Nicotinic Acetylcholine α4β2 Receptor Regulates the Motivational Effect of Intracranial Self Stimulation Behavior in the Runway Method
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概要
- 論文の詳細を見る
Recently, it was demonstrated that the priming stimulation effect (PSE) of intracranial self-stimulation (ICSS) with the runway method can be used as a model system to study the motivation that contributes to specific behaviors. It was postulated that these behaviors could be used to compare the effects of various drugs on the mechanism of motivation. In the present study, the influences of nicotine, methyllycaconitine (α7 nicotine-receptor antagonist), and dihydro-β-erythroidine (α4β2 nicotine-receptor antagonist) on motivation were examined using the runway method for ICSS. Electrodes were implanted into the medial forebrain bundle of Wistar rats. The rats ran to the goal lever to get the reward (50 – 200 μA, 0.2 ms, 60 Hz) and pretrial electric stimulation (priming stimulation) in the medial forebrain bundle was performed. The experiment measured the running time from the start box until the rat pressed the goal lever for the reward stimulation. Under these reward and priming stimulation conditions, nicotine (0.2 mg/kg) induced a significant increase in running speed. The nicotine receptor antagonist α4β2 rather than α7 showed a dose-dependent antagonistic action on the effect of nicotine on running speed. These results demonstrate that nicotine enhances the running speed towards the goal lever via α4β2 nicotinic receptors and suggest that α4β2 nicotinic receptors influence the brain mechanism of motivation.
- 社団法人 日本薬理学会の論文
- 2008-12-20
著者
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Sendo Toshiaki
Dep. Of Hospital Pharmacy Okayama Univ. Medical School Jpn
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Sendo Toshiaki
Department Of Hospital Pharmacy Okayama University Medical And Dental School
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Sagara Hidenori
Department Of Hospital Pharmacy Okayama University Medical School
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Sagara Hidenori
岡山大学 大学院医歯薬学総合研究科医薬管理学
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Sagara Hidenori
松山大学 医薬情報解析学
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Sagara Hidenori
岡山大学医学部附属病院 薬剤部
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Sagara Hidenori
岡山大学病院 薬剤部
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Sagara Hidenori
岡山大学 臨床薬剤学分野
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Gomita Yutaka
Dep. Of Hospital Pharmacy Okayama Univ. Medical School Jpn
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Gomita Yutaka
岡山大学 医歯薬学総合研究科医薬管理学
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Gomita Y
Okayama Univ. Medical School Okayama Jpn
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SUEMARU Katsuya
Division of Pharmacy, Ehime University Hospital
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ARAKI Hiroaki
Division of Pharmacy, Ehime University Hospital
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Gomita Y
Shujitsu Univ. School Of Pharmacy Okayama Jpn
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Araki H
Division Of Pharmacy Ehime University Hospital
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Araki Hiroaki
愛媛大学医学部附属病院 薬剤部
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Araki Hiroaki
Department Of Clinical Pharmacology And Pharmacy Brain Science Ehime University Graduate School Of M
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Araki Hiroaki
Ehime Univ. Graduate School Of Medicine Ehime Jpn
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Suemaru Katsuya
Department Of Clinical Pharmacology And Pharmacy Brain Science Ehime University Graduate School Of M
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Suemaru Katsuya
Division Of Pharmacy Ehime University Hospital
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KITAMURA Yoshihisa
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Sendo T
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Sendo Toshiaki
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Gomita Yutaka
Department Of Hospital Pharmacy
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Gomita Yutaka
吉備国際大学 保健科学部作業療法学科
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Gomita Yutaka
科研製薬総合研究所
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Araki H
Dep. Of Clinical Pharmacology And Pharmacy Brain Sci. Ehime Univ. Graduate School Of Medicine Jpn
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Araki Hiroaki
Division Of Pharmacy Ehime University Hospital
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YAE Tetsuji
Department of Pharmaceutical Information Sciences, Matsuyama University
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SHIBATA Kazuhiko
Department of Pharmaceutical Information Sciences, Matsuyama University
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GOMITA Yutaka
Shujitsu University
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Yae Tetsuji
Department Of Pharmaceutical Information Sciences Matsuyama University
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Gomita Y
Daiichi Coll. Pharmaceutical Sciences Fukuoka Jpn
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Shibata Kazuhiko
Department Of Hospital Pharmacy Okayama University Medical School
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Kitamura Yoshihisa
Department Of Neurobiology Kyoto Pharmaceutical University
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Kitamura Yoshihisa
Department Of Pharmaceutical Care And Health Science Graduate School Of Medicine Dentistry And Pharm
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Kawasaki Yoichi
Department Of Pharmacy Okayama University Hospital
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Gomita Yutaka
Shujitsu Univ. School Of Pharmacy
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Kitamura Yoshihisa
Department Of Pharmaceutical Care And Health Science Graduate School Of Medicine Dentistry And Pharm
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Araki Hiroaki
Division of Hospital Pharmacy, Ehime University Hospital
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Sendo Toshiaki
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Kitamura Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Japan
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KITAMURA Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
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