Citidine-5-diphosphocholine Ameliorates the Impairment of Spatial Memory Induced by Scopolamine
スポンサーリンク
概要
- 論文の詳細を見る
The memory enhancing effects of orally administered citidine-5-diphosphocholine or citicoline (CDP-choline) on memory impairment without neuronal cell death are still unknown. We investigated the effects of CDP-choline on memory disturbance induced by scopolamine using an eight-armed radial maze task. Orally repeated administration of CDP-choline or histidine significantly restored the errors impaired by scopolamine. CDP-choline may increase hippocampal and neocortical acetylcholine levels. These results suggest that CDP-choline has ameliorative effects on the impairment of spatial memory induced not only by neuronal cell death but also by impaired cholinergic signal.
- 公益社団法人 日本薬学会の論文
著者
-
Morishita Koji
Healthcare Product Development Center Kyowa Hakko Bio Co. Ltd.
-
Motohashi Kyouko
Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
-
Mishima Kenichi
Dep. Of Neuropharmacology Fac. Of Pharmaceutical Sciences Fukuoka Univ.
-
Iwasaki Katsunori
Department Of Mathematical Sciences The University Of Tokyo
-
Nogami Ai
Department Of Neuropharmacology Fukuoka University
-
Kubota Kaori
Department Of Astronomy Kyoto University
-
Takasaki Kotaro
Department Of Neuropharmacology Fukuoka University
-
Mishima Kenichi
Department Of Chemical Engineering Faculty Of Engineering Fukuoka University
-
Sakamoto Yuya
Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
-
Fujiwara Michihiro
Department Of Neuroparmacology Faculty Of Pharmaceutical Sciences Fukuoka University
-
Morita Masahiko
Healthcare Products Development Center, KYOWA HAKKO BIO CO., LTD.
-
Nagao Masaki
Department of Neuropharmacology, Faculty of Pharmaceutical Science, Fukuoka University
-
Katsurabayashi Shutaro
Department of Neuropharmacology, Faculty of Pharmaceutical Science, Fukuoka University
-
Morita Masahiko
Healthcare Products Development Center Kyowa Hakko Bio Co. Ltd.
-
Matsushita Michihiko
Department Of Psychiatry Fukuoka University School Of Medicine
-
Morita Masahiko
Healthcare Products Dev. Center Kyowa Hakko Bio Co. Ltd.
-
Sakamoto Yuya
Department Of Neuropharmacology Faculty Of Pharmaceutical Science Fukuoka University
-
Katsurabayashi Shutaro
Department Of Neuropharmacology Faculty Of Pharmaceutical Science Fukuoka University
-
Takasaki Kotaro
Department Of Neuropharmacology Faculty Of Pharmaceutical Science Fukuoka University
-
Nogami Ai
Department Of Neuropharmacology Faculty Of Pharmaceutical Science Fukuoka University
-
Matsushita Michihiko
Healthcare Products Development Center Kyowa Hakko Bio Co. Ltd.
