DISODIUM CROMOGLYCATE INHIBITION OF SUBSTANCE P-INDUCED HISTAMINE SECRETION IS CALCIUM DEPENDENT
スポンサーリンク
概要
- 論文の詳細を見る
Histamine secretion was induced by substance P, in a dose-dependent manner, from rat peritoneal mast cells, both in the presence and absence of Ca<SUP>2+</SUP> in the medium, and disodium cromoglycate (DSCG) produced a dose-dependent inhibition of the histamine secretion in Ca<SUP>2+</SUP>-containing medium. However, in the absence of Ca<SUP>2+</SUP>, DSCG was ineffective or had a far weaker activity. Mg<SUP>2+</SUP>, Sr<SUP>2+</SUP> and Ba<SUP>2+</SUP> were ineffective in restoring the DSCG activity when added to medium devoid of divalent metal ions. Therefore, extracellular Ca<SUP>2+</SUP> seems to be a specific requirement for the binding of DSCG to its “receptors” on the mast cell surface or some steps in the DSCG action.
- 社団法人 日本薬理学会の論文
著者
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NISHIBORI Masahiro
Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceu
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SAEKI Kiyomi
Department of Pharmacology, Okayama University Medical School
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Saeki Kiyomi
Department Of Pharmacology Okayama University Medical School
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Nishibori Masahiro
Department Of Pharmacology Okayama University Graduate School Of Medicine And Dentistry
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