Emerging Connection Between Centrosome and DNA Repair Machinery
スポンサーリンク
概要
- 論文の詳細を見る
Centrosomes function in proper cell division in animal cells. The centrosome consists of a pair of centrioles and the surrounding pericentriolar matrix (PCM). After cytokinesis, daughter cells each acquire one centrosome, which subsequently duplicates at the G1/S phase in a manner that is dependent upon CDK2/cyclin-E activity. Defects in the regulation of centrosome duplication lead to tumorigenesis through abnormal cell division and resulting inappropriate chromosome segregation. Therefore, maintenance of accurate centrosome number is important for cell fate. Excess number of centrosomes can be induced by several factors including ionizing radiation (IR). Recent studies have shown that several DNA repair proteins localize to the centrosome and are involved in the regulation of centrosome number possibly through cell cycle checkpoints or direct modification of centrosome proteins. Furthermore, it has been reported that the development of microcephaly is likely caused by defective expression of centrosome proteins, such as ASPM, which are also involved in the response to IR. The present review highlights centrosome duplication in association with genotoxic stresses and the regulatory mechanism mediated by DNA repair proteins.
- 日本放射線影響学会の論文
- 2009-07-16
著者
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Komatsu Kenshi
Department Of Genome Repair Dynamics Radiation Biology Center Kyoto University
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SHIMADA Mikio
Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University
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Shimada Mikio
Department Of Genome Repair Dynamics Radiation Biology Center Kyoto University
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Shimada Mikio
京都大学放射線生物研究センター
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