The Influence of Metabolic Syndrome and Chronic Kidney Disease on Hemorheology Assessed by the Microchannel Method

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概要

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• Metabolic syndrome (MetS) and chronic kidney disease (CKD) are individual risk factors for cardiovascular disease (CVD). Abnormal hemorheology may be associated with CVD in both disorders. The present study investigated the impact of MetS and CKD on hemorheology. We studied 138 adults (women/men=63/75, mean age=52.2 years), who included 87 participants with MetS and 33 with CKD. The hemorheology was assessed by the index of ‘whole blood passage time (WBPT)’ using the Micro Channel array Flow ANalyzer (MC-FAN). The WBPT values of MetS participants were significantly higher than those of non-MetS participants (52.5±13.1 vs. 46.3±7.7 sec, p=0.03). The WBPT values of CKD participants were significantly higher than those of non- CKD (55.5±12.7 vs. 48.6±11.0 sec, p=0.003). The significant influence of MetS and CKD on WBPT was qualified by their effect modification to WBPT (p=0.04). There was a significantly greater influence of the combination of MetS and CKD on WBPT (59.9±13.4 sec) in comparison to the influence of non-MetS and CKD (46.6±3.5) or non-CKD and MetS (50.0±12.2). The influence of the combination of MetS and CKD was clearer in men, relative to women. Abnormal hemorheology as assessed using MC-FAN may be enhanced by the combination of MetS and CKD.

• 2010-09-30

著者

• Yamada Kazunori

  Diabetic Center, National Hospital Organization, Kyoto Medical Center

• Shimatsu Akira

  Division Of Clinical Research Institute Kyoto Medical Center

• Shimatsu Akira

  国立病院機構京都医療センター 展開医療研究部

• Sakane Naoki

  美馬市国民健康保険木屋平診療所

• TANIGUCHI Nobuyuki

  Department of Clinical Laboratory Medicine, Jichi Medical University

• Shimatsu Akira

  Clinical Research Institute Kyoto Medical Center National Hospital Organization

• Kotani Kazuhiko

  美馬市国民健康保険木屋平診療所

• Kotani Kazuhiko

  鳥取大学 医学部健康政策医学分野

• Shimatsu Akira

  国立病院機構京都医療センター 代謝臨床研究センター内分泌研究部

• Shimatsu Akira

  Clinical Research Center For Endocrine And Metabolic Disease Kyoto Medical Center

• Satoh-asahara Noriko

  Clinical Res. Inst. National Hospital Organization Kyoto Medical Center 1-1 Mukaihata-cho Fukakusa F

• Satoh Noriko

  国立病院機構京都医療センター 代謝臨床研究センター内分泌研究部

• Shimatsu Akira

  Division Of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Med

• Kotani Kazuhiko

  Division Of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Med

• Kotani Kazuhiko

  鳥取大学 健康政策医学分野

• Koyama Kazunori

  Clinical Research Institute National Hospital Organization Kyoto Medical Center

• Kotani Kazuhiko

  Division Of Preventive Medicine And Diabetes Education Clinical Research Institute For Endocrine And

• KOTANI Kazuhiko

  Clinical Research Institute, National Hospital Organization Kyoto Medical Center

• SATOH Noriko

  Clinical Research Institute, National Hospital Organization Kyoto Medical Center

• Satoh Noriko

  Division Of Metabolic Research Clinical Research Institute Center For Endocrine And Metabolic Diseas

• Satoh Noriko

  Clinical Research Institute For Endocrine Metabolic Diseases Kyoto Medical Center

• Yamada Kazunori

  Diabetes Center National Hospital Organization Kyoto Medical Center

• Taniguchi Nobuyuki

  Department Of Clinical Laboratory Medicine Jichi Medical University

• Taniguchi Nobuyuki

  Department Of Clinical Laboratory Medicine Jichi Medical School

• Kotani Kazuhiko

  Tottori University Faculty Of Medicine

• Kotani Kazuhiko

  Clinical Research Institute National Hospital Organization Kyoto Medical Center

• Shimatsu Akira

  Division Of Endocrinology And Metabolism Clinical Research Institute For Endocrine Metabolic Disease

• Shimatsu Akira

  Clinical Res. Inst. National Hospital Organization Kyoto Medical Center Kyoto Jpn

• Taniguchi Nobuyuki

  Department Of Clinical Laboratory Jichi Medical University

• Shimatsu Akira

  Clinical Res. Inst. Kyoto Medical Center National Hospital Organization

• TANIGUCHI NOBUYUKI

  Department of Chemical Engineering, Tokyo University of Agriculture and Technology

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