Neuroprotective Effect of Repeated Treatment with Hericium erinaceum in Mice Subjected to Middle Cerebral Artery Occlusion
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概要
- 論文の詳細を見る
The neuroprotective effects of Hericium erinaceum (H. erinaceum) were studied in mice subjected to middle cerebral artery (MCA) occlusion. Infarct volumes were markedly reduced in mice receiving 14 days of H. erinaceum (300 mg/kg) treatment prior to 4-hr MCA occlusion. Moreover, 14-day pre-ischemic H. erinaceum treatment significantly increased the levels of nerve growth factor (NGF) in both the cortex and striatum of mice subjected to 4-hr MCA occlusion. However, pre-ischemic H. erinaceum treatment had no effect on cerebral blood flow (CBF) in the cortex of mice subjected to MCA occlusion. Treatment with H. erinaceum for 1 day prior to MCA occlusion-induced ischemia had no effect on infarct volume or NGF level. These results suggest that 14 days of treatment with H. erinaceum prior to MCA occlusion protected against focal cerebral ischemia, by increasing NGF levels. This implies that H. erinaceum and its components could be useful for preventing cerebral infarction.
著者
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Hazekawa Mai
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Kataoka Aiko
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Hayakawa Kazuhide
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Uchimasu Takeshi
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Furuta Riyo
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Irie Keiichi
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Akitake Yoshiharu
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Yoshida Miyako
Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Mukogawa Womens University
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Fujioka Toshihiro
Department of Instrumental Analysis, Faculty of Pharmaceutical Sciences, Fukuoka University
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Egashira Nobuaki
Department of Pharmacy, Kyushu University Hospital
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Oishi Ryozo
Department of Pharmacy, Kyushu University Hospital
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Mishima Kenji
Department of Chemical Engineering, Fukuoka University
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Mishima Kenichi
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Uchida Takahiro
Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Mukogawa Womens University
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Iwasaki Katunori
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Fujiwara Michihiro
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Oishi Ryozo
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Irie Keiichi
Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Egashira Nobuaki
Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Hayakawa Kazuhide
Department Of Food Science And Technology National Fisheries University
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Fujioka Toshihiro
Department Of Instrumental Analysis Faculty Of Pharmaceutical Science Fukuoka University
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Mishima Kenichi
Department Of Chemical Engineering Faculty Of Engineering Fukuoka University
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Iwasaki Katunori
Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Fujiwara Michihiro
Department Of Neuroparmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Furuta Riyo
Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Akitake Yoshiharu
Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Mishima Kenji
Department Of Chemical Engineering Fukuoka University
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Iwasaki Katunori
Department Of Neuropharmacology Faculty Of Pharmaceutical Science Fukuoka University
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Yoshida Miyako
Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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Uchida Takahiro
Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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Fujioka Toshihiro
Department of Cardiovascular Disease, Yatsushiro Sogo Hospital
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Uchida Takahiro
Department of Cardiology, Tokyo Women's Medical University
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Hazekawa Mai
Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Japan
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