The parameters related to small dense low-density lipoprotein evaluated by non-denaturing polyacrylamide gel electrophoresis method in dyslipidemic subjects : with reference to the Japanese guideline for prevention of atherosclerotic cardiovascular diseas
スポンサーリンク
概要
- 論文の詳細を見る
To prevent the development of atherosclerotic diseases, the Japanese guideline for prevention of atherosclerotic cardiovascular diseases (released from Japan Atherosclerosis Society in 2007) is clinically referred. In addition, the importance of evaluating not only the level but also the quality of low-density lipoprotein (LDL) has been advocated. Small dense LDL (sdLDL) is regarded as representation of the quality of LDL. With the LipoprintTM LDL subfraction system, utilizing non-denaturing polyacrylamide gel electrophoresis method which can evaluate several sdLDL-related parameters such as the area percentage of sdLDL, mean LDL particle size (mean LDL-PS), relative mobility in the form of the relative flotation rate (Rf), and LDL size-based phenotypic patterns. We attempted to assess the Japanese guideline for prevention of atherosclerotic cardiovascular diseases in terms of sdLDL-related parameters. We studied with 46 asymptomatic and cardiovascular disease-free dyslipidemic subjects (23 men, aged 30-58 years olds; 23 women, 31-58 years olds), who were within the primary prevention level. From the increased number of categories in the guideline, the following trends were observed; the smaller LDL-PS (p=0.002), the larger of area percentage of sdLDL (p=0.042), an increase in Rf (p=0.068), and an increase in the presence of pattern B (atherogenic phenotype) (p=0.031). These results suggested that, with the LipoprintTM system, the usage of Japanese guideline may clinically reflect well the sdLDL-related parameters, in particular the mean LDL-PS, the area percentage of sdLDL and the pattern B.
- 日本電気泳動学会の論文
- 2009-09-01
著者
-
Yamada Kazunori
Diabetic Center, National Hospital Organization, Kyoto Medical Center
-
Shimatsu Akira
Division of Diabetic Research, National Hospital Organization, Kyoto Medical Center
-
Shimatsu Akira
Division Of Clinical Research Institute Kyoto Medical Center
-
Shimatsu Akira
国立病院機構京都医療センター 展開医療研究部
-
Sakane Naoki
美馬市国民健康保険木屋平診療所
-
Sakane Naoki
Division Of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Med
-
Kotani Kazuhiko
Division of Health Adminiration and Promotion, Tottori University of Medicine
-
YAMADA Toshiyuki
Department of Clinical Laboratory Medicine, Jichi Medical University
-
Shimatsu Akira
Clinical Research Institute Kyoto Medical Center National Hospital Organization
-
Kotani Kazuhiko
美馬市国民健康保険木屋平診療所
-
Kotani Kazuhiko
鳥取大学 医学部健康政策医学分野
-
Shimatsu Akira
国立病院機構京都医療センター 代謝臨床研究センター内分泌研究部
-
Satoh-asahara Noriko
Clinical Res. Inst. National Hospital Organization Kyoto Medical Center 1-1 Mukaihata-cho Fukakusa F
-
Satoh Noriko
国立病院機構京都医療センター 代謝臨床研究センター内分泌研究部
-
Shimatsu Akira
Division Of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Med
-
Sakane Naoki
Division Of Preventive Medicine And Diabetes Education Clinical Research Institute For Endocrine And
-
Kotani Kazuhiko
Division Of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Med
-
Kotani Kazuhiko
鳥取大学 健康政策医学分野
-
Koyama Kazunori
Clinical Research Institute National Hospital Organization Kyoto Medical Center
-
Kotani Kazuhiko
Division Of Preventive Medicine And Diabetes Education Clinical Research Institute For Endocrine And
-
TSUZAKI Kokoro
Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto M
-
SANO Yoshiko
Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto M
-
MATSUOKA Yukiyo
Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto M
-
OKAZAKI Kentaro
Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto M
-
Satoh Noriko
Division Of Metabolic Research Clinical Research Institute Center For Endocrine And Metabolic Diseas
-
Satoh Noriko
Clinical Research Institute For Endocrine Metabolic Diseases Kyoto Medical Center
-
Yamada Kazunori
Diabetes Center National Hospital Organization Kyoto Medical Center
-
Yamada Toshiyuki
Department Of Biochemistry And Genome Biology Hirosaki University Graduate School Of Medicine
-
Kotani Kazuhiko
Tottori University Faculty Of Medicine
-
Kotani Kazuhiko
Division Of Clinical Laboratory Medicine Faculty Of Medicine Tottori University
-
Sano Yoshiko
Division Of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Med
-
Tsuzaki Kokoro
Division Of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Med
-
Kotani Kazuhiko
Clinical Research Institute National Hospital Organization Kyoto Medical Center
-
Matsuoka Yukiyo
Division Of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Med
-
Shimatsu Akira
Division Of Endocrinology And Metabolism Clinical Research Institute For Endocrine Metabolic Disease
-
Okazaki Kentaro
Division Of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Med
-
Yamada Toshiyuki
Department Of Applied Physics Faculty Of Engineering University Of Tokyo:(present Address) Sony Corp
-
Shimatsu Akira
Division Of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Medical Center
-
TSUZAKI KOKORO
Division of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center
-
SANO YOSHIKO
Division of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center
-
MATSUOKA YUKIYO
Division of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center
関連論文
- 8 Abnormal Activity of Hypothalamic-pituitary-adrenal Axis is Closely Associated with Cardiovascular Risk and Efficacy of Weight Reduction Therapy in Obese Patients(Is Stress a Risk of Cardiovascular Disease?,Symposium 22 (SY-22) (I),The 73rd Annual Scien
- 8 Abnormal Activity of Hypothalamic-pituitary-adrenal Axis is Closely Associated with Cardiovascular Risk and Efficacy of Weight Reduction Therapy in Obese Patients(Is Stress a Risk of Cardiovascular Disease?,Symposium 22 (SY-22) (I),The 73rd Annual Scien
- Characterization of Hair Follicles in Hirosaki Hairless Rats with Deletion of Basic Hair Keratin Genes. Enlarged Medulla, Loss of Cuticle and Long Catagen
- Adult-onset idiopathic hypogonadotropic hypogonadism presented with erectile and ejaculatory disorder
- Aldosterone Signaling Associates With p300/GATA4 Transcriptional Pathway During the Hypertrophic Response of Cardiomyocytes
- MicroRNA-1 and MicroRNA-133 in Spontaneous Myocardial Differentiation of Mouse Embryonic Stem Cells
- Left Ventricular Expression of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Failing Rat Hearts
- PJ-781 Continuous Positive Airway Pressure Therapy Reduces Serum Amyloid A/LDL Complex in Patients with Obstructive Sleep Apnea(Diabetes/Obesity/Metabolic syndrome-13, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- The Correlation between CVR-R and Carotid Atherosclerosis in Type 2 Diabetes Mellitus Patients with Diabetic Neuropathy
- Serum Levels of Free Light Chain before and after Chemotherapy in Primary Systemic AL Amyloidosis
- Comparative study of the cardio-ankle vascular index and ankle-brachial index between young Japanese and Mongolian subjects
- PJ-340 Curcumin, a Natural p300-specific Histone Acetyltransferase Inhibitor, Possesses Beneficial Effects in addition to ACE Inhibitor after Myocardial Infarction in Rats(PJ057,Translational Science (Cardiac) (H),Poster Session (Japanese),The 73rd Annual
- PE-528 Cyclin-dependent kinase-9 is Recruited on Cardiac Hypertrophic Response Gene Promoters through GATA4 in Cardiomyocytes(PE089,Cardiomyopathy/Hypertrophy (Basic) (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulat
- PE-351 Synergistic Effects of G-CSF and Erythropoietin on Left Ventricular Systolic Function in Heart Failure after Rat Myocardial Infarction(PE059,Heart Failure (Treatment) 2 (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese
- PE-297 LOX-1 is Expressed in the Adipose Tissue of High-Fat Diet-Induced Obese Mice in Close Association with MCP-1(PE050,Diabetes 1 (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Small Dense LDL-Cholesterol Relative to LDL-Cholesterol is a Strong Independent Determinant of Hypoadiponectinemia in Metabolic Syndrome
