Impact of Aging and β_3-Adrenergic-Receptor Polymorphism on Thermic and Sympathetic Responses to a High-Fat Meal

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概要

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• The present study was designed to investigate the effect of aging and β_3-adrenergic-receptor (β_3-AR) polymorphism on the thermic effect of meal (TEM) and sympathetic nervous system (SNS) response to a high-fat meal in 13 boys, 12 young men, and 11 middle-aged men. SNS activity was assessed via power spectral analysis of heart rate variability. Significantly higher very-low-frequency (VLF) components associated with thermogenic SNS activity and energy expenditure per lean body mass (EE_<LBM>) were observed in boys during the pre- and postprandial periods. There were no significant differences in VLF and EE_<LBM> in the preprandial period between the young and middle-aged men. After feeding, however, the middle-aged men showed a significantly lower TEM (% test-meal energy) and VLF compared to the young men. A multiple regression analysis revealed that age was the only significant variable contributing to both TEM and VLF, but β_3-AR polymorphism and percentage of body fat were not statistically significant. In conclusion, age likely has a greater influence on TEM and SNS thermoregulation than genetic factors such as β_3-AR polymorphism, suggesting that this age-related decrease in thermogenic response may be involved in the development of obesity among middle-aged men.

• 日本ビタミン学会の論文

著者

• SAKANE Naoki

  Department of Preventive Medicine, Clinical Research Institute for Endocrine and Metabolic Disease,

• Sakane Naoki

  美馬市国民健康保険木屋平診療所

• Sakane Naoki

  Division Of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Med

• Satoh-asahara Noriko

  Clinical Res. Inst. National Hospital Organization Kyoto Medical Center 1-1 Mukaihata-cho Fukakusa F

• Sakane Naoki

  Department Of Preventive Medicine Clinical Research Institute Center For Endocrine And Metabolic Dis

• Sakane Naoki

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Osaka University

• NAGAI Narumi

  Department of Nutritional Science, Faculty of Health and Welfare, Okayama Prefectural University

• MORITANI Toshio

  Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto Universi

• Nagai Narumi

  Department Of Food Science And Nutrition School Of Human Science And Environment University Of Hyogo

• Moritani Toshio

  Laboratory Of Applied Physiology Graduate School Of Human And Environmental Studies Kyoto University

• Moritani Toshio

  Lab. Of Applied Physiology Graduate School Of Human And Environmental Studies Kyoto Univ.

• Moritani Toshio

  Laboratory Of Applied Physiology Graduate School Of Human And Environmental Studies

• Satoh-asahara Noriko

  Division Of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Medical Center

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