Comparison of Injuring Effects of Vesicant, Irritant, and Nonvesicant Anticancer Drugs on Endothelial Cells
スポンサーリンク
概要
- 論文の詳細を見る
Anticancer drugs are classified as vesicant, irritant, and nonvesicant drugs on the basis of frequency of their vascular disorder. In this study, we compared the injuring effects of three typical anticancer drugs of each class on porcine aorta endothelial cells (PAECs). The concentration inducing 50% cell viability inhibition was lower in the order of vesicant, irritant, and nonvesicant drugs. These results suggest that injuring effects of anticancer drugs on PAECs may be relevant as an indicator of frequency of their vascular disorder, and that this experimental model may be useful for the study of vascular disorder.
- 社団法人 日本薬理学会の論文
著者
-
Oishi Ryozo
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
-
Egashira Nobuaki
Dep. Of Pharmacy Kyushu Univ. Hospital
-
Egashira Nobuaki
Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
-
Yano Takahisa
Dep. Of Pharmacy Kyushu Univ. Hospital Jpn
-
Yamada Takaaki
Department Of Cardiology Nagoya University Graduate Of School Of Medicine
-
Yamada Takaaki
Department Of Pharmacy Kyushu University Hospital
-
Yano Takahisa
Department Of Pharmacy Kyushu University Hospital
-
Imuta Maiko
Department of Pharmacy, Kyushu University Hospital, Japan
-
Bando Ayami
Department of Pharmacy, Kyushu University Hospital, Japan
-
Saito Mami
Department of Pharmacy, Kyushu University Hospital, Japan
-
Imuta Maiko
Department Of Pharmacy Kyushu University Hospital
-
Bando Ayami
Department Of Pharmacy Kyushu University Hospital
関連論文
- Neuroprotective Effect of Repeated Treatment with Hericium erinaceum in Mice Subjected to Middle Cerebral Artery Occlusion
- P1-475 精神科外来におけるうつ病患者の唾液中ストレス関連物質の測定(一般演題 ポスター発表,薬物療法(精神科領域),医療薬学の創る未来 科学と臨床の融合)
- Delta(9)-tetrahydrocannabinol Enhances an Increase of Plasma Corticosterone Levels Induced by Forced Swim-Stress
- New Topics in Vasopressin Receptors and Approach to Novel Drugs : Role of the Vasopressin Receptor in Psychological and Cognitive Functions
- 大麻成分Δ^9-THCによる空間記憶障害におけるオピオイド受容体の関与
- 大麻成分 Δ^9-tetrahydrocannabinol による catalepsy 様不動状態に対するDOIの抑制作用
- 大学新入生における飲酒・喫煙・薬物乱用経験率の推移について
- Neuroprotective Effects of Kangen-karyu on Spatial Memory Impairment in an 8-Arm Radial Maze and Neuronal Death in the Hippocampal CA1 Region Induced by Repeated Cerebral Ischemia in Rats
- Neuroprotective Effects of Quercetin and Rutin on Spatial Memory Impairment in an 8-Arm Radial Maze Task and Neuronal Death Induced by Repeated Cerebral Ischemia in Rats
- Differential Effects of Buckwheat and Kudingcha Extract on Neuronal Damage in Cultured Hippocampal Neurons and Spatial Memory Impairment Induced by Scopolamine in an Eight-Arm Radial Maze
- Determination of the Effectiveness of Components of the Herbal Medicine Toki-Shakuyaku-San and Fractions of Angelica acutiloba in Improving the Scopolamine-Induced Impairment of Rat's Spatial Cognition in Eight-Armed Radial Maze Test
- Protective Effect of Buckwheat Polyphenols Against Long-Lasting Impairment of Spatial Memory Associated With Hippocampal Neuronal Damage in Rats Subjected to Repeated Cerebral Ischemia
- Effect of Nilvadipine on the Cerebral Ischemia-Induced Impairment of Spatial Memory and Hippocampal Apoptosis in Rats
- Hypoxia Enhances β-Amyloid-Induced Apoptosis in Rat cultured Hippocampal Neurons
- 私の論文から Perospirone, a novel antipsychotic drug, reduces marble-burying behavior via 5-HT1A receptor in mice
- 認知症の問題行動における漢方製剤の有用性--抑肝散の薬理を中心に (特集・中高年医療における漢方製剤の有用性とその根拠) -- (高齢者医療)
- Characteristics of Gabexate Mesilate–Induced Cell Injury in Porcine Aorta Endothelial Cells
- Calcium-Channel Antagonists Inhibit Marble-Burying Behavior in Mice
- Cholinergic involvement in the improving effects of Yoku-kan-san-ka-chimpi-hange (Yi-Gan-San-Jia-Chen-Pi-Ban-Xia) on the disruption of spatial cognition and the electroconvulsive shock-induced immobilization
- The Scopolamine-Induced Impairment of Spatial Cognition Parallels the Acetylcholine Release in the Ventral Hippocampus in Rats
