Aminopeptidase N/CD13 Regulates the Fetal Liver Microenvironment of Hematopoiesis(Miscellaneous)

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概要

• 論文の詳細を見る

• Fetal liver (FL) hematopoiesis is thought to be important for expanding the cell number during ontogeny. In order to investigate the cellular interaction molecules among FL stromal and hematopoietic cells, we established a monoclonal antibody, Ndk-10, that reacts with FL stromal cells but not with dish non-adherent cells. When Ndk-10 was added to an FL stromal and hematopoietic cell-coculture, it inhibited the survival of c-kit^+ cells. The inhibitory activity of Ndk-10 was also observed in the fetal liver organ culture. The Ndk-10 recognized a 150 kD molecule in the adherent cells of FL and kidney, and the N-terminal amino acid sequence was identical to that of mouse aminopeptidase N/CD13. The peptidase activity of CD13 was inhibited by Ndk-10, and addition of its specific inhibitor resulted in the same inhibitory activity as Ndk-10. We propose that aminopeptidase N/CD13 is a critical molecule that regulates the survival of c-kit^+ cells in the FL microenvironment.

• 公益社団法人日本薬学会の論文
• 2004-12-01

著者

• SAKANE Naoki

  Department of Preventive Medicine, Clinical Research Institute for Endocrine and Metabolic Disease,

• Sakane N

  Kyoto Prefectural Univ. Medcine Kyoto Jpn

• YAMAMOTO Hiroshi

  Department of Macromolecular Science, Graduate School of Science, Osaka University

• Sakane N

  Kyoto Prefectural Univ. Medicine Kyoto Jpn

• Sakane Naoki

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Osaka University

• ASANO Yoko

  Department of Materials Science, Kitami Institute of Technology

• Asano Yoko

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Osaka University

• KAWAMURA Tomoko

  Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University

• TAKATANI Tomohiro

  Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University

• KOHAMA Yasuhiro

  Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University

• TSUJIKAWA Kazutake

  Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University

• Kohama Yasuhiro

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Osaka University

• Takatani Tomohiro

  Faculty Of Fisheries Nagasaki University

• Takatani Tomohiro

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Osaka University

• Tsujikawa Kazutake

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Osaka University

• Yamamoto Hiroshi

  Department Of Energy Engineering And Science Nagoya University

• Kawamura T

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Osaka University

• Yamamoto Hiroshi

  Department Of Biochemistry And Molecular Vascular Biology Kanazawa University Graduate School Of Med

• Yamamoto Hiroshi

  Pharmaceutical Res. Laboratories Ajinomoto Co. Inc.

• Yamamoto Hiroshi

  Departmemt Of Chemical Engineering University Of Tokyo

• 佐々木 典康

  Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University

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