-
Kubota Kaori
Department of Neuropharmacology, Faculty of Pharmaceutical Science, Fukuoka University
-
Sakamoto Yuya
Department of Neuropharmacology, Faculty of Pharmaceutical Science, Fukuoka University
-
Takasaki Kotaro
Department of Neuropharmacology, Faculty of Pharmaceutical Science, Fukuoka University
-
Fujiwara Michihiro
Department of Neuropharmacology, Faculty of Pharmaceutical Science, Fukuoka University
-
Iwasaki Katsunori
Department of Neuropharmacology, Faculty of Pharmaceutical Science, Fukuoka University
-
Nagao Masaki
Department of Applied Chemistry, Faculty of Science and Technology, Keio University
関連論文
- Emulsification of Coenzyme Q_ Using Gum Arabic Increases Bioavailability in Rats and Human and Improves Food-Processing Suitability
- Neuroprotective Effect of Repeated Treatment with Hericium erinaceum in Mice Subjected to Middle Cerebral Artery Occlusion
- fNIRSによる言語流暢課題遂行時の前頭前野における脳血液量の測定
- 精神機能におけるバソプレシン受容体の役割
- P1-475 精神科外来におけるうつ病患者の唾液中ストレス関連物質の測定(一般演題 ポスター発表,薬物療法(精神科領域),医療薬学の創る未来 科学と臨床の融合)
- No Evidence for Variability of Intervening Absorption Lines toward GRB 060206 : Implications for the Mg II Incidence Problem
- 量子化学計算を利用した高圧気液平衡の推算
- CCD Photometry of a Newly Confirmed SU UMa-Type Dwarf Nova, NSV 4838
- 大学新入生における薬物乱用リスクと危険飲酒行動との関連
- Therapeutic Time Window of Cannabidiol Treatment on Delayed Ischemic Damage via High-Mobility Group Box1-Inhibiting Mechanism
- Optical and Near-Infrared Photometric Observation during the Superoutburst of the WZ Sge-Type Dwarf Nova, V455 Andromedae
- Spectral evolution of GRB 060904A observed with swift and Suzaku : Possibility of inefficient electron acceleration
- New Topics in Vasopressin Receptors and Approach to Novel Drugs : Role of the Vasopressin Receptor in Psychological and Cognitive Functions
- The Cannabinoid 1–Receptor Silent Antagonist O-2050 Attenuates Preference for High-Fat Diet and Activated Astrocytes in Mice
- Survey of Period Variations of Superhumps in SU UMa-Type Dwarf Novae
- 危険飲酒行動と薬物乱用リスクグループとの関連について : 大学新入生を対象とした調査より
- Neuroprotective Effects of Kangen-karyu on Spatial Memory Impairment in an 8-Arm Radial Maze and Neuronal Death in the Hippocampal CA1 Region Induced by Repeated Cerebral Ischemia in Rats
- Neuroprotective Effects of Quercetin and Rutin on Spatial Memory Impairment in an 8-Arm Radial Maze Task and Neuronal Death Induced by Repeated Cerebral Ischemia in Rats
- Differential Effects of Buckwheat and Kudingcha Extract on Neuronal Damage in Cultured Hippocampal Neurons and Spatial Memory Impairment Induced by Scopolamine in an Eight-Arm Radial Maze
- Determination of the Effectiveness of Components of the Herbal Medicine Toki-Shakuyaku-San and Fractions of Angelica acutiloba in Improving the Scopolamine-Induced Impairment of Rat's Spatial Cognition in Eight-Armed Radial Maze Test
- Protective Effect of Buckwheat Polyphenols Against Long-Lasting Impairment of Spatial Memory Associated With Hippocampal Neuronal Damage in Rats Subjected to Repeated Cerebral Ischemia
- Effect of Nilvadipine on the Cerebral Ischemia-Induced Impairment of Spatial Memory and Hippocampal Apoptosis in Rats
- Hypoxia Enhances β-Amyloid-Induced Apoptosis in Rat cultured Hippocampal Neurons
- 私の論文から Perospirone, a novel antipsychotic drug, reduces marble-burying behavior via 5-HT1A receptor in mice
- Suzaku Observations of the Great Annihilator and the Surrounding Diffuse Emissions
- Discovery of K-Shell Emission Lines of Neutral Atoms in the Galactic Center Region
- Optical and Near-Infrared Photometry of Nova V2362 Cyg : Rebrightening Event and Dust Formation
- Calcium-Channel Antagonists Inhibit Marble-Burying Behavior in Mice
