Peripheral Administration of Magnesium Sulfate and Ketamine Hydrochloride Produces Hypesthesia to Mechanical Stimuli in Humans

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概要

• 論文の詳細を見る

• We investigated the functional significance of peripherally distributed glutamate, including N-methyl-D-aspartate (NMDA), receptors in humans. Magnesium sulfate (MG) and ketamine hydrochloride (KET), NMDA receptor antagonists, were injected into the skin of the medial region of forearm of healthy volunteers to investigate whether these substances are capable of changing the sensory transmission. We found that intracutaneous injections of MG and KET cause hypesthesia to noxious and innoxious mechanical stimulations. These results suggest that peripheral NMDA receptors are involved not only in sensory acceptance of noxious mechanical stimulation, but also in transmission of innoxious mechanical stimuli. The observation that the state of NMDA receptors in the skin may be affected by intracutaneous injection of their antagonists lays ground for possible clinical applications.

• 公益社団法人日本薬学会の論文
• 2002-02-01

著者

• YAMAMOTO Hiroshi

  Department of Macromolecular Science, Graduate School of Science, Osaka University

• USHIDA Takahiro

  Department of Orthopaedic Surgery, Kochi Medical School, Kochi, Japan

• TANI Toshikazu

  Department of Orthopaedic Surgery, Kochi Medical School, Kochi, Japan

• Yamamoto Hiroyuki

  Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka

• Ushida Takahiro

  Multidisciplinary Pain Center Aichi Medical University

• Tani Toshikazu

  Department Of Orthopaedic Surgery Kochi Medical School

• Tani Toshikazu

  Devartment Of Orthovaedic Sureery. Kochi Medical School

• Tani Toshikazu

  Department Of Orthopaedics Kochi Medical School

• Yamamoto H

  Sharp Corp. Nara Jpn

• Yamamoto H

  College Of Science And Technology Nihon University

• Iwatsu Osamu

  Department Of Orthopedic Surgery Kochi Medical School

• Yamamoto H

  Laboratory Of Bioorganic Chemistry School Of Pharmaceutical Sciences University Of Shizuoka

• Yamamoto Hiroshi

  Department Of Energy Engineering And Science Nagoya University

• Nada Bashir

  Department of Anatomy and Neuroscience, University Texas Medical Branch, 301 University Boulevard

• Ushida Takahiro

  Department Of Anatomy And Neurosciences University Of Texas Medical Branch

• Nada Bashir

  Department Of Anatomy And Neuroscience University Texas Medical Branch 301 University Boulevard

• Yamamoto Hitoshi

  Department Of Chemistry Faculty Of Engineering Gifu University

• Yamamoto Hiroshi

  Departmemt Of Chemical Engineering University Of Tokyo

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