- For Acute Myocardial Infarction, ST-segment Resolution is a Predictor of Remodeling or Clinical Prognosis after Percutaneous Coronary Intervention with Stents (Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 6 (IHD), The 69th Annual Scientific
- Effect of Intravenous Nicorandil before Reperfusion for Acute Myocardial Infarction in Patients with a Higher White Blood Cell Count(Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Ci
- Intravenous Nicorandil before Percutaneous Coronary Intervention Has Pharmacological Preconditioning Effects in Patients with Acute Myocardial Infarction(Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 12 (IHD), The 69th Annual Scientific Meet
- Long-term Clinical Outcomes after Myocardial Infarction in Stent Era for Patients with Diabetes Mellitus(Diabetes/Obesity 8 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Intravenous Nicorandil before Reperfusion Improves Epicardial Flow and Accelerates ST-Segment Resolution in Patients with Acute Myocardial Infarction(Clinical Trials in Ischemic Heart Disease (IHD), The 69th Annual Scientific Meeting of the Japanese Circu
- Protection by buckwheat polyphenols of cell death induced by glutamate and kainate in cultured hippocampal neurons
- 2,5-Dimethoxy-4-iodoamphetamine (DOI) Inhibits Δ^9-Tetrahydrocannabinol-Induced Catalepsy-Like Immobilization in Mice
- Spatial Memory Impairment Without Apoptosis Induced by the Combination of Beta-Amyloid Oligomers and Cerebral Ischemia Is Related to Decreased Acetylcholine Release in Rats
- Evaluation of Effectiveness of New Infusion Set Equipped with an In-line Filter
- Local Injection of Low Dose Recombinant Granulocyte-Colony Stimulating Factor Stimulates Ischemia-induced Angiogenesis(Angiogenesis 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Human Bone Marrow Derived Cells Differentiate into Endothelial or Smooth Muscle Lineage Cells Depending on Growth Factor Conditions in Culture(Atherosclerosis, Basic 10 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Tokishakuyakusan : Pharmacological evidence for neuroactive and neuroprotective actions
- PJ-621 The Role of Ca^/Calmodulin-Dependent Protein Kinase 2 in Spontaneous Hypertensive Rat Heart(Cardiac Hypertrophy, Basic and Clinical 2 (M) : PJ104)(Poster Session (Japanese))
- PE-233 Ca^-dependent Modulation of Intracellular Mg^Concentration with Amiloride and KB-R7943 in Pig Carotid Artery(Vascular Smooth Muscle 1 (H) : PE40)(Poster Session (English))
- The Pharmacological Characterization of Attentional Processes Using a Two-lever Choice Reaction Time Task in Rats
- Determination of salicylic acid in human serum with capillary zone electrophoresis
- Characteristics of Learning and Memory Impairment Induced by *^9-Tetrahydrocannabinol in Rats
- Clinical and Experimental Evidence for Prevention of Acute Renal Failure Induced by Radiographic Contrast Media
- Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs) : Role of Tryptase/PAR-2 in Vascular Endothelial Barrier Function
- Nafamostat Mesilate Is an Extremely Potent Inhibitor of Human Tryptase
- Potentiation of _L-Dopa-Induced Behavioral Excitement by Histamine H_1-Receptor Antagonists in Mice
- Yokukansan Inhibits Social Isolation-Induced Aggression and Methamphetamine-Induced Hyperlocomotion in Rodents(Pharmacology)
- Involvement of GABA_A Receptors in the Neuroprotective Effect of Theanine on Focal Cerebral Ischemia in Mice
- Prenatal Exposure to 3,3',4,4',5-Pentachlorobiphenyl (PCB126) Promotes Anxiogenic Behavior in Rats
- Nilvadipine Prevents the Impairment of Spatial Memory Induced by Cerebral Ischemia Combined with β-Amyloid in Rats(Pharmacology)
- Comparison of Single- and Repeated-Ischemia-Induced Changes in Expression of Flip and Flop Splice Variants of AMPA Receptor Subtypes GluR1 and GluR2 in the Rats Hippocampus CA1 Subregion
- Perospirone, a Novel Antipsychotic Drug, Inhibits Marble-Burying Behavior via 5-HT_ Receptor in Mice : Implications for Obsessive-Compulsive Disorder
- Enantioselective determination of thiamylal in human serum by high-performance liquid chromatography
