Neutron-Energy-Dependent Cell Survival and Oncogenic Transformation
スポンサーリンク
概要
- 論文の詳細を見る
Both cell lethality and neoplastic transformation were assessed for C3H10Tl/2 cells exposed to neutrons with energies from 0.040 to 13.7 MeV. Monoenergetic neutrons with energies from 0.23 to 13.7 MeV and two neutron energy spectra with average energies of 0.040 and 0.070 MeV were produced with a Van de Graaff accelerator at the Radiological Research Accelerator Facility (RARAF) in the Center for Radiological Research of Columbia University. For determination of relative biological effectiveness (RBE), cells were exposed to 250 kVp X rays. With exposures to 250 kVp X rays, both cell survival and radiationinduced oncogenic transformation were curvilinear. Irradiation of cells with neutrons at all energies resulted in linear responses as a function of dose for both biological endpoints. Results indicate a complex relationship between RBEm and neutron energy. For both survival and transformation, RBEm was greatest for cells exposed to 0.35 MeV neutrons. RBEm was significantly less at energies above or below 0.35 MeV. These results are consistent with microdosimetric expectation. These results are also compatible with current assessments of neutron radiation weighting factors for radiation protection purposes. Based on calculations of dose-averaged LET, 0.35 MeV neutrons have the greatest LET and therefore would be expected to be more biologically effective than neutrons of greater or lesser energies.
- 日本放射線影響学会の論文
著者
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Komatsu Kenshi
Department Of Genome Repair Dynamics Radiation Biology Center Kyoto University
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Komatsu K
Hiroshima Univ. Hiroshima Jpn
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Komatsu K
Department Of Genome Repair Dynamics Radiation Biology Center Kyoto University
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Brenner David
Center For Radiological Research Columbia University
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Brenner David
Center For Radiological Res.
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Komatsu Kenshi
Dep. Of Genome Repair Dynamics Radiation Biology Center Kyoto Univ.
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Komatsu Kenshi
Department Of Radiation Biology Research Institute For Radiation Biology And Medicine Hiroshima Univ
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Miller Richard
Center For Radiological Research College Of Physicians And Surgeons Of Columbia University
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MARINO STEPHEN
Center for Radiological Research, College of Physicians and Surgeons of Columbia University
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MARTlN STEWART
CRC Dept. of Clinical Oncology, The University of Nottingham, City Hospital
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GEARD CHARLES
Center for Radiological Research, College of Physicians and Surgeons of Columbia University
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HALL ERIC
Center for Radiological Research, College of Physicians and Surgeons of Columbia University
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Brenner David
Center For Radiological Research College Of Physicians And Surgeons Of Columbia University
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Hall Eric
Center For Radiological Research College Of Physicians And Surgeons Of Columbia University
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Geard Charles
Center For Radiological Res.
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Geard Charles
Center For Radiological Research College Of Physicians And Surgeons Of Columbia University
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Martln Stewart
Crc Dept. Of Clinical Oncology The University Of Nottingham City Hospital
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Marino Stephen
Center For Radiological Research College Of Physicians And Surgeons Of Columbia University
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Komatsu Kenshi
Div. Of Environ. Biol. Res. Inst. Rad. Biol. Med. Hiroshima University.
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