High Blood Viscosity Is Closely Associated With Cigarette Smoking and Markedly Reduced by Smoking Cessation

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概要

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• Background: Cigarette smoking is an independent risk factor for cardiovascular events such as myocardial infarction and stroke. To date, a useful and convenient method of predicting such events in smokers has not been established. The rheological properties of blood assessed by the microchannel method reflect the bloods viscosity and the state of microthrombus formation, which may predict cardiovascular thrombotic events. Methods and Results: Blood fluidity was assessed in 74 smoking patients (54 men, 20 women, mean age 57.9 years) by measuring the blood passage time (BPT) in an aliquot (100μl) of blood using the Micro Channel Array Flow Analyzer. BPT was significantly related with smoking variables such as daily consumption of tobacco (r=0.236, P=0.044), Brinkmans index (r=0.252, P=0.033), the Fagerstrom Test for Nicotine Dependence (r=0.257, P=0.029), and the score of a self-rating depression scale (r=0.236, P<0.05). Multivariate regression analysis revealed that an independent BPT determinant was daily consumption of tobacco (r=0.326, P=0.045). Furthermore, smoking cessation markedly decreased BPT from 63.0s to 49.7s (P=0.002) at 3 months after the start of therapy. Conclusions: Unfavorable blood rheology is closely associated with cigarette smoking and may reflect increased cardiovascular risk in smokers. The study results also suggest that such risk can be reduced after only 3 months of smoking cessation. (Circ J 2011; 75: 185-189)

• 社団法人　日本循環器学会の論文
• 2010-12-25

著者

• Shimatsu Akira

  Division Of Clinical Research Institute Kyoto Medical Center

• Shimatsu Akira

  国立病院機構京都医療センター 展開医療研究部

• Hidaka Kyoko

  京都大学 医学部小児科

• Wada Hiromichi

  Division Of Translational Research Kyoto Medical Center

• Wada Hiromichi

  国立病院機構京都医療センター 展開医療研究部

• Shimatsu Akira

  Clinical Research Institute Kyoto Medical Center National Hospital Organization

• Wada Hiromichi

  Division Of Translational Research Kyoto Medical Center National Hospital Organization

• Wada Hiromichi

  Department Of Cardiovascular Medicine Kyoto University Graduate School Of Medicine

• Shimatsu Akira

  国立病院機構京都医療センター 代謝臨床研究センター内分泌研究部

• Shimatsu Akira

  Clinical Research Center For Endocrine And Metabolic Disease Kyoto Medical Center

• Kitaoka Shuji

  Health Evaluation Center, National Hospital Organization Kyoto Medical Center

• Terashima Sachiko

  Health Evaluation Center, National Hospital Organization Kyoto Medical Center

• Takahashi Yuko

  Health Administration Center, Nara Women University

• Shimatsu Akira

  Division Of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Med

• Hasegawa Koji

  Division Of Translational Research Kyoto Medical Center National Hospital Organization

• Kitaoka Shuji

  Health Evaluation Center National Hospital Organization Kyoto Medical Center

• Hasegawa Koji

  Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University

• Hidaka K

  Department Of Bioscience National Cardiovascular Center Research Institute

• WADA HIROMICHI

  Clinical Research Institute for Endocrine Metabolic Disease, National Hospital Organization, Kyoto M

• SHIMADA SAYAKA

  Clinical Research Institute for Endocrine Metabolic Disease, National Hospital Organization, Kyoto M

• HASEGAWA KOJI

  Clinical Research Institute for Endocrine Metabolic Disease, National Hospital Organization, Kyoto M

• Takahashi Yuko

  Health Administration Center Nara Women University

• Yamakage Hajime

  Division Of Metabolic Research National Hospital Organization Kyoto Medical Center

• Terashima Sachiko

  Health Evaluation Center National Hospital Organization Kyoto Medical Center

• Hasegawa Koji

  国立病院機構京都医療センター 展開医療研究部

• Shimada Sayaka

  Clinical Research Institute For Endocrine Metabolic Disease National Hospital Organization Kyoto Med

• Arai Masazumi

  Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine

• Takahashi Yuko

  Health Adiministration Center Nara Women's University

• Satoh Asahara

  Clinical Research Institute Kyoto Medical Center National Hospital Organization

• YAMAKAGE Hajime

  Clinical Research Institute, Kyoto Medical Center, National Hospital Organization

• AKAO Masaharu

  Clinical Research Institute, Kyoto Medical Center, National Hospital Organization

• Akao Masaharu

  Clinical Research Institute Kyoto Medical Center National Hospital Organization

• Shimatsu Akira

  Division Of Endocrinology And Metabolism Clinical Research Institute For Endocrine Metabolic Disease

• Yamakage Hajime

  Clinical Research Institute Kyoto Medical Center National Hospital Organization

• Shimatsu Akira

  Clinical Res. Inst. National Hospital Organization Kyoto Medical Center Kyoto Jpn

• Hasegawa Koji

  Department Of Cardiovascular Medicine Kyoto University Graduate School Of Medicine

• Shimatsu Akira

  Clinical Res. Inst. Kyoto Medical Center National Hospital Organization

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