Effect of the Combination of Ginseng, Oriental Bezoar and Glycyrrhiza on Autonomic Nervous Activity as Evaluated by Power Spectral Analysis of HRV and Cardiac Depolarization-Repolarization Process
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概要
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Background: Ginseng, oriental bezoar and glycyrrhiza are the most wide-spread herbs often used in Kampo. These three herbs have been used for a Kampo for a thousand years and a number of pharmacological and clinical studies have reported about their effects. However, it has not been previously described how the combination of these most commonly used herbs affects the autonomic nervous system (ANS). Objective: This is a randomized, double-blind, placebo-controlled experiment to examine the acute effects of Kampo on autonomic nervous activity by using power spectral analysis of heart rate variability (HRV) and cardiac depolarization-repolarization time intervals in humans. Design: Ten healthy men volunteered to participate in this study. The Kampo at a dose of two capsules contained the following ingredients: powdered ginseng 250mg, powdered oriental bezoar 50mg, and powdered glycyrrhiza 50mg. The placebo capsules contained corn starch. A CM5 lead ECG was recorded before, and 30min and 60min after the oral administration of Kampo or a placebo on different days. Results: HF power (high frequency component in the HRV) was significantly increased and HR (heart rate) was significantly decreased after taking Kampo at 60min (p<0.05) compared with the placebo. TP (total power) and LF power (low frequency component in the HRV) did not change significantly between the Kampo and placebo, and there were also no statistically significant differences in heart-rate-corrected ECG QT interval (QTc) or recovery time (RTc) between the Kampo and placebo. However, we observed that there was a tendency of decreased QTc interval and RTc after taking Kampo at 60min compared with response of the placebo (p<0.1). Conclusions: These results indicated that the Kampo mainly potentiated parasympathetic nervous activity and may be useful for cardiovascular health.
- 日本ビタミン学会の論文
著者
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ZHENG Aisong
Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto Universi
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Moritani Toshio
Laboratory Of Applied Physiology Graduate School Of Human And Environmental Studies
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Zheng Aisong
Laboratory Of Applied Physiology Graduate School Of Human And Environmental Studies Kyoto University
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