- Role of Dopaminergic System in Core Part of Nucleus Accumbens in Hyperlocomotion and Rearing Induced by MK-801 in Rats : A Behavioral and In Vivo Microdialysis Study
- New Perspectives in the Studies on Endocannabinoid and Cannabis : Abnormal Behaviors Associate With CB_1 Cannabinoid Receptor and Development of Therapeutic Application
- Application of high-performance thin-layer chromatography for the detection of organophosphorus insecticides in human serum after acute poisoning
- Micellar electrokinetic capillary chromatography for therapeutic drug monitoring of zonisamide
- Enhancement by Morphine of Radiographic Contrast Media-Induced Histamine Release in Rat Peritoneal Mast Cells
- Protective Effects of Amino Acids Against Gabexate Mesilate-Induced Cell Injury in Porcine Aorta Endothelial Cells
- Characteristics of Gabexate Mesilate-Induced Cell Injury in Porcine Aorta Endothelial Cells
- In Vivo Evidence for a Lack of Central Effect of Ebastine, an Antihistaminic Agent, in Rats : a Microdialysis Study
- Ameliorating effects of Kangen-karyu on neuronal damage in rats subjected to repeated cerebral ischemia
- Yokukansan Enhances Pentobarbital-Induced Sleep in Socially Isolated Mice: Possible Involvement of GABAA – Benzodiazepine Receptor Complex
- Mexiletine Reverses Oxaliplatin-Induced Neuropathic Pain in Rats
- EFFECTS OF DELTA-9-TETRAHYDROCANNABINOL ON THE CARDIOVASCULAR SYSTEM, AND PRESSOR AND BEHAVIORAL RESPONSES TO BRAIN STIMULATION IN RATS
- Rapid and sensitive detection of benzodiazepines and zopiclone in serum using high-performance thin-layer chromatography
- Comparison of Peripheral Neuropathy Induced by Standard and Nanoparticle Albumin–Bound Paclitaxel in Rats
- Comparison of Injuring Effects of Vesicant, Irritant, and Nonvesicant Anticancer Drugs on Endothelial Cells
- CENTRAL CHOLINERGIC ACTIVATION BY CHLORFEN VINPHOS, AN ORGANOPHOSPHATE, IN THE RAT
- EFFECT OF DESIPRAMINE ON NORADRENERGIC INHIBITION OF AMYGDALOID EVOKED POTENTIAL
- EFFECT OF STIMULATION OF LOCUS COERULEUS ON THE EVOKED POTENTIAL IN THE AMYGDALA IN RATS
- THE ROLE OF THE LOCUS COERULEUS IN REGULATION OF SEIZURE SUSCEPTIBILITY IN RATS
- POSSIBLE INVOLVEMENT OF A CENTRAL NORADRENERGIC SYSTEM IN AUTOMUTILATION INDUCED BY CLONIDINE IN MICE
- Yokukansan Enhances Pentobarbital-Induced Sleep in Socially Isolated Mice : Possible Involvement of GABA_A-Benzodiazepine Receptor Complex
- Comparison of Injuring Effects of Vesicant, Irritant, and Nonvesicant Anticancer Drugs on Endothelial Cells
- うつ病患者における唾液中コルチゾールおよびDHEA濃度の測定
- Comparison of Peripheral Neuropathy Induced by Standard and Nanoparticle Albumin-Bound Paclitaxel in Rats
- 強迫性障害の動物モデルであるマーブル・ベーリング行動に関する研究
- Repeated Administration of Amitriptyline Reduces Oxaliplatin-Induced Mechanical Allodynia in Rats
- Role of 5-Hydroxytryptamine2C Receptors in Marble-Burying Behavior in Mice
- N-Acetyl-L-Cysteine Inhibits Marble-Burying Behavior in Mice
- Decrease in Venous Irritation by Adjusting the Concentration of Injected Bendamustine
- Sonoluminescence and bubble dynamics in viscous liquids
- Effect of microinjection of histamine into the brain on plasma levels of epinephrine and glucose in freely moving rats.
- Effects of isofloxythepin on central and peripheral histamine systems.
- Effectiveness and Safety of Antiemetic Aprepitant in Japanese Patients Receiving High-Dose Chemotherapy Prior to Autologous Hematopoietic Stem Cell Transplantation
- Effect of a New Psychoactive Compound, MCI-225, on Brain Monoamine Metabolism in Rats.
- Protective Effects of Amino Acids Against Gabexate Mesilate-Induced Cell Injury in Porcine Aorta Endothelial Cells
- Effect of acute treatment of mice with L-histidine on the brain levels of amino acids.
- Histamine turnover in the rat hypothalamic nuclei estimated from .ALPHA.-fluoromethylhistidine-induced histamine decrease.
- 9-Amino-1,2,3,4-Tetrahydroacridine Is a Potent Inhibitor of Histamine N-Methyltransferase.
- Effects of nociceptive stimuli on brain histamine dynamics.
- Effects of GABA-mimetic drugs on turnover of histamine in the mouse brain.