A New Taxoid from a Callus Culture of Taxus cuspidata as an MDR Reversal Agent

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概要

• 論文の詳細を見る

• A new taxoid, 5α,13α-diacetoxy-10β-cinnamoyloxy-4 (20), 11-taxadien-9α-ol (1) along with its 9, 10-isomer, taxinine NN-11 (2) were isolated from the callus cultures of Taxus cuspidata. The structures were identified by the analyses of the spectral data and chemical method. Their in vitro cytotoxicity against 3 cell lines (HepG2, WI-38 and VA-13) and multidrug resistance (MDR) reversal activity toward 2780AD tumor cells were preliminarily evaluated, the low cytotoxicities and potent MDR reversal activities suggested that they might be good lead compounds of tumor MDR reversal agent.

• 公益社団法人日本薬学会の論文
• 2006-03-01

著者

• TSURUO TAKASHI

  Institute of Molecular and Cellular Biosciences, University of Tokyo

• Hirose Katsutoshi

  KNC Laboratories Co., Ltd.

• Takeshita A

  The Third Department Of Internal Medicine Hamamatsu University School Of Medicine

• Tomida Akihiro

  癌研究会癌化学療法センター

• SAKAI Junichi

  Department of Ophthalmology Tokyo Medical College Hospital

• Hasegawa Toshiaki

  Graduate School Of Science And Technology Niigata University

• Ando Masayoshi

  Department of Applied Chemistry, Niigata University

• Sakai Junichi

  Department Of Chemistry And Chemical Engineering Niigata University

• Kiuchi Miwa

  Center For Instrumental Analysis Hokkaido University

• OKA Seiko

  Center for Instrumental Analysis Hokkaido University

• DAI Jungui

  Department of Chemistry and Chemical Engineering, Niigata University

• BAI Jiao

  Graduate School of Science and Technology, Niigata University

• NISHIZAWA Shigenori

  Graduate School of Science and Technology, Niigata University

• HIROSE Katutoshi

  Kobe Natural Products and Chemicals Co., Ltd.

• TOMIDA Akihiro

  Division of Genome Research, Cancer Chemotherapy Center

• LI Minjie

  Graduate School of Science and Technology, Niigata University

• Tsuruo Takashi

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• Bai Jiao

  Graduate School Of Science And Technology Niigata University

• Li Minjie

  Graduate School Of Science And Technology Niigata University

• Dai Jungui

  Department Of Chemistry And Chemical Engineering Niigata University:institute Of Materia Medica Chin

• Takeshita Akihiro

  Department Of Medicine Iii Hamamatsu University School Of Medicine

• Hirose Katutoshi

  Knc Laboratories Co. Ltd.

• Nishizawa Shigenori

  Graduate School Of Science And Technology Niigata University

• Sakai Junichi

  Department Of Chemistry And Chemical Engineering Faculty Of Engineering Niigata University

• Ando Masayoshi

  Department Of Chemistry And Chemical Engineering Faculty Of Engineering Niigata University

• Toki Asami

  Graduate School Of Science And Technology Niigata University

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