics of Mammary Clonogenic Cells and Rat Mammary Cancer Induction by X-rays or Fission Neutrons
- Age-dependent Exposure to Radioactive Iodine (^I) in the Thyroid and Total Body of Newborn, Pubertal and Adult Fischer 344 Rats
- Biophysical Estimation of 131I Absorbed Doses and Changes in Plasma Free T3 and TSH After an ^I Injection in Newborn, Puberty and Adult Rats
- Function of NBS1 in Activation of ATM kinase in Response to IR.
- Neutron Energy-Dependent Initial DNA Damage and Chromosomal Exchange
- Tumor induction by monoenergetic neutrons in B6C3F1 mice
- Over-expressed ZF5 Gene Product, a c-myc-binding Protein Related to GL1-Kruppel Protein, Has a Growth-suppressive Activity in Mouse Cell Lines
- Transgemeration Carcinogenesis in the Progeny of Irradiated Male Mice
- Radiation-induced Apoptotic Cell Death in Human Gastric Epithelial Tumor Cells
- Induction of a Germline Mutation at a Hypervariable Mouse Minisatellite Locus by ^Cf Radiation
- Germline Mutation of a Hypervariable Mouse Minisatellite Locus Induced by Ionizing Radiation
- Characterization of two murine mutants, Del(2)59H and Del (2) Sey3H, which delete the region of a putative tumor suppressor gene of acute myeloid leukemia on chromosome 2
- Analysis of Radialton-Induced Mammary Carcinogenesis : age-dependent development of mammary carcinoma in rats
- The genetic complementation assay of Nijmegen breakage syndrome witit ataxia telangiectasia on the basis of radiation sensitivity to cell killing.
- Analysis of Radjaiton-Induced Mammary Carcinogenesis : Susceptibility of rat mammary glands in different ages
- Analysis of Mierosatellite Loci and Genetic Changes in ^cf and DEN Induced Hepatic Tumors
- Mammary tumor induction by ^Co gamma rays in genetically resistant COPENHAGEN rats
- N-nitrosobis(2-hydroxypropyl)amine(BHP)誘発肺癌モデルに対する霊芝菌糸体培養基熱水抽出物(MAK)の予防効果 (第12回日本未病システム学会論文集)
- 新しい緊急被ばく医療と広島大学の役割--緊急被ばく医療ネットワークと人材育成 (第50回原子爆弾後障害研究会 特集号) -- (特別講演 国際基準への貢献,WHO-REMPAN等の緊急被ばく医療ネットワークについて)
- A Miso (Japanese Soybean Paste) Diet Conferred Greater Protection against Hypertension than a Sodium Chloride Diet in Dahl Salt-Sensitive Rats
- Genetic Analysis of Radiation-induced Mouse Hepatocellular Carcinomas by Differential Display Technique
- A polymorphic CA repeat marker at the human 27-kD calbindin (CALB1) locus
- Nijmegen breakage syndrome : Sequence analysis of an 800-kb genomic region on chromosome 8q21.
- Radiation Induction of Gemline Mutation at a Hypervariable Mouse Minisatellite Locus
- The relationship between NBS1 and cell death induced by γ-ray irradiation in lymphoblastoid
- Cell cycle and LET dependence for 6-thioguanine-resistant mutation induced by heavy ion beam in mouse L5178Y cells