Metabolic Responses to High-Fat or Low-Fat Meals and Association with Sympathetic Nervous System Activity in Healthy Young Men

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概要

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• The present study was designed to investigate the metabolic and sympathetic responses to a high-fat meal in humans. Fourteen young men (age : 23.6±0.5y, BMI : 21.3±0.4kg/m^2) were examined for energy expenditure and fat oxidation measured by indirect calorimetry for 3.5h after a high-fat (70% energy from fat) or an isoenergetic low-fat (20% energy from fat) meal served in random order. The sympathetic nervous system (SNS) activity was assessed using power spectral analysis of heart rate variability (HRV). After the high-fat meal, increases in thermoregulatory SNS activity (very low-frequency component of HRV, 0.007-0.035Hz, 577.4±45.9vs. 432.0±49.3ms^2, p<0.05) and fat oxidation (21.0±5.3 vs. 13.3±4.3g, p<0.001) were greater than those after the low-fat meal. However, thermic effects of the meal (TEM) were lower after the high-fat meal than after the low-fat meal (27.5±11.2 vs. 36.1±10.9kcal, p<0.05). In conclusion, the high-fat meal can stimulate thermoregulatory SNS and lipolysis, but resulted in lower TEM, suggesting that a high proportion of dietary fat intake, even with a normal daily range of calories, may be a potent risk factor for further weight gain.

• 日本ビタミン学会の論文

著者

• SAKANE Naoki

  Department of Preventive Medicine, Clinical Research Institute for Endocrine and Metabolic Disease,

• Sakane Naoki

  美馬市国民健康保険木屋平診療所

• Sakane Naoki

  Division Of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Med

• Satoh-asahara Noriko

  Clinical Res. Inst. National Hospital Organization Kyoto Medical Center 1-1 Mukaihata-cho Fukakusa F

• Sakane Naoki

  Department Of Preventive Medicine Clinical Research Institute Center For Endocrine And Metabolic Dis

• Sakane Naoki

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Osaka University

• MORITANI Toshio

  Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto Universi

• NAGAI Narumi

  Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto Universi

• Nagai Narumi

  Department Of Food Science And Nutrition School Of Human Science And Environment University Of Hyogo

• Moritani Toshio

  Laboratory Of Applied Physiology Graduate School Of Human And Environmental Studies Kyoto University

• Moritani Toshio

  Lab. Of Applied Physiology Graduate School Of Human And Environmental Studies Kyoto Univ.

• Moritani Toshio

  Laboratory Of Applied Physiology Graduate School Of Human And Environmental Studies

• Satoh-asahara Noriko

  Division Of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Medical Center

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