Effect of a New Psychoactive Compound, MCI-225, on Brain Monoamine Metabolism in Rats.
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概要
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Effect of MCI-225 on brain monoamine metabolism was examined in rats. MCI-225 (30 mg/kg, p.o.) had no influence on noradrenaline (NA) levels, but significantly inhibited the NA turnover in the hippocampus and hypothalamus. This compound also significantly increased the 5-hydroxyindoleacetic acid (5-HIAA)/5-hydroxytryptamine ratio in the cerebral cortex, hippocampus and striatum; and it enhanced the probenecid-induced 5-HIAA accumulation in the striatum. In the microdialysis study, MCI-225 markedly increased the NA output, but decreased the 3, 4-dihydroxyphenylethyleneglycol output from the hypothalamus of urethane-anesthetized rats. These results suggest that MCI-225 enhances both noradrenergic and serotonergic function by inhibiting NA uptake and accelerating 5-HT turnover, respectively.
- 公益社団法人 日本薬理学会の論文
著者
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Oishi Ryozo
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Saeki Kiyomi
Department Of Pharmacology Okayama University Medical School
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Adachi Naoto
Department of Anesthesiology and Resuscitology, Ehime University, School of Medicine
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Itoh Yoshinori
Nippon Shinyaku Research Laboratories
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