Small Dense LDL-Cholesterol Relative to LDL-Cholesterol is a Strong Independent Determinant of Hypoadiponectinemia in Metabolic Syndrome
スポンサーリンク
概要
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Background Small dense low-density lipoprotein (sd-LDL) is an atherogenic lipoprotein closely associated with an increased risk of cardiovascular diseases. However, a precise analysis of the actual amount of sd-LDL-cholesterol (sd-LDL-C) in patients with metabolic syndrome (MS) has not been performed. Methods and Results Among 214 patients enrolled in the present study, 101 patients (47%) met the Japanese MS criteria. The serum levels of sd-LDL-C determined with a dual detection HPLC system were higher in MS than non-MS patients, while total cholesterol and low-density lipoprotein-cholesterol (LDL-C) were similar between MS and non-MS patients. Compared with the sd-LDL-C and LDL-C level, the ratio sd-LDL-C/LDL-C was more closely correlated with various parameters associated with MS. A multivariate regression analysis revealed that the ratio sd-LDL-C/LDL-C is the strongest independent determinant of hypoadiponectinemia. Furthermore, weight reduction therapy through diet and exercise rapidly decreased LDL-C but slowly decreased sd-LDL-C. At 12 months after the therapy, weight reduction led to a significant decrease in the ratio sd-LDL-C/LDL-C in tandem with increasing adiponectin levels. Conclusions These findings demonstrate that the ratio sd-LDL-C/LDL-C is tightly connected with hypoadiponectinemia and provides a useful clinical indicator for MS. The results also suggest that the elevation of this ratio can be modulated by long-term lifestyle changes.
- 社団法人日本循環器学会の論文
- 2008-05-20
著者
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Satoh Noriko
Division of Diabetic Research, National Hospital Organization, Kyoto Medical Center
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Yamada Kazunori
Diabetic Center, National Hospital Organization, Kyoto Medical Center
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Hasegawa Koji
Division of Translational Research, National Hospital Organization, Kyoto Medical Center
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Shimatsu Akira
Division of Diabetic Research, National Hospital Organization, Kyoto Medical Center
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Shimatsu Akira
Division Of Clinical Research Institute Kyoto Medical Center
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Sakane Naoki
美馬市国民健康保険木屋平診療所
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WADA Hiromichi
Division of Translational Research, Kyoto Medical Center National Hospital Organization
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Hidaka Kyoko
京都大学 医学部小児科
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Hidaka Kyouko
Department Of Bioscience National Cardiovascular Center Research Institute
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Wada Hiromichi
Division Of Translational Research Kyoto Medical Center
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Wada Hiromichi
国立病院機構京都医療センター 展開医療研究部
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Wada Hiromichi
Division Of Engineering Graduate School Of Kansai Univ.
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Shimatsu Akira
Clinical Research Institute Kyoto Medical Center National Hospital Organization
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Ono Koh
Dep. Of Cardiovascular Medicine Graduate School Of Medicine Kyoto Univ. 54 Kawahara-cho Shogoin Saky
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Ono Koh
京都大学 医学研究科循環器内科学
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Ono Koh
Division Of Translational Research Kyoto Medical Center National Hospital Organization
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Ono Koh
National Hospital Organization And Department Of Cardiovascular Medicine Graduate School Of Medicine
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Yamakage Hajime
Division of Metabolic Research, Clinical Research Institute for Endocrine and Metabolic Diseases, Na
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Nakano Tameo
Department of Cardiovascular Medicine, National Hospital Organization, Kyoto Medical Center
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Hattori Masakazu
Division of Metabolic Research, Clinical Research Institute for Endocrine and Metabolic Diseases, Na
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Kuzuya Hideshi
Diabetes Center, National Hospital Organization, Kyoto Medical Center
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Wada Hiromichi
Division Of Translational Research Kyoto Medical Center National Hospital Organization
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Wada Hiromichi
Department Of Cardiovascular Medicine Kyoto University Graduate School Of Medicine
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Satoh-asahara Noriko
Clinical Res. Inst. National Hospital Organization Kyoto Medical Center 1-1 Mukaihata-cho Fukakusa F
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Satoh Noriko
国立病院機構京都医療センター 代謝臨床研究センター内分泌研究部
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Shimatsu Akira
Division Of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Med
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Hasegawa Koji
Division Of Translational Research Kyoto Medical Center National Hospital Organization
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Nakano Tameo
Department Of Cardiovascular Medicine National Hospital Organization Kyoto Medical Center
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Nakano Tameo
Department Of Cardiology Kyoto National Hospital
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Hasegawa Koji
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Kuzuya Hideshi
Diabetes Center National Hospital Organization Kyoto Medical Center
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Satoh Noriko
Division Of Metabolic Research Clinical Research Institute Center For Endocrine And Metabolic Diseas
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Hidaka K
Department Of Bioscience National Cardiovascular Center Research Institute
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Satoh Noriko
Clinical Research Institute For Endocrine Metabolic Diseases Kyoto Medical Center
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Yamada Kazunori
Diabetes Center National Hospital Organization Kyoto Medical Center
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Yamakage Hajime
Division Of Metabolic Research National Hospital Organization Kyoto Medical Center
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Hattori Masakazu
Division Of Metabolic Research Clinical Research Institute For Endocrine And Metabolic Diseases Nati
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Hasegawa Koji
Division Of Translational Research Clinical Research Institute Kyoto Medical Center National Hospita
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Hasegawa Koji
国立病院機構京都医療センター 展開医療研究部
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Ono Koh
Department Of The Cardiovascular Medicine Kyoto University School Hospital
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Hattori Masakazu
Division Of Diabetes Clinical Research Center National Hospital Organization Kyoto Medical Center
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Shimatsu Akira
Division Of Endocrinology And Metabolism Clinical Research Institute For Endocrine Metabolic Disease
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Ono Koh
National Hospital Organization And Department Of Cardiovascular Medicine Graduate School Of Medicine
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Ono Kou
Department Of Cardiovascular Medicine Kyoto University Hospital
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Hasegawa Koji
Department Of Cardiovascular Medicine Kyoto University Graduate School Of Medicine
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Kakeya Hideaki
Graduate School Of Medicine And Department Of System Chemotherapy And Molecular Sciences Division Of
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