- PJ-272 Cyclin-dependent kinases-9 is required for the differentiation of mouse ES cells into cardiac myocytes.(Development and differentiation(02)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-182 A Soluble VEGF Receptor-2 is a Possible Novel Biomaker of Cardiovascular Risk in the Metabolic Syndrome(Diabetes/Obesity/Metabolic syndrome(05)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-334 Overexpression of MicroRNA-1 in Mouse Embryonic Stem Cells Represses Myocardial Differentiation(Development and differentiation(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-531 A GATA-4 Mutant Lacking p300-Induced Acetylation Suppresses Myocardial Cell Hypertrophy(Molecular biology, myocardium-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-368 Soluble FIK-1, an Endogenous Inhibitor of Vascular Endothelial Growth Factor is Increased in Serum of Smoking Men(Smoking, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-201 Serum Levels of Soluble Flk-1, an Endogenous Inhibitor of VEGF, are Decreased by Weight Reduction Therapy in Male Obese Patients(Diabetes/Obesity/Metabolic syndrome-04, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-024 Up-Regulated Expression of MicroRNA-143 in the Adipose Tissue of High-Fat Diet-Induced Obese Mice(Diabetes/Obesity (basic), The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-349 Leptin Induces Physiological and Compensated Growth of the Left Ventricles Following Myocardial Infarction in Vivo(Diabetes/Obesity/Metabolic syndrome-7 (H) PE59,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanes
- PE-245 Adipocyte-derived Serotonin Regulates Adipocyte Differentiation via an Autocrine/paracrine Mechanism(Diabetes/Obesity/Metabolic syndrome-8 (H) PE41,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation
- OJ-072 Serum Levels of Oxidized Low-density Lipoprotein Decrease during Successful Smoking Cessation(OJ12,Smoking/Alcohol/Life Style (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OJ-070 Serum Levels of Soluble VEGF Receptor-2 Decrease during Successful Smoking Cessation(OJ12,Smoking/Alcohol/Life Style (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OJ-069 Self-rating Depression Scale Score is a Strong Independent Predictor of Smoking Cessation Outcomes(OJ12,Smoking/Alcohol/Life Style (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- FRS-021 Left Ventricular Expression of Lectin-like Oxidized Low-density Lipoprotein Receptor-1 during the Development of Heart Failure(FRS5,Novel Biomarkers in Heart Failure (M),Featured Research Session (English),The 73rd Annual Scientific Meeting of The
- Myocardial Regulation of p300 and p53 by Doxorubicin Involves Ubiquitin Pathways
- OE-257 Cyclin-dependent Kinase-9 is Required for Histone Acetyltransferase Activity of p300(Cardiac hypertrophy, basic/clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- 1 A non-toxic dietary compound curcumin provides a novel heart failure therapy that targets nuclear signaling pathway in cardiac myocytes(Symposium 7 (SY-07) (M) Molecular Mechanism and Novel Therapeutic Target in Heart Failure,Special Program,The 72nd An
- PE-532 Proteomics Analysis Identifies Novel GATA-4-binding Partners Involved in Hypertrophic Responses in Cardiac Myocytes(Molecular biology, myocardium-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-435 A Natural p300-specific Histone Acetyltransferase Inhibitor, Crucumin, Prevents the Development of Hypertension-induced Heart Failure in salt-sensitive Dahl Rats(Heart failure, basic-4, The 71st Annual Scientific Meeting of the Japanese Circulation
- Long-term Follow-up of Plasma Cells in Bone Marrow and Serum Free Light Chains in Primary Systemic AL Amyloidosis
- The Influence of Metabolic Syndrome and Chronic Kidney Disease on Hemorheology Assessed by the Microchannel Method
- Toxic Thyroid Adenoma Presenting as Hypokalemic Periodic Paralysis
- Growth Hormone (GH) Effects on Central Fat Accumulation in Adult Japanese GH Deficient Patients : 6-month Fixed-dose Effects Persist during Second 6-month Individualized-dose Phase
- The Association between an Increased Level of Gamma-Glutamyl Transferase and Systolic Blood Pressure in Diabetic Subjects
