The Effect of L-citrulline Ingestion on ECG QT Interval and Autonomic Nervous System Activity

スポンサーリンク

概要

• 論文の詳細を見る

• The purpose of this study was to investigate the effect of L-citrulline ingestion on ECG QT interval. To accomplish this purpose, nine male subjects (age: 23.4±0.5 years, weight: 57.7±5.6 kg) participated, who had no history of cardiovascular or respiratory function disorders. Each subject performed two tests (L-citrulline and placebo ingestion) on a separate day. ECG was taken before, and 60 min and 90 min after L-citrulline ingestion. The heart-rate-corrected QT interval (QTc) decreased significantly 60 min (p=0.0004) and 90 min (p=0.011) after L-citrulline ingestion. However, there were no significant changes after placebo ingestion. In addition, the interaction between L-citrulline ingestion and placebo was significant (two-way ANOVA: interaction, p=0.010). Our major finding was that L-citrulline ingestion decreases the QT interval in healthy subjects. This result suggests that transient L-citrulline ingestion may shorten the time required to complete myocardial depolarization and repolarization.

• 2011-03-31

著者

• Morishita Koji

  Healthcare Product Development Center Kyowa Hakko Bio Co. Ltd.

• Kimura Tetsuya

  Laboratory of Applied Microbiology, Faculty of Bioresources, Mie University

• Moritani Toshio

  Laboratory Of Applied Physiology Graduate School Of Human And Environmental Studies Kyoto University

• Fujibayashi Mami

  Laboratory Of Applied Physiology Graduate School Of Human And Environmental Studies Kyoto University

• Morita Masahiko

  Healthcare Products Development Center, KYOWA HAKKO BIO CO., LTD.

• Kameda Naoko

  Department Of Food And Nutrition Science Sagami Women's Junior College

• Morita Masahiko

  Healthcare Products Development Center Kyowa Hakko Bio Co. Ltd.

• OKIGAWA Tatsuya

  Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto Universi

• ASADA Tomoko

  Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto Universi

• KINOSHITA Ryohei

  Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto Universi

• BABA Sadayuki

  Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto Universi

• Moritani Toshio

  Laboratory Of Applied Physiology Graduate School Of Human And Environmental Studies

• Asada Tomoko

  Laboratory Of Applied Physiology Graduate School Of Human And Environmental Studies Kyoto University

• Baba Sadayuki

  Laboratory Of Applied Physiology Graduate School Of Human And Environmental Studies Kyoto University

• Okigawa Tatsuya

  Laboratory Of Applied Physiology Graduate School Of Human And Environmental Studies Kyoto University

• Kinoshita Ryohei

  Laboratory Of Applied Physiology Graduate School Of Human And Environmental Studies Kyoto University

• Kimura Tetsuya

  Laboratory Of Applied Physiology Graduate School Of Human And Environmental Studies Kyoto University

• Morita Masahiko

  Healthcare Products Dev. Center Kyowa Hakko Bio Co. Ltd.

• Morishita Koji

  Healthcare Products Development Center, KYOWA HAKKO BIO CO., LTD.

