Synthesis and the spectral analysis of 4- and 6-(1-acetamido-3-(3,4,5-trimethoxyphenyl)propyl)-2-methoxytropones (B-ring-open analogues of colchicine).
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概要
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The treatment of 4-[1-acetamido-3-(3,4,5-trimethoxyphenyl)propyl]tropolone with ethereal diazomethane gave the 6- and 4-substituted title compounds in 51 and 38% yields, respectively. The 270-MHz <SUP>1</SUP>H-NMR spectral analysis performed on these compounds, colchicine, and two methyl ethers of hinokitiol permits unequivocal assignment of the position of the <I>C</I>-substituent on these 2-methoxytropone rings. Attempts were made to effect the direct B-ring closure of these intermediates and 4-[1-acetamido-3-(3,4,5-trimethoxyphenyl)propyl]-5-aminotropolone using various oxidizing reagents.
- 公益社団法人 日本化学会の論文
著者
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Hara Atsushi
Department Of Astrophysics Nagoya University
-
Yamamoto Hiroshi
Departmemt Of Chemical Engineering University Of Tokyo
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Nozoe Tetsuo
Department of Chemistry Faculty of Science Tohoku University
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Inokawa Saburo
Department of Chemistry Faculty of Science Kyoto University
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