Systemic Effects of Carteolol, a β-Adrenoceptor Antagonist in Stroke-Prone Spontaneously Hypertensive Rats
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概要
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The preventive effects of carteolol, a β-adrenoceptor antagonist, on secondary lesions were pathophysiologically examined in stroke-prone spontaneously hypertensive rats (SHRSP) from 8 to 30 weeks of age. Carteolol was added to the drinking water in doses of 0.005% (8 to 18 weeks of age) to 0.01% (19 to 30 weeks of age) (3.8 and 6.0 mg/kg/d, respectively). These animals gained significantly more weight than the untreated control SHRSP, and their heart rate was reduced from 14 weeks of age. Suppression of blood pressure rise was not definite, however, histology revealed prevention of the development or aggravation of secondary hypertension-related lesions, such as myocardial fibrosis, proliferative arteriolitis, necrotic arteriolitis and renal glomerular lesions. A decrease in nonesterified fatty acids in the serum was evident. Thus, carteolol has cardiac as well as renal protective effects, in the SHRSP.
- 公益社団法人日本薬学会の論文
著者
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OZAKI MASAYORI
Department of Pharmacology, Medical School, Nagoya City University
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Niwa Masami
Department Of Pharmacology 2:department Of Pathology 2 Nagasaki University School Of Medicine
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Niwa Masami
Department Of Pharmacology 1 Nagasaki University Medical School
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UCHIDA SHINJI
Department of Surgery, Kurume University School of Medicine
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YAMASHITA Kimihiro
Department of Pharmacology, Nagasaki University School of Medicine
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OHTA Hisashi
Department of Pharmacology 2
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SHIGEMATSU Kazuto
Department of Pharmacology 2
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OHKUBO Tatsunobu
Department of Pharmacology 2
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Ohta H
Nagasaki Univ. School Of Medicine Nagasaki Jpn
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Ohta Hisashi
Department Of Electronics Engineering Shibaura Institute Of Technology
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Uchida Shinji
Department Of Applied Chemistry Yokohama National University
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Uchida S
Nagasaki Univ. School Of Medicine Nagasaki Jpn
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Ozaki Masayori
Department Of Pharmacology 2:department Of Pathology 2 Nagasaki University School Of Medicine
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Yamashita Kimihiro
Department Of Developmental Genetics (h2) Graduate School Of Medicine Chiba University
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Ohkubo T
Department Of Pharmacology 2:department Of Pathology 2 Nagasaki University School Of Medicine
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Ohkubo Tatsunobu
Department Of Neuropsychiatry Nihon University School Of Medicine
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Shigematsu Kazuto
Department Of Pathology 2 Nagasaki University
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Shigematsu Kazuto
Department Of Pharmacology 2:department Of Pathology 2 Nagasaki University School Of Medicine
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Yamashita K
Faculty Of Pharmaceutical Sciences Kinki University
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OZAKI Masayori
Department of Pharmacology 2, Nagasaki University School of Medicine
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Ozaki Masayori
Department of Nutrition Science, Division of Applied Life Sciences, Graduate School of Integrated Science and Art, University of East Asia
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