HYPEREMOTIONALITY INDUCED BY LESIONS IN THE OLFACTORY SYSTEM OF THE RAT
スポンサーリンク
概要
- 論文の詳細を見る
In order to clarify the neural mechanisms underlying the hyperemotionality induced by bilateral olfactory bulb ablations in rats, changes in emotional behavior were measured after various parts of the secondary olfactory structures had been lesioned and olfactory bulb ablations had been carried out. When the anterior olfactory nuclei, lateral olfactory tracts and prepiriform cortices were bilaterally lesioned simultaneously with olfactory bulb ablations, many rats died from lack of food intake, while on the contrary, the rats with bilateral lesions in the olfactory tubercle, anterior olfactory nuclei and olfactory bulb developed marked hyperemotionality immediately after the lesioning. Hyperemotionality of the latter rats included not only hyperreactivity similar to that observed in the septal rat but also a muricide of 90% in incidence, which is similar to rats with olfactory bulb ablations. From these results, it can be concluded that changes in the activity of the olfactory tubercle were the most important for the development of hyperemotionality following bilateral ablations of the olfactory bulb in the rