Neuroprotective Effects of Citidine-5-diphosphocholine on Impaired Spatial Memory in a Rat Model of Cerebrovascular Dementia
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概要
- 論文の詳細を見る
Citidine-5-diphosphocholine or citicoline (CDP-choline) is used as a neuroprotective and memory-enhancing drug in cerebral stroke, Alzheimer’s disease, and other neurovascular diseases. Non-clinical studies have demonstrated the neuroprotective effects of CDP-choline in ischemic animal models. However, the relationship between the neuroprotective effect and the memory enhancing effect of CDP-choline is still unknown. No studies have demonstrated the ameliorative effect on impaired spatial memory and the suppressive effect on neuronal cell death of CDP-choline in the same model. In this study, we examined the effect of CDP-choline on impaired spatial memory and hippocampal CA1 neuronal death in rats subjected to repeated cerebral ischemia, and we compared the mechanism of CDP-choline to that of donepezil. Seven days post administration of CDP-choline (100, 300, 1000 mg/kg per day, p.o.) or donepezil increased correct choices and reduced error choices in an eight-arm radial maze task in a dose-dependent manner. Neuronal cell death of caspase-3 protein–positive neurons in the hippocampus were reduced by repeated administration of CDP-choline at the highest dose. These results suggest that CDP-choline has ameliorative effects on the impairment of spatial memory via hippocampal neuronal cell death in a rat model of cerebral ischemia.
著者
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Morishita Koji
Healthcare Product Development Center Kyowa Hakko Bio Co. Ltd.
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Uchida Kanako
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Iwasaki Katsunori
Department Of Mathematical Sciences The University Of Tokyo
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Nogami Ai
Department Of Neuropharmacology Fukuoka University
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Kubota Kaori
Department Of Astronomy Kyoto University
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Takasaki Kotaro
Department Of Neuropharmacology Fukuoka University
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YAMAGUCHI KAZUKO
Department of Pediatrics, Nippon Medical School
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Mishima Kenichi
Department Of Chemical Engineering Faculty Of Engineering Fukuoka University
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Fujiwara Michihiro
Department Of Neuroparmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Katsurabayashi Shutaro
Department of Neuropharmacology, Faculty of Pharmaceutical Science, Fukuoka University
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Morita Masahiko
Healthcare Products Development Center Kyowa Hakko Bio Co. Ltd.
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Nakamura Kazuya
Department Of Mechanical And Systems Engineering Doshisha University
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Fujikawa Risako
Department of Neuropharmacology, Faculty of Pharmaceutical Science, Fukuoka University, Japan
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Kawasaki Chihiro
Department of Neuropharmacology, Faculty of Pharmaceutical Science, Fukuoka University, Japan
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Morita Masahiko
Healthcare Products Dev. Center Kyowa Hakko Bio Co. Ltd.
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Yamaguchi Kazuko
Department Of Neuropharmacology Faculty Of Pharmaceutical Science Fukuoka University
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Katsurabayashi Shutaro
Department Of Neuropharmacology Faculty Of Pharmaceutical Science Fukuoka University
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Takasaki Kotaro
Department Of Neuropharmacology Faculty Of Pharmaceutical Science Fukuoka University
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Nogami Ai
Department Of Neuropharmacology Faculty Of Pharmaceutical Science Fukuoka University
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Uchida Kanako
Department Of Neuropharmacology Faculty Of Pharmaceutical Science Fukuoka University
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Kawasaki Chihiro
Department Of Neuropharmacology Faculty Of Pharmaceutical Science Fukuoka University
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Fujikawa Risako
Department Of Neuropharmacology Faculty Of Pharmaceutical Science Fukuoka University
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