Nafamostat Mesilate Is an Extremely Potent Inhibitor of Human Tryptase
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概要
- 論文の詳細を見る
Previously, nafamostat mesilate was found to be a potent inhibitor of human tryptase. In present study, we performed a kinetic study to determine its Ki value for tryptase and compared it with that of gabexate mesilate. Nafamostat mesilate inhibited human tryptase in a competitive manner. The apparent Ki value was estimated to be 95.3 pM, which was 1,000 times lower than that of gabexate mesilate (95.1 nM). These results strongly indicated that nafamostat mesilate is an extremely potent inhibitor of tryptase and suggested that some of its beneficial effects in the treatment of clinical status may be due to tryptase inhibition.
- 社団法人 日本薬理学会の論文
- 2003-08-01
著者
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Oishi Ryozo
Department of Pharmacy, Kyushu University Hospital
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Sendo Toshiaki
Dep. Of Hospital Pharmacy Okayama Univ. Medical School Jpn
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Sendo Toshiaki
岡山大学 医歯薬学総合研究科薬理学
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Sendo Toshiaki
Department Of Hospital Pharmacy Okayama University Medical And Dental School
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Sendoh Toshiaki
九州大学 薬
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Sendo T
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Sendo Toshiaki
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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NISHIBORI Masahiro
Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceu
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Oishi R
Dep. Of Pharmacy Kyushu Univ. Hospital Jpn
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Oishi Ryozo
Department Of Pharmacy Kyushu University Hospital
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Oishi Ryozo
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Itoh Yoshinori
Department of Cardiovascular Medicine, Hokkaido University, Graduate School of Medicine
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Itoh Yoshinori
九州大学病院 薬剤部
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Itoh Yoshinori
Department Of Cardiovascular Medicine Hokkaidou University Graduate School Of Medicine
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MORI Shuji
Department of Bacteriology, Fukushima Medical College
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Shinohata Ryoko
Department of Medical Technology, Okayama University Graduate School of Health Sciences
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Mori Shuji
Department Of Pharmacology Okayama University Graduate School Of Medicine And Dentistry
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Shinohata Ryoko
Department Of Pharmacology Okayama University Graduate School Of Medicine And Dentistry
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Mori Shuji
Department Of Bacteriology Fukushima Medical College
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Itoh Yoshinori
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Mori S
Department Of Pharmacology Okayama University Graduate School Of Medicine And Dentistry
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Shinohata Ryoko
Department Of Medical Technology Okayama University Graduate School Of Health Sciences
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Nishibori Masahiro
Department Of Pharmacology Okayama University Graduate School Of Medicine And Dentistry
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Itoh Yoshinori
Department Of Cardiorenal And Cerebrovascular Medicine Kagawa University
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Sendo Toshiaki
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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