A Key Role of the Mammillary Body in Mediation of the Antianxiety Action of Zopiclone, a Cyclopyrrolone Derivative
スポンサーリンク
概要
- 論文の詳細を見る
The present study was designed to elucidate the brain site of the anticonflict action of zopiclone (ZOP), a cyclopyrrolone derivative, using the rat conflict procedure. ZOP at 10 μg/μl, bilaterally injected into the mammillary body (MB), produced a significant increase in the punished responses, with no change in the unpunished responses. There were no significant changes in these responses when ZOP was injected into the central amygdala, frontal cortex or dorsal hippocampus. Attention should be given to the possibility that the MB is the site of the anticonflict action of ZOP.
著者
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Tominaga Keiko
Department Of Physiology Osaka University
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Shibata Kazuhiko
Department Of Hospital Pharmacy Okayama University Medical School
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Ueki Showa
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyushu University
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Kataoka Yasufumi
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Yamashita Kimihiro
Department Of Developmental Genetics (h2) Graduate School Of Medicine Chiba University
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Miyazaki Akira
Department Of Biochemistry Faculty Of Medicine Showa University
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KATAOKA Yasufumi
Department of Pharmacology2, Nagasaki University School of Medicine
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YAMASHITA Kimihiro
Department of Pharmacology2, Nagasaki University School of Medicine
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SHIBATA Kazuhiko
Department of Pharmacology, Faculty of Pharmaceutical Sciences Kyushu University
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UEKI Showa
Department of Phamacology, Faculty of Pharmaceutical Sciences, Kyushu University
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TOMINAGA Keiko
Department of Pharmacology, Faculty of Pharmaceutical Sciences Kyushu University
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