Soybean Isoflavones Eliminate Nifedipine-Induced Flushing of Tail Skin in Ovariectomized Mice
スポンサーリンク
概要
- 論文の詳細を見る
Hot flushes are one of the most frequent symptoms in menopausal women. We investigated effect of soybean isoflavones (Soyaflavone HG) on nifedipine-induced flushing in ovariectomized mice. Ovariectomy markedly aggravated nifedipine-induced increase in tail skin temperature. Soyaflavone HG (10 mg/kg, p.o., once a day for 5 days) inhibited nifedipine-induced flushing in ovariectomized mice. The inhibitory effect of Soyaflavone HG was significantly reversed by an estrogen-receptor antagonist, ICI 182,780, suggesting that Soyaflavone HG prevents nifedipine-induced flushing partially through estrogen receptors. We presented the experimental evidence suggesting that soybean isoflavones including Soyaflavone HG have the benefits for menopausal hot flushes.
- 社団法人 日本薬理学会の論文
- 2004-08-20
著者
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Yamauchi Atsushi
Department of Cardiovascular Medicine, Asahikawa Medical College
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Kai Hisashi
久留米大学 医学部心臓･血管内科
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Kai Hisashi
Department Of Internal Medicine Division Of Cardio-vascular Medicine Kurume University School Of Med
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KAI Mamiko
Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka U
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KATAOKA Yasufumi
Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka U
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Tominaga Koji
Department Of Industrial Chemistry Faculty Of Engineering Chubu University
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Tominaga Koji
Department Of Pharmaceutical Care And Health Sciences Faculty Of Pharmaceutical Sciences Fukuoka Uni
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Higashiura Katsuhiro
Second Department Of Internal Medicine Sapporo Medical University School Of Medicine
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Kai Hisashi
Internal Medicine III, Kurume University School of Medicine
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Kai Hisashi
Internal Medicine Iii Kurume University School Of Medicine
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KOGA Ayako
Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka U
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Yamauchi Atsushi
Department Of Cardiology Asahikawa Medical College
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Yamauchi Atsushi
Department Of Pharmaceutical Care And Health Sciences Faculty Of Pharmaceutical Sciences Fukuoka Uni
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Kai Mamiko
Department Of Pharmaceutical Care And Health Sciences Faculty Of Pharmaceutical Sciences Fukuoka Uni
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Kataoka Y
Department Of Pharmaceutical Care And Health Sciences Faculty Of Pharmaceutical Sciences Fukuoka Uni
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Kataoka Yasufumi
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Kataoka Yasufumi
Department Of Pharmaceutical Care And Health Sciences Faculty Of Pharmaceutical Sciences Fukuoka Uni
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Kataoka Yasufumi
Faculty Of Pharmaceutical Sciences Fukuoka University
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Koga Ayako
Department Of Pharmaceutical Care And Health Sciences Faculty Of Pharmaceutical Sciences Fukuoka Uni
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Yamauchi Atsushi
Department Of Pharmaceutical Care And Health Sciences Faculty Of Pharmaceutical Sciences Fukuoka Uni
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Yamauchi Atsushi
Department Of Biology Faculty Of Science Kyushu University
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Tominaga Kohji
Department Of Pharmaceutical Care And Health Sciences Faculty Of Pharmaceutical Sciences Fukuoka Uni
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Kataoka Yasufumi
Department Of Pharmaceutical Care And Health Sciences Faculty Of Pharmaceutical Sciences Fukuoka Uni
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