Effect of Low Dose Vitamin K2 (MK-4) Supplementation on Bio-Indices in Postmenopausal Japanese Women

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概要

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• It has been reported that treatment with a pharmacological dose (45mg/d) of menaquinone-4(MK-4) prevents bone loss in postmenopausal women. However, it is not known whether supplementation with low dose MK-4 has beneficial effects on bone metabolism in healthy women. The aim of this study is to examine the effects of the supplementation of 1.5mg/d MK-4 for 4wk on bone and lipid metabolism in healthy postmenopausal Japanese women. The study was performed as a randomized double blind placebo-controlled trial. The participants aged 53-65y were randomly assigned to 2 groups and supplemented with 1.5mg/d of MK-4 or a placebo for 4wk (n=20 for each group). The most marked effects of MK-4 intake were observed on serum osteocalcin (OC) concentrations. Serum undercarboxylated OC (ucOC) concentration decreased, and the γ-carboxylated OC (GlaOC) and GlaOC/GlaOC+ucOC ratio that indicates the degree of OC γ-carboxylation increased significantly at 2 and 4wk compared with that at baseline in the MK-4 group. The serum ucOC and GlaOC concentrations in the MK-4 group were significantly different from those in the placebo group at 2wk. These results suggest that supplementation with 1.5mg/d MK-4 accelerated the degree of OC γ-carboxylation. The concentrations of serum lipids and other indices were not different between the groups at either intervention period. Thus, the additional intake of MK-4 might be beneficial in the maintenance of bone health in postmenopausal Japanese women.

• 日本ビタミン学会の論文

著者

• MORISHITA Koji

  Healthcare Product Development Center, Kyowa Hakko Bio Co., Ltd.

• Morishita Koji

  Healthcare Product Development Center Kyowa Hakko Bio Co. Ltd.

• SASAKI Satoshi

  Nutritional Epidemiology Program, National Institute of Health and Nutrition

• Morishita Koji

  Healthcare Products Development Center Kyowa Hakko Bio Co. Ltd.

• KOITAYA Noriko

  Nutritional Epidemiology Program, National Institute of Health and Nutrition

• EZAKI Junko

  Nutritional Epidemiology Program, National Institute of Health and Nutrition

• NISHIMUTA Mamoru

  Nutritional Epidemiology Program, National Institute of Health and Nutrition

• YAMAUCHI Jun

  Nutritional Epidemiology Program, National Institute of Health and Nutrition

• HASHIZUME Erika

  Healthcare Products Development Center, Kyowa Hakko Bio Co., Ltd.

• MIYACHI Motohiko

  Health Promotion Program, National Institute of Health and Nutrition

• ISHIMI Yoshiko

  Nutritional Epidemiology Program, National Institute of Health and Nutrition

• Ezaki Junko

  Nutritional Epidemiology Program National Institute Of Health And Nutrition

• Ezaki Junko

  Division Of Applied Food Research National Institute Of Health And Nutrition

• Yamauchi Jun

  Nutritional Epidemiology Program National Institute Of Health And Nutrition

• Koitaya Noriko

  Nutritional Epidemiology Program National Institute Of Health And Nutrition

• Ishimi Yoshiko

  Nutritional Epidemiology Program Bio-index Project National Institute Of Health And Nutrition

• Yamauchi Jun

  Nutritional Epidemiology Program Bio-index Project National Institute Of Health And Nutrition

• Hashizume Erika

  Healthcare Products Development Center Kyowa Hakko Bio Co. Ltd.

• Nishimuta Mamoru

  Nutritional Epidemiology Program National Institute Of Health And Nutrition

• Miyachi Motohiko

  Health Promotion Program National Institute Of Health And Nutrition

• Miyachi Motohiko

  Health Promotion Program National Inst. Of Health And Nutrition

• Sasaki Satoshi

  Nutritional Epidemiology Program National Institute Of Health And Nutrition

• Nishimuta Mamoru

  Nutritional Epidemiology Program National Inst. Of Health And Nutrition

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