EFFECTS OF DEHYDROEPIANDROSTERONE ACETATE ADMINISTRATION ON POSTMENOPAUSAL WOMEN WITH GYNECOLOGICAL MALIGNANCIES : As chiefly observed in Variations of Serum Dehydroepiandrosterone, Its sulfate, and 11-Deoxy-17-Ketosteroids Concentrations
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概要
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Dehydroepiandrosterone acetate (DHA-Ac), 100mg/day, was administered every day for seven days to nice postmenopausal women with gynecologic malignancies. Serum levels of steroid hormones were measured before and on the 4th and 7th day after the beginning of the administration. Urinary steroid excretions were also measured in pre- and post-administration periods. Serum dehydroepiandrosterone (DHA) concentrations showed marked increase on the 4th and 7th day compared with before the administration and the mean levels reached as high as several times of the level in normal young women. Serum 11-deoxy-17-ketosteroids (11-deoxy-17-KS) levels also showed uprise trend after the administration and the values were approximately equal to or higher than the normal value in young women. In comparison of serum DHA concentrations with 11-deoxy-17-KS, in the extent of their increase in mean values, the former was exceedingly higher than the latter. The variation pattern of serum DHAsulfate (DHA-S) was similar to that of serum 11-deoxy-17-KS. The changes of urinary 17-ketosteroids (17-KS), serum cortisol, urinary 17-hydroxycorticosteroids, and serum estrogen levels were also studied. In a few cases which had abnormal high values of serum alkaline phosphatase and transaminases before the administration, there observed a decreasing trend in their values after the administration. Present study suggests that DHA might be of clinical use without accompanying serious side effects in some of the closely selected aged women and patients with gynecologic malignacies.
- 社団法人日本産科婦人科学会の論文
- 1977-08-01
著者
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YAMAMOTO Hiroshi
Department of Macromolecular Science, Graduate School of Science, Osaka University
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SHINOHARA Harumichi
Department of Anatomy, Kanazawa Medical University
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赤祖父 一知
金沢大
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Yamamoto Hiroshi
Department Of Energy Engineering And Science Nagoya University
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TOMITA Yoshimasa
Department of Neurosurgery, Juntendo University Izunagaoka Hospital
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赤祖父 一知
Department of Obstetrics and Gynecology, School of Medicine, Kanazawa University
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ARAKI Katsumi
Department of Obstetrics and Gynecology, School of Medicine, Kanazawa University
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NISHIDA Etsuro
Department of Obstetrics and Gynecology, School of Medicine, Kanazawa University
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Araki Katsumi
Department Of Obstetrics And Gynecology School Of Medicine Kanazawa University
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Araki Katsumi
Department Of Chemistry Nagaoka University Of Technology
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Nishida Etsuro
Department Of Obstetrics And Gynecology School Of Medicine Kanazawa University
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Tomita Yoshimasa
Department Of Neurosurgery Juntendo University Izunagaoka Hospital
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Tomita Yoshimasa
Department Of Obstetrics And Gynecology School Of Medicine Kanazawa University
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Shinohara Harumichi
Department Of Obstetrics And Gynecology School Of Medicine Kanazawa University
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Shinohara Harumichi
Department Of Anatomy Kanazawa Medical University
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Yamamoto Hiroshi
Departmemt Of Chemical Engineering University Of Tokyo
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Yamamoto Hiroshi
Department Of Obstetrics And Gynecology School Of Medicine Kanazawa University
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