The Cannabinoid 1–Receptor Silent Antagonist O-2050 Attenuates Preference for High-Fat Diet and Activated Astrocytes in Mice
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概要
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Endocannabinoids have been shown to activate reward-related feeding and to promote astrocytic differentiation. We investigated whether high-fat diet (HFD) intake produced a preference for HFD via an endocannabinoid-dependent mechanism. In the conditioned place preference test, the 2-week HFD–intake group showed preference for HFD and had increased expression of a marker for reactive astrocytes, glial fibrillary acid protein (GFAP), in the hypothalamus. The cannabinoid CB1–receptor antagonist O-2050 reduced the preference for HFD and expression of GFAP in the hypothalamus. These results suggested that HFD intake led to the development of a preference for HFD via astrocytic CB1 receptors in the hypothalamus.
著者
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Irie Keiichi
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Akitake Yoshiharu
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Mishima Kenji
Department of Chemical Engineering, Fukuoka University
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Mishima Kenichi
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Fujiwara Michihiro
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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IWASAKI Katsunori
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Higuchi Sei
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
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Mishima Shohei
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
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Araki Maiko
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
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Ohji Makiko
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
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Shirakawa Atsunori
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
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Matsuyama Kiyoshi
Department of Chemical Engineering, Faculty of Engineering, Fukuoka University, Japan
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Iwasaki Katsunori
Dep. Of Neuropharmacology Fac. Of Pharmaceutical Sciences Fukuoka Univ.
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Irie Keiichi
Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Matsuyama Kiyoshi
Department Of Chemical Engineering Fukuoka University
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Iwasaki Katsunori
Department Of Mathematical Sciences The University Of Tokyo
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Mishima Kenichi
Department Of Chemical Engineering Faculty Of Engineering Fukuoka University
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Iwasaki Katunori
Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Higuchi Sei
Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Araki Maiko
Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Fujiwara Michihiro
Department Of Neuroparmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Ohji Makiko
Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Mishima Shohei
Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Akitake Yoshiharu
Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Shirakawa Atsunori
Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Mishima Kenji
Department Of Chemical Engineering Fukuoka University
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Mishima Kenji
Department of Chemical Engineering, Faculty of Engineering, Fukuoka University, Japan
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Akitake Yoshiharu
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
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Irie Keiichi
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
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Iwasaki Katsunori
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
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- The Cannabinoid 1–Receptor Silent Antagonist O-2050 Attenuates Preference for High-Fat Diet and Activated Astrocytes in Mice