- Mood Change Tendency and Fasting Plasma Glucose Levels in a Japanese Female Population
- Measurement of Cystatin C in Cerebrospinal Fluid
- The parameters related to small dense low-density lipoprotein evaluated by non-denaturing polyacrylamide gel electrophoresis method in dyslipidemic subjects : with reference to the Japanese guideline for prevention of atherosclerotic cardiovascular diseas
- S447X Polymorphism in the Lipoprotein Lipase Gene and the Adiponectin Level in the General Population : Results from the Mima Study
- The Status of Internet Access in Adult Patients with Atopic Dermatitis in Japan
- Insufficient Smoking Restrictions in Restaurants Around Junior High Schools in Japan
- A Survey of Restaurant Smoking Restrictions in a Japanese City
- Localization of injected anti-serum amyloid A antibody to the lesions in murine reactive amyloidosis
- OE-134 Regulated Expression of MicroRNAs During Differentiation of Mouse Embryonic Stem Cells into Cardiac Myocytes(Development and differentiation-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Highly purified eicosapentaenoic acid reduces cardio-ankle vascular index in association with decreased serum amyloid A-LDL in metabolic syndrome
- Evaluation of the Cardio-Ankle Vascular Index, a New Indicator of Arterial Stiffness Independent of Blood Pressure, in Obesity and Metabolic Syndrome
- Lack of Association of the Trp64Arg Polymorphism of β_3-Adrenergic Receptor Gene with Energy Expenditure in Response to Caffeine Among Young Healthy Women
- Up-regulation of Muscle Uncoupling Protein 3 Gene Expression by Calcium Channel Blocker, Benidipine Hydrochloride in Rats
- Effects of risedronate or alfacalcidol on bone mineral density, bone turnover, back pain, and fractures in Japanese men with primary osteoporosis : results of a two-year strict observational study
- Three-month changes in bone turnover markers and bone mineral density response to raloxifene in Japanese postmenopausal women with osteoporosis
- Clinical Significance of 1-year Treatment with Raloxifene on Bone and Lipid Metabolism in Japanese Postmenopausal Women with Osteoporosis
- Unfavorable Blood Rheology is Closely Associated with Arterial Stiffness in Obese Patients
- Pituitary and Stalk Lesions (Infundibulo-hypophysitis) Associated with Immunoglobulin G4-related Systemic Disease : an Emerging Clinical Entity
- Rebound Hypersecretion of GH Following Octreotide Withdrawal due to Liver Dysfunction in an Acromegalic Patient
- Increased Bone Turnover in Patients with Hypercholesterolemia
- Efficacy of Combined Treatment with Raloxifene and Alfacalcidol on Bone Density and Biochemical Markers of Bone Turnover in Postmenopausal Osteoporosis
- Association between Baseline Values of Bone Turnover Markers and Bone Mineral Density and Their Response to Raloxifene Treatment in Japanese Postmenopausal Women with Osteoporosis
- FRS-062 Decreased in Adiponectin is an Independent Determinant of Small Dense LDL Relative to LDL-Cholestererol in Hypertensive Patients with Metabolic Syndrome(Diabetes/Obesity (clinical), The 71st Annual Scientific Meeting of the Japanese Circulation So
- Glutathione S-transferase A4 is a positive marker for rat hepatic foci induced by clofibrate and genotoxic carcinogens
- Histone acetylation and steroid receptor coactivator expression during clofibrate-induced rat hepatocarcinogenesis
- Development of glutathione S-transferase-P-negative foci accompanying nuclear factor-erythroid 2-related factor 2 expression during early stage of rat hepatocarcinogenesis
- OE-196 Identification of Signaling Pathways that Mediate Myocardial GLUT4 Translocation using a Novel Lenti Viral-mediated GLUT4 Reporter Gene(Metabolism/Biochemistry/Energetics-1 (H) OE33,Oral Presentation (English),The 70th Anniversary Annual Scientific
- OE-049 Cyclin-dependent Kinase-9 is a Novel Component of p300/GATA-4 Complex Required for Hypertrophic Responses in Cardiac Myocytes(Cardiac hypertrophy, basic/clinical-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Functional roles of Fli-1, a member of the Ets family of transcription factors, in human breast malignancy
