The Effect of Baclofen on Alterations in the Sleep Patterns Induced by Different Stressors in Rats
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概要
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We have previously reported that sleep patterns are significantly affected by both physical and psychological stress induced by a communication box; however, the mechanism by which stress alters sleep patterns was not established. In the present study, we investigated the role of γ-aminobutyric acid (GABA), acting through the GABAB receptor, on stress-induced changes in sleep patterns. Our results show that physical stress increased the total wakefulness time by increasing sleep latency and inhibiting both rapid eye movement (REM) and non rapid eye movement (NREM) sleep during a 6 h sleep–recording period. The GABAB agonist baclofen (20 pmol/2 μl) attenuated the effects of physical stress on sleep latency, total wakefulness, and NREM sleep, but not total REM sleep. In contrast, psychological stress enhanced total REM sleep and shortened REM sleep latency without altering other sleep patterns. The effect of psychological stress on total REM sleep was also reversed by baclofen. These results suggest that GABA via GABAB receptors may play a role in the regulation of specific sleep patterns by both physical and psychological stress.
- 2009-04-20
著者
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Araki H
Division Of Pharmacy Ehime University Hospital
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Araki Hiroaki
愛媛大学医学部附属病院 薬剤部
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Araki Hiroaki
Department Of Clinical Pharmacology And Pharmacy Brain Science Ehime University Graduate School Of M
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Suemaru Katsuya
Department Of Clinical Pharmacology And Pharmacy Brain Science Ehime University Graduate School Of M
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Suemaru Katsuya
Ehime Univ. Graduate School Of Medicine Ehime Jpn
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Araki H
Dep. Of Clinical Pharmacology And Pharmacy Brain Sci. Ehime Univ. Graduate School Of Medicine Jpn
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CUI Ranji
Department of Clinical Pharmacology and Pharmacy, Brain Science, Ehime University Graduate School of
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LI Bingjin
Department of Clinical Pharmacology and Pharmacy, Brain Science, Ehime University Graduate School of
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Shibata Kazuhiko
Department Of Hospital Pharmacy Okayama University Medical School
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Cui Ranji
Department Of Clinical Pharmacology And Pharmacy Brain Science Ehime University Graduate School Of M
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Li Bingjin
Department Of Clinical Pharmacology And Pharmacy Brain Science Ehime University Graduate School Of M
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