Enzymatic Preparation of Chiral 4-Hydroxy-2,2-dimethyl-1-cyclohexanone as a Chiral Building Block(Organic Chemistry)
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概要
- 論文の詳細を見る
(S)-4-Hydroxy-2,2-dimethyl-1-cyclohexanone (1a) was prepared by two enzymatic methods. 1,4-Cyclohexanediol was converted to monoacetal (11) via (±)-1a. Enzymatic reduction of 11 by baker's yeast gave (S)-1 of almost 100 % e.e. Direct hydroxylation of 2,2-dimethyl-1-cyclohexanone (14) by P-450 camphor monooxygenase of the cloned genes of Pseudomonas putida PpG1 gave (S)-1a of almost 100% e.e., too. According to Mitsunobu's method, S_N-2 inversion of (S)-1 gave (R)-1.
- 社団法人日本農芸化学会の論文
- 1990-08-23
著者
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YAMAMOTO Hiroshi
Department of Macromolecular Science, Graduate School of Science, Osaka University
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KOGA HIDEO
Faculty of Pharmaceutical Sciences, Kyushu University
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HORIUCHI TADAO
Faculty of Pharmaceutical Sciences, Kyushu University
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YAMASHITA Kyohei
Department of Agricultural Chemistry, Faculty of Agriculture, Tohoku University
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Yamamoto H
Department Of Applied Biology Faculty Of Textile Science And Technology Shinshu University
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ORITANI Takayuki
Department of Applied Biological Chemistry, Faculty of Agriculture
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Yamashita K
Tohoku Univ. Sendai Jpn
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Koga Hideo
Faculty Of Pharmaceutical Sciences Kyushu University
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Yamamoto H
Department Of Developmental Biology And Neurosciences Graduate School Of Life Sciences Tohoku Univer
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Horiuchi Tadao
Faculty Of Pharmaceutical Sciences Kyushu University
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Yamashita Kyohei
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
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Yamamoto Hiroshi
Department Of Energy Engineering And Science Nagoya University
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Yamamoto H
Department Of Mechanical Engineering Doshisha University
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Koga H
Faculty Of Pharmaceutical Sciences Kyushu University
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Oritani Takayuki
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
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Yamamoto Hiroshi
Departmemt Of Chemical Engineering University Of Tokyo
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