Molecular Cancer Therapeutics : Recent Progress and Targets in Drug Resistance
スポンサーリンク
概要
- 論文の詳細を見る
Recent progress in development of molecular cancer therapeutics revealed new types of antitumor drugs, such as Herceptin, Gleevec, and Iressa as potent therapeutics for each specific tumor. We have been working on molecular cancer therapeutics, and in particular, those related to drug resistance, Here, I describe several resistance mechanisms, including apoptosis regulation, cellular stress response and cellular survival signals which have show close relevance to drug resistance. Pglycoprotein (P-gp) is the key molecule in multidrug resistance (MDR) and a good target for chemotherapy. Proteasome is involved in the resistance mechanismto topo II-targeted chemotherapy in solid tumors. Apoptosis program in tumor cells plays a critical role in chemotherapy- induced tumor cell killing, and the blockade of the apoptosis-inducing pathway could be another mechanism for drug resistance. Glyoxalase I is a molecule involved in apoptosis resistance mechanism in tumors. Survival (antiapoptosis) signals are the good targets for various antitumor drugs to over comeinnate drug resistance. Our present studies provide novel targets for effective molecular cancer therapeutics in future.(Internal Medicine 42: 237-243, 2003)
- 社団法人 日本内科学会の論文
- 2003-03-01
著者
関連論文
- Decreased Synthesis of Matrix Metalloproteinase-7 and Adhesion to the Extracellular Matrix Proteins of Human Colon Cancer Cells Treated with Troglitazone
- Prediction of Sensitivity to STI571 among Chronic Myeloid Leukemia Patients by Genome-wide cDNA Microarray Analysis
- Clonal Endothelial Cells Produce Humoral Factors that Inhibit Osteoclast-Like Cell Formation In Vitro
- Involvement of mitochondrial aggregation in arsenic trioxide (As_2O_3)-induced apoptosis in human glioblastoma cells
- MOLECULAR TARGETING THERAPY OF CANCER : DRUG RESISTANCE, APOPTOSIS AND SURVIVAL SIGNAL
- Molecular targeting therapy of cancer : drug resistance, apoptosis and survival signal
- Expressions of Cell Cycle Regulators in Human Colorectal Cancer Cell Lines
- Multidrug Resistance Reversal Activity of Taxoids from Taxus cuspidata in KB-C2 and 2780AD Cells
- A New Quinoline Derivative MS-209 Reverses Multidrug Resistance and Inhibits Multiorgan Metastases by P-glycoprotein-expressing Human Small Cell Lung Cancer Cells
- Structure-antitumor Activity Relationship of Semi-synthetic Spicamycin Derivatives
- Combination Therapy with Antibody and Interleukin-2 Gene Transfer against Multidrug-resistant Cancer Cells
- Transduction of the Macrophage Colony-stimulating Factor Gene into Human Multidrug Resistant Cancer Cells : Enhanced Therapeutic Efficacy of Monoclonal Anti-P-glycoprotein Antibody in Nude Mice
- Immunological Quantitation of DT-Diaphorase in Carcinoma Cell Lines and Clinical Colon Cancers : Advanced Tumors Express Greater Levels of DT-Diaphorase
- Reversal of Multidrug Resistance by Novel Nitrophenyl Pyrones, SNF4435C and D
- Establishment of a Hepatocyte Cell Line Producing Growth-promoting Factors for Liver-colonizing Tumor Cells
- A New Taxoid from a Callus Culture of Taxus cuspidata as an MDR Reversal Agent
- Inhibition of Tumor Cell Invasion and Matrix Degradation by Aminopeptidase Inhibitors
- Inhibitory effects of n-3 polyunsaturated fatty acids on sigmoid colon cancer transformants
- Protective Action of Indapamide, a Thiazide-Like Diuretic, on Ischemia-Induced Injury and Barrier Dysfunction in Mouse Brain Microvascular Endothelial Cells
- Establishment and Characterization of Non-small Cell Lung Cancer Cell Lines Resistant to Mitomycin C under Aerobic Conditions
- Inhibition of the Association with Nuclear Matrix of pRB, p70 and p40 Proteins Along with the Specific Suppression of c-MYC Expression by Geldanamycin, an Inhibitor of Sre Tyrosine Kinase
- Aureobasidins as New Inhibitors of P-Glycoprotein in Multidrug Resistant Tumor Cells
- Modulation of Multidrug Resistance by SDZ PSC 833 in Leukemic and Solid-tumor-bearing Mouse Models
- Molecular Cancer Therapeutics : Recent Progress and Targets in Drug Resistance
- Tolbutamide Uptake Via pH- and Membrane-potential-dependent Transport Mechanism in Mouse Brain Capillary Endothelial Cell Line
- Histochemical Detection of Sugar Residues by Joint Use of Specific Antibodies and Lectins
- Caspase-independent necrotic cell death induced by a radiosensitizer, 8-nitrocaffeine