- Cholinergic involvement in the improving effects of Yoku-kan-san-ka-chimpi-hange (Yi-Gan-San-Jia-Chen-Pi-Ban-Xia) on the disruption of spatial cognition and the electroconvulsive shock-induced immobilization
- The Scopolamine-Induced Impairment of Spatial Cognition Parallels the Acetylcholine Release in the Ventral Hippocampus in Rats
- Rolipram and Its Optical Isomers, Phosphodiesterase 4 Inhibitors, Attenuated the Scopolamine-Induced Impairments of Learning and Memory in Rats
- Anti-Correlation of Near-Infrared and X-Ray Variations of the Microquasar GRS 1915+105 in the Soft State
- The 2006 November Outburst of EG Aquarii : the SU UMa Nature Revealed
- P2-403 日本型がんチーム医療体制を構築するには(一般演題 ポスター発表,癌薬物療法(その他),臨床から学び臨床へと還元する医療薬学)
- Swift and Suzaku observations of the X-ray afterglow from the GRB 060105
- Protection by buckwheat polyphenols of cell death induced by glutamate and kainate in cultured hippocampal neurons
- 2,5-Dimethoxy-4-iodoamphetamine (DOI) Inhibits Δ^9-Tetrahydrocannabinol-Induced Catalepsy-Like Immobilization in Mice
- Spatial Memory Impairment Without Apoptosis Induced by the Combination of Beta-Amyloid Oligomers and Cerebral Ischemia Is Related to Decreased Acetylcholine Release in Rats
- Multiband Photopolarimetric Monitoring of an Outburst of the Blazar 3C 454.3 in 2007
- Dwarf Novae in the Shortest Orbital Period Regime. I A New Short Superhump Period Dwarf Nova, OT J055717+683226
- Effect of Low Dose Vitamin K2 (MK-4) Supplementation on Bio-Indices in Postmenopausal Japanese Women
- Effects of Intra-arterial Urokinase on a Non-human Primate Thromboembolic Stroke Model
- Tokishakuyakusan : Pharmacological evidence for neuroactive and neuroprotective actions
- Suzaku X-Ray and Optical Spectroscopic Observations of SS 433 in the 2006 April Multiwavelength Campaign
- Suzaku Observation Adjacent to the South End of the Radio Arc
- Effects of St John's Wort extracts on corticosterone levels dysregulated by social isolation stress
- Early Spectral Evolution of the Rapidly Expanding Type Ia Supernova 2006X
- Long-Term Monitoring of the Short Period SU UMa-Type Dwarf Nova, V844 Herculis
- Cerebral Acetylcholine Levels and Long-Term Spatial Cognitive Impairment Following Middle Cerebral Artery Occlusion in Rats
- The Pharmacological Characterization of Attentional Processes Using a Two-lever Choice Reaction Time Task in Rats
- Characteristics of Learning and Memory Impairment Induced by *^9-Tetrahydrocannabinol in Rats
- Bayesian Approach to Find a Long-Term Trend in Erratic Polarization Variations Observed in Blazars
- Discovery of a New Dwarf Nova, TSS J022216.4+412259.9 : WZ Sge-Type Dwarf Nova Breaking the Shortest Superhump Period Record
- The 2003/2004 Superoutburst of SDSS J013701.06-091234.9
- A New Candidate of a Cluster of Galaxies, 2XMM J045637.2+522411
- Spatial Distribution of the Galactic Center Diffuse X-Rays and the Spectra of the Brightest 6.4keV Clumps
- Time Variability of the Neutral Iron Lines from the Sagittarius B2 Region and Its Implication of a Past Outburst of Sagittarius A
- An X-Ray Face-On View of the Sagittarius B Molecular Clouds Observed with Suzaku
- A Super Bubble Candidate in the Galactic Center and a Local Enhancement G359.77-0.09
- Yokukansan Inhibits Social Isolation-Induced Aggression and Methamphetamine-Induced Hyperlocomotion in Rodents(Pharmacology)
- Involvement of GABA_A Receptors in the Neuroprotective Effect of Theanine on Focal Cerebral Ischemia in Mice
- Prenatal Exposure to 3,3',4,4',5-Pentachlorobiphenyl (PCB126) Promotes Anxiogenic Behavior in Rats
- Nilvadipine Prevents the Impairment of Spatial Memory Induced by Cerebral Ischemia Combined with β-Amyloid in Rats(Pharmacology)
