Ectopic Neurons in the Hippocampus may be a Cause of Learning Disability after Prenatal Exposure to X-rays in Rats
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概要
- 論文の詳細を見る
The relationship between an impairment of spatial navigation and an incidence of ectopic neurons in the dorsal hippocampus was investigated in adult rats that were prenatally exposed to X-ray irradiation. Adult rats which had received 1.5 Gy X-rays at embryonic day 15 (E15) showed significant learning disability in the water-maze task. According to the mean value of the swimming time, we categorized the irradiated adult rats into the following three groups : slightly damaged group, mildly damaged group and severely damaged group. No significant difference in the brain weight was found between the three categorized groups. Ectopic neurons appearing at abnormal places were prominently observed in the dorsal hippocampus of the severely damaged group with a remarkable learning disturbance, while no ectopia in the hippocampus was observed in the slightly damaged group. This may suggest that the cognitive dysfunction induced by prenatal exposure to X-ray irradiation may be, at least in part, attributable to ectopic neurons of the hippocampus.
- 日本放射線影響学会の論文
著者
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Mishima Kenichi
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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安藤 興一
放医研
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安藤 興一
学振科技特
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安藤 興一
Natl. Instit. Rad. Sci. Med.
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Ando Koichi
Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences
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TAKAI Nobuhiko
Heavy-ion Radiobio. Res. Grp., Natl Inst. Radiol. Sci.
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Sun X‐z
National Inst. Of Radiological Sci. Chiba Jpn
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Sun Xue-zhi
徳島大学 医学部機能解剖学
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Takahashi Sentaro
Research Center For Radiation Safety National Institute Of Radiological Sciences
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Ando K
Division Of Health Sciences Graduate School Of Medicine Osaka University
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Sun Xue-zhi
Brain Research Project National Institute Of Radiological Sciences
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Ando Koichi
Heavy-ion Radiobiology Res. Group National Inst. Of Radiological Sciences
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Takai Nobuhiko
Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences
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Ando Soichiro
National Institute Of Radiological Sciences
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Ando Koichi
Department Of Technical Support And Development Natl. Inst. Radiol. Sci.
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Ando Koichi
Space And Particle Radiation Science Research Group National Institute Of Radiological Sciences
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Mishima Kenichi
Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Ando Koichi
Division Of Health Sciences Graduate School Of Medicine Osaka University
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Takahashi S
Department Of Pediatrics And Child Health Nihon University School Of Medicine
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Takai Nobuhiko
Department Of Molecular And Cellular Pharmacology Nagoya City University
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SUN Xue
Brain Research Project, National Institute of Radiological Sciences
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TAKAHASHI Sentaro
Brain Research Project, National Institute of Radiological Sciences
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Mishima Kenichi
Department Of Chemical Engineering Faculty Of Engineering Fukuoka University
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Ando Koichi
Heavy-ion Radio. Res. Nirs
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Ando Koichi
International Space Radiation Laboratory National Institute Of Radiological Sciences
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Takahashi Sentaro
Brain Research Project National Institute Of Radiological Sciences
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