- The Sleep Status of Subjects with Hypertensive Levels of Diastolic Blood Pressure
- Serum Amyloid A Protein and Carotid Intima-Media Thickness in Healthy Young Subjects
- Increased Red Blood Cells in Patients with Metabolic Syndrome
- Impact of Aging and β_3-Adrenergic-Receptor Polymorphism on Thermic and Sympathetic Responses to a High-Fat Meal
- Metabolic Responses to High-Fat or Low-Fat Meals and Association with Sympathetic Nervous System Activity in Healthy Young Men
- Relationship Between Abdominal Visceral Fat and Lacunar Infarcts in Japanese Men
- High reactivity of monoclonal antibody (TO73) with human malignant tumor cell line
- Reactivity of antibody YU-311 in formalin-fixed, paraffin-embedded specimens of normal organs, non-hematopoietic tumors, and mast cell tumors
- A Young Female with Marked Hyperlipoprotein(a)emia Associated with Nephrotic Syndrome and Stroke
- Asymptomatic Fascioliasis
- Causes of Chronic Retention of Urine in the Primary Care Setting
- Epidemiological study of gastroenteropancreatic neuroendocrine tumors in Japan
- Lifestyle-related Factors Which Affect Blood Pressure Components in Outpatients with Hypertensive Status : A Hospital-based Study
- Pharmacology in Health Foods:Merits and Demerits of Food With Health Claims for the Prevention of Metabolic Syndrome
- Somatoform pain disorder in a case of Klinefelter's syndrome with multiply operated lower back
- Low-Calorie Diet-Induced Reduction in Serum HDL Cholesterol Is Ameliorated in Obese Women with the -3826 G Allele in the Uncoupling Protein-1 Gene
- PE-242 Simvastatin Improves Impairment of Left Ventricular Diastolic Filling in a Rat Model of Type II Diabetes with Obesity(Diabetes/Obesity/Metabolic syndrome-8 (H) PE41,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japa
- OJ-048 A Soluble Flk-1, an Endogenous Inhibitor of Vascular Endothelial Growth Factor, is Increased in Serum of Patients with Metabolic Syndrome(Diabetes/Obesity/Metabolic syndrome-3 (H) OJ8,Oral Presentation (Japanese),The 70th Anniversary Annual Scienti
- Epigallocatechin-3-gallate, a Major Polyphenolic Constituent of Green Tea, Induces Apoptosis in 3T3-L1 Preadipocytes After Induction of Differentiation(Diabetes/Obesity 3 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- The Improvement of Sweet Taste Sensitivity with Decrease in Serum Leptin Levels During Weight Loss in Obese Females
- A Case of Subclinical Hypothyroidism Developing Marked Pleural Effusions and Peripheral Edema with Elevated Vascular Endothelial Growth Factor
- High Blood Viscosity Is Closely Associated With Cigarette Smoking and Markedly Reduced by Smoking Cessation
- Both acute phase and constitutive serum amyloid A are present in atherosclerotic lesions
- Leptin Activates JAK2/STAT3 Pathways And Induces Elongation in Cardiac Myocytes(Cardiac Hypertrophy 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Identification of Genes Required for Adipocyte Differentiation by Retrovirus Insertion-mediated Random Mutagenesis(Development and Differentiation 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Enkephalin is Expressed in Visceral Adipose Tissue And Required for Differentiation into Mature Adipocytes(Diabetes/Obesity 4 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- A Natural p300-Specific Histone Acetyltransferase Inhibitor, Curcumin, in Addition to Angiotensin-Converting Enzyme Inhibitor, Exerts Beneficial Effects on Left Ventricular Systolic Function After Myocardial Infarction in Rats
- Sweet taste and (AAT) 12 repeat in the cannabinoid receptor gene in obese females
- Lipid Profiles in the Untreated Patients with Hashimoto Thyroiditis and the Effects of Thyroxine Treatment on Subclinical Hypothyroidism with Hashimoto Thyroiditis
- 自治医科大学における生理機能検査の学生教育 : 実習を取り入れた超音波診断学
- Short-term Effects of Pitavastatin on Biochemical Markers of Bone Turnover in Patients with Hypercholesterolemia
- Efficacy of Risedronate in Japanese Male Patients with Primary Osteoporosis