PHARMACOLOGICAL CHARACTERISTICS OF ABNORMAL BEHAVIOR INDUCED BY HARMINE WITH SPECIAL REFERENCE TO TREMOR IN MICE
スポンサーリンク
概要
- 論文の詳細を見る
Harmine, a hallucinogen with potent monoamine oxidase inhibitory properties, induced abnormal behavior, including tremor, scratching, head twitch and cage biting, in the mouse. A dose-dependent tremor was produced by all routes of administration of harmine. Although oxotremorine tremor was markedly suppressed by atropine, harmine tremor was unaffected by cholinergic drugs, remarkably inhibited by dopaminergic drugs, antidepressants and diazepam, mildly diminished by p-chlorophenylalanine, markedly augmented by 5-hydroxytrptophan and mildly increased by α-methyl-p-tyrosine. These findings suggest that a catecholaminergic (particularly dopaminergic) and serotonergic system imbalance plays an important role in the manifestation of harmine tremor. In view of these characteristics, harmine tremor may be useful as an effective experimental model for the evaluation of antiparkinsonism drugs, along with oxotremorine tremor because of the different mechanism of occurrence. In addition, harmine tremor appears to be useful in characterizing the properties of antidepressant drugs.
- 公益社団法人日本薬学会の論文
著者
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Fujiwara Michihiro
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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KATAOKA Yasufumi
Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka U
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UEKI Showa
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University
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Fujiwara Michihiro
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyushu University
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Ueki Showa
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyushu University
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Kawanishi Kazuko
Department Of Pharmacognosy Kobe Women's College Of Pharmacy
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HASHIMOTO YOHEI
Department of Pharmacognosy, Kobe Women's College of Pharmacy
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Hashimoto Yohei
Department Of Pharmacognosy Kobe Women's College Of Pharmacy
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Kataoka Yasufumi
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Fujiwara Michihiro
Department Of Neuroparmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Hashimoto Yohei
Department Of Bioresource Science Mie University
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Kawanishi Kazuko
Department of Natural Medicinal Chemistry, Kobe Pharmaceutical University
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UEKI Showa
Department of Phamacology, Faculty of Pharmaceutical Sciences, Kyushu University
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