Biomarkers of Aging in Women and the Rate of Longitudinal Changes
スポンサーリンク
概要
- 論文の詳細を見る
The purposes of this study were 1) to estimate biological age score (BAS) in Japanese healthy women based on the 4-7 years longitudinal data for physiological, hematological and biochemical examinations and 2) to examine the rate of aging changes in adult women based on the estimated BAS. The samples consisted of cross-sectional (n=981) and longitudinal (n=110) groups. Out of 31 variables examined, five variables (forced expiratory volume in 1.0 s, systolic blood pressure, mean corpuscular hemoglobin, glucose, albumin/globulin ratio) that met the following criteria: 1) significant cross-sectional correlation with age; 2) significant longitudinal change in the same direction as the cross-sectional correlation; and 3) assessment of redundancy, were selected as candidate biomarkers of aging. This variable set was then submitted into a principal component analysis, and the first principal component obtained from this analysis was used as an equation for assessing one's BAS. Individual BAS showed a high longitudinal stability of age-related changes, suggesting high predictive validity of our newly developed aging measurement equation. However, changes in the aging rate based on the estimated BAS were not constant. The mean slopes of the regression lines of BAS for the three age groups (age<45, 45⪈age<65 yrs, 65⪈age) were 0.095, 0.065, 0.138, respectively. One-way analysis of variance detected a significant difference (F=5.14, p<0.01) among the three age groups. These results suggest that the rate of aging in adult women is relatively slower until 65 years of age, but after 65, the rate of aging shows a rapid increase. We concluded that the longitudinal method used for selection of variables to compute the BAS was useful and theoretically valid compared to those obtained from cross-sectional data analysis.
- 日本生理人類学会の論文
著者
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Moritani Toshio
Laboratory Of Applied Physiology Graduate School Of Human And Environmental Studies Kyoto University
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Moritani T
Laboratory Of Applied Physiology Graduate School Of Human And Environmental Studies Kyoto University
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Ueno Linda
Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto Universi
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Yamashita Yoshinori
Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto Universi
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Nakamura Eitaro
Department of Life Sciences, Faculty of Integrated Human Studies, Kyoto University
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Moritani Toshio
Laboratory Of Applied Physiology Graduate School Of Human And Environmental Studies
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Nakamura Eitaro
Department Of Life Sciences Faculty Of Integrated Human Studies Kyoto University
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Yamashita Yoshinori
Laboratory Of Applied Physiology Graduate School Of Human And Environmental Studies Kyoto University
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