A Novel Drug Delivery System of Oral Curcumin Markedly Improves Efficacy of Treatment for Heart Failure after Myocardial Infarction in Rats

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概要

• 論文の詳細を見る

• Curcumin is an inhibitor of p300 histone acetyltransferase activity, which is associated with the deterioration of heart failure. We reported that native curcumin, at a dosage of 50 mg/kg, prevented deterioration of the systolic function in rat models of heart failure. To achieve more efficient oral pharmacological therapy against heart failure by curcumin, we have developed a novel drug delivery system (DDS) which markedly increases plasma curcumin levels. At the dosage of 0.5 mg/kg, DDS curcumin but not native curcumin restored left ventricular fractional shortening in post-myocardial infarction rats. Thus, our DDS strategy will be applicable to the clinical setting in humans.

著者

• FUJITA Masatoshi

  Human Health Sciences, Graduate School of Medicine, Kyoto University

• Wada Hiromichi

  国立病院機構京都医療センター 展開医療研究部

• Wada Hiromichi

  Division Of Engineering Graduate School Of Kansai Univ.

• Kimura Takeshi

  Department Of Cardiology Kobe City Medical Center General Hospital

• KAKEYA Hideaki

  Department of Chemistry, Keio University

• Hasegawa Koji

  Division Of Translational Research Clinical Research Institute Kyoto Medical Center National Hospita

• Sasaki Hiroki

  Theravalues Corporation

• Fukuda Hiroyuki

  Theravalues Corporation

• Hashimoto Tadashi

  Theravalues Corporation

• Katanasaka Yasufumi

  Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka

• Hashimoto Tadashi

  Theravalues Corp.

• Imaizumi Atsushi

  Theravalues Corp.

• Morimoto Tatsuya

  Division Of Molecular Medicine School Of Pharmaceutical Sciences University Of Shizuoka

• Fujita Masatoshi

  Human Health Sciences Graduate School Of Medicine Kyoto Univ.

• Shimatsu Akira

  Clinical Res. Inst. Kyoto Medical Center National Hospital Organization

• Morimoto Tatsuya

  Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka

• Sunagawa Yoichi

  Human Health Sciences, Graduate School of Medicine, Kyoto University

• Shimatsu Akira

  Clinical Research Institute, Kyoto Medical Center, National Hospital Organization

• Suzuki Hidetoshi

  Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka

• Wada Hiromichi

  Division of Translational Research, Clinical Research Institute, Kyoto Medical Center, National Hospital Organization

• Kakeya Hideaki

  Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University

• Hasegawa Koji

  Division of Translational Research, Clinical Research Institute, Kyoto Medical Center, National Hospital Organization

• KIMURA Takeshi

  Department of Applied Chemistry and Molecular Science, Faculty of Engineering, Iwate University

• Suzuki Hidetoshi

  Division of Cardiology, Heartcenter, Yokohama City Bay Red Cross Hospital

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