In Vivo Evidence for a Lack of Central Effect of Ebastine, an Antihistaminic Agent, in Rats : a Microdialysis Study
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概要
- 論文の詳細を見る
The effects of ebastine and its active metabolite carebastine on brain dopamine uptake and the accessibility to brain were compared with those for a classical antihistaminic agent chlorpheniramine by using the microdialysis technique. Both carebastine and chlorpheniramine potently inhibited brain [3H]dopamine uptake and increased the extracellular concentration of dopamine in the striatum after local perfusion via microdialysis probes, although systemic injection of ebastine but not chlorpheniramine did not change the dopamine level. These findings suggest that neither ebastine nor carebastine affects central dopamine metabolism because of a limited access to brain, in spite of having a potent inhibitory action on neuronal dopamine uptake.
- 社団法人 日本薬理学会の論文
- 2002-12-01
著者
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Oishi Ryozo
Department of Pharmacy, Kyushu University Hospital
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Oishi Ryozo
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Itoh Yoshinori
Department of Cardiovascular Medicine, Hokkaido University, Graduate School of Medicine
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FUJISAKI Yuko
Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University
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Itoh Yoshinori
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Itoh Yoshinori
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Fujisaki Yuko
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Itoh Yoshinori
Department Of Cardiorenal And Cerebrovascular Medicine Kagawa University
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