Protective Action of Indapamide, a Thiazide-Like Diuretic, on Ischemia-Induced Injury and Barrier Dysfunction in Mouse Brain Microvascular Endothelial Cells
スポンサーリンク
概要
- 論文の詳細を見る
The aim of the present study was to elucidate the effects of indapamide on ischemic damage to the blood-brain barrier (BBB) in vitro. The ischemia/reperfusion conditions employed here significantly decreased the viability of mouse brain capillary endothelial (MBEC4) cells, an effect ameliorated by indapamide. Ischemia increased the permeability of MBEC4 cells to two cellular transport markers, sodium fluorescein and Evan’s blue-albumin. Indapamide reduced the ischemia-induced hyperpermeability of cells. These results suggest that indapamide may have a protective role against ischemia-induced injury and dysfunction of the BBB.
- 社団法人 日本薬理学会の論文
- 2007-03-20
著者
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Yamauchi Atsushi
Department of Cardiovascular Medicine, Asahikawa Medical College
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TSURUO TAKASHI
Institute of Molecular and Cellular Biosciences, University of Tokyo
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KATAOKA Yasufumi
Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka U
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NAITO Mikihiko
Institute of Molecular and Cellular Biosciences, The University of Tokyo
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SHUTO Hideki
Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University
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Tsuruo Takashi
Institute Of Molecular And Cellular Biosciences The University Of Tokyo
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Tsuruo Takashi
Institute Of Molecular And Cellular Biosciences University Of Tokyo
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Shuto Hideki
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Shuto Hideki
Department Of Pharmaceutical Care And Health Sciences Faculty Of Pharmaceutical Sciences Fukuoka Uni
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Naito Mikihiko
Institute Of Molecular And Cellular Biosciences University Of Tokyo
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Naito Mikihiko
Institute Of Molecular And Cellular Biosciences The University Of Tokyo
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NISHIOKU Tsuyoshi
Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka U
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TAKATA Fuyuko
Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka U
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SUMI Noriko
Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka U
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YAMAMOTO Ikumi
Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka U
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FUJINO Akiko
Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka U
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Sumi Noriko
Department Of Pharmaceutical Care And Health Sciences Faculty Of Pharmaceutical Sciences Fukuoka Uni
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Fujino Akiko
Department Of Pharmaceutical Care And Health Sciences Faculty Of Pharmaceutical Sciences Fukuoka Uni
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Takata Fuyuko
Department Of Pharmaceutical Care And Health Sciences Faculty Of Pharmaceutical Sciences Fukuoka Uni
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Yamamoto Ikumi
Department Of Pharmaceutical Care And Health Sciences Faculty Of Pharmaceutical Sciences Fukuoka Uni
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Yamauchi Atsushi
Department Of Cardiology Asahikawa Medical College
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Yamauchi Atsushi
Department Of Pharmaceutical Care And Health Sciences Faculty Of Pharmaceutical Sciences Fukuoka Uni
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Kataoka Y
Department Of Pharmaceutical Care And Health Sciences Faculty Of Pharmaceutical Sciences Fukuoka Uni
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Kataoka Yasufumi
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Kataoka Yasufumi
Department Of Pharmaceutical Care And Health Sciences Faculty Of Pharmaceutical Sciences Fukuoka Uni
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Kataoka Yasufumi
Faculty Of Pharmaceutical Sciences Fukuoka University
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Yamauchi Atsushi
Department Of Pharmaceutical Care And Health Sciences Faculty Of Pharmaceutical Sciences Fukuoka Uni
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Yamauchi Atsushi
Department Of Biology Faculty Of Science Kyushu University
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Shuto Hideki
Department Of Pharmaceutical Care And Health Sciences Faculty Of Pharmaceutical Sciences Fukuoka Uni
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Kataoka Yasufumi
Department Of Pharmaceutical Care And Health Sciences Faculty Of Pharmaceutical Sciences Fukuoka Uni
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Yamamoto Ikumi
Department Of Oral And Maxillofacial Surgery Nara Medical University
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Nishioku Tsuyoshi
Department Of Pharmaceutical Care And Health Sciences Faculty Of Pharmaceutical Sciences Fukuoka University
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YAMAMOTO Ikumi
Department of Food and Nutrition, Ochanomizu University
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