The total syntheses of chamaecynone, isochamaecynone, and dihydroisochamaecynone.

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概要

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• A novel acetylenic nor-sesquiterpene, chamaecynone, and its related natural products, isochamaecynone and dihydroisochamaecynone, have been synthesized starting from α-santonin. In the base-induced equilibration of three pairs of compounds, chamaecynone and isochamaecynone, 4β<I>H</I>,5β-13-noreudesm-11-yn-3-one and 4α<I>H</I>,5β-13-noreudesm-11-yn-3-one, and 4β<I>H</I>,5β-13-noreudesm-11-en-3-one and 4α<I>H</I>,5β-13-noreudesm-11-en-3-one, the Δ<I>H</I> values were determined to be +1.47 kcal/mol, +0.77 kcal/mol, and −2.28 kcal/mol respectively.

• 公益社団法人 日本化学会の論文

著者

• Ando Masayoshi

  Department of Applied Chemistry, Niigata University

• Takase Kahei

  Department Of Chemistry Faculty Of Science Tohoku University

• Nozoe Tetsuo

  Department of Chemistry Faculty of Science Tohoku University

• Asao Toyonobu

  Department of Chemistry Faculty of Science Tohoku University

• Hiratsuka Norio

  Department of Chemistry, Faculty of Science, Tohoku University

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