関連論文

• Emulsification of Coenzyme Q_ Using Gum Arabic Increases Bioavailability in Rats and Human and Improves Food-Processing Suitability
• Breeding of Yukirasha : Common Scab-Resistant Potato Variety for Table Stock
• Effect of Low Dose Vitamin K2 (MK-4) Supplementation on Bio-Indices in Postmenopausal Japanese Women
• Effects of St John's Wort extracts on corticosterone levels dysregulated by social isolation stress
• Impact of Aging and β_3-Adrenergic-Receptor Polymorphism on Thermic and Sympathetic Responses to a High-Fat Meal
• Metabolic Responses to High-Fat or Low-Fat Meals and Association with Sympathetic Nervous System Activity in Healthy Young Men
• 3D11-3 In vitro growth and hydrolysis of cellulose and xylan by Emericella nidulans Rs1 in the presence of fermentation inhibitors
• Human Skeletal Muscle Contractile Properties Assessed by Mechanomyogram during Experimentally-induced Hypothermia and Muscle Fatigue
• Electrical stimulation enhances energy consumption, glycogen utilization and whole body glucose uptake in humans
• Immunological Studies on ATPases in Mung Bean Hypocotyl Plasma Membrane : Proposal of the Presence of Two Molecular Species of ATPase
• The Presequence of a Precursor to the (δ-Subunit of Sweet Poteto Mitochondrial F_1 ATPase is not Sufficient for the Transport of β-Glucuronidase (GUS) into Mitochondria of Tobacco, Rice and Yeast Cells
• Partial Purification and Characterization of An ATPase in Mung Bean Hypocotyl Plasma Membrane : Suggestion for A New Type of Higher Plant Plasma Membrane ATPase
• Effects of Capsaicin-containing Yellow Curry Sauce on Sympathetic Nervous System Activity and Diet-induced Thermogenesis in Lean and Obese Young Women
• NEURAL NETWORKS CONTROLLING SQUID CHROMATOPHORE ORGANS IN LOCAL SKIN AREA(Physiology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
• Metalloregulatory Properties of the ArsR and ArsD Repressors of Acidiphilium multivorum AIU 301
• Low-Calorie Diet-Induced Reduction in Serum HDL Cholesterol Is Ameliorated in Obese Women with the -3826 G Allele in the Uncoupling Protein-1 Gene
• Capsaicin Increases Modulation of Sympathetic Nerve Activity in Rats : Measurement Using Power Spectral Analysis of Heart Rate Fluctuations
• Molecular Cloning of Xylanase Gene xynG1 from Aspergillus oryzae KBN 616, a Shoyu Koji Mold, and Analysis of Its Expression
• Alterations of Autonomic Nervous Activity and Energy Metabolism by Capsaicin Ingestion during Aerobic Exercise in Healthy Men
• The Combined Effects of Capsaicin, Green Tea Extract and Chicken Essence Tablets on Human Autonomic Nervous System Activity
• Clinical Study on the Combined Effect of Capsaicin, Green Tea Extract and Essence of Chicken on Body Fat Content in Human Subjects
• Effects of Chicken Essence Tablets on Resting Metabolic Rate(Food & Nutrition Science)
• Alpha-adrenoceptor gene variants and autonomic nervous system function in a young healthy Japanese population
• Validity of Critical Velocity as Swimming Fatigue Threshold in the Competitive Swimmer
• The Effect of L-citrulline Ingestion on ECG QT Interval and Autonomic Nervous System Activity
• Neuroprotective Effects of Citidine-5-diphosphocholine on Impaired Spatial Memory in a Rat Model of Cerebrovascular Dementia
• Effect of the Combination of Ginseng, Oriental Bezoar and Glycyrrhiza on Autonomic Nervous Activity and Immune System under Mental Arithmetic Stress
• Citidine-5-diphosphocholine Ameliorates the Impairment of Spatial Memory Induced by Scopolamine
• Effect of aldehyde dehydrogenase-2 genotype on cardiac autonomic nervous responses to moderate alcohol ingestion
• Biomarkers of Aging in Women and the Rate of Longitudinal Changes
• Influence of CoQ10 on Autonomic Nervous Activity and Energy Metabolism during Exercise in Healthy Subjects
• 043G20 ELECTROMYOGRAPHIC EVIDENCE OF SELECTIVE FATIGUE DURING ECCENTRIC PHASE OF STRETCH-SHORTENING CYCLES IN MAN
• Effect of the Combination of Ginseng, Oriental Bezoar and Glycyrrhiza on Autonomic Nervous Activity as Evaluated by Power Spectral Analysis of HRV and Cardiac Depolarization-Repolarization Process
• Neuroprotective Effects of Citidine-5-diphosphocholine on Impaired Spatial Memory in a Rat Model of Cerebrovascular Dementia
• Purification of the Ruminococcus albus Endoglucanase IV Using a Cellulose-Binding Domain as an Affinity Tag
• Increasing Effect of an Oral Intake of L-Hydroxyproline on the Soluble Collagen Content of Skin and Collagen Fragments in Rat Serum
• Dietary Ornithine Affects the Tissue Protein Synthesis Rate in Young Rats
• Effect of Dietary Ornithine on the Brain Protein Synthesis Rate in Hypophysectomized Aged Rats

もっと見る 閉じる

スポンサーリンク