- Comparison of Single- and Repeated-Ischemia-Induced Changes in Expression of Flip and Flop Splice Variants of AMPA Receptor Subtypes GluR1 and GluR2 in the Rats Hippocampus CA1 Subregion
- Perospirone, a Novel Antipsychotic Drug, Inhibits Marble-Burying Behavior via 5-HT_ Receptor in Mice : Implications for Obsessive-Compulsive Disorder
- PHARMACOLOGICAL CHARACTERISTICS OF ABNORMAL BEHAVIOR INDUCED BY HARMINE WITH SPECIAL REFERENCE TO TREMOR IN MICE
- Ectopic Neurons in the Hippocampus may be a Cause of Learning Disability after Prenatal Exposure to X-rays in Rats
- Role of Dopaminergic System in Core Part of Nucleus Accumbens in Hyperlocomotion and Rearing Induced by MK-801 in Rats : A Behavioral and In Vivo Microdialysis Study
- Reducing Acyl Migration during Purification of 2-Arachidonoylglycerol from Biological Samples before Gas Chromatography Mass Spectrometry Analysis
- New Perspectives in the Studies on Endocannabinoid and Cannabis : Abnormal Behaviors Associate With CB_1 Cannabinoid Receptor and Development of Therapeutic Application
- Yokukansan enhances pentobarbital-induced sleep in socially isolated mice: possible involvement of GABA[A]-benzodiazepine receptor complex
- Early Spectroscopy of the 2010 Outburst of U Scorpii
- Ameliorating effects of Kangen-karyu on neuronal damage in rats subjected to repeated cerebral ischemia
- The Effect of L-citrulline Ingestion on ECG QT Interval and Autonomic Nervous System Activity
- The Cannabinoid 1-Receptor Silent Antagonist O-2050 Attenuates Preference for High-Fat Diet and Activated Astrocytes in Mice
- Yokukansan Enhances Pentobarbital-Induced Sleep in Socially Isolated Mice: Possible Involvement of GABAA – Benzodiazepine Receptor Complex
- Neuroprotective Effects of Citidine-5-diphosphocholine on Impaired Spatial Memory in a Rat Model of Cerebrovascular Dementia
- Differential Role of Nucleus Accumbens and Gaudate-Putamen in Mediating the effect of Nomifensine and Methamphetamine on Ambulation and Rearing of Rats in the Open-Field Test
- Citidine-5-diphosphocholine Ameliorates the Impairment of Spatial Memory Induced by Scopolamine
- POSSIBLE INVOLVEMENT OF A CENTRAL NORADRENERGIC SYSTEM IN AUTOMUTILATION INDUCED BY CLONIDINE IN MICE
- A HAMILTONIAN SYSTEM ON THE FUCHSIAN MODULI SPACE(Algebraic Analysis and Number Theory)
- Effects of yokukansan on anxiety-like behavior in a rat model of cerebrovascular dementia
- Yokukansan Enhances Pentobarbital-Induced Sleep in Socially Isolated Mice : Possible Involvement of GABA_A-Benzodiazepine Receptor Complex
- Neuroprotective Effects of Citidine-5-diphosphocholine on Impaired Spatial Memory in a Rat Model of Cerebrovascular Dementia
- 強迫性障害の動物モデルであるマーブル・ベーリング行動に関する研究
- Role of 5-Hydroxytryptamine2C Receptors in Marble-Burying Behavior in Mice
- N-Acetyl-L-Cysteine Inhibits Marble-Burying Behavior in Mice
- Increasing Effect of an Oral Intake of L-Hydroxyproline on the Soluble Collagen Content of Skin and Collagen Fragments in Rat Serum
- 抑肝散の認知症に対する治療効果の行動薬理学的実証
- Ameliorative Effects of Telmisartan on the Inflammatory Response and Impaired Spatial Memory in a Rat Model of Alzheimer’s Disease Incorporating Additional Cerebrovascular Disease Factors
- Dietary Ornithine Affects the Tissue Protein Synthesis Rate in Young Rats
- Isolated periodic solutions to Painleve VI equation (Exact WKB Analysis and Microlocal Analysis)
- Effect of Dietary Ornithine on the Brain Protein Synthesis Rate in Hypophysectomized Aged Rats
- Effect of Nebracetam on the Disruption of Spatial Cognition in Rats.
- Scattering Theory for 4-th Order Differential Operators, I
- Effects of KW-5092, a Novel Gastroprokinetic Agent, on the Delayed Colonic Propulsion in Rats.
- Characterization of prussian blue analogs of the type M3(Fe(CN)5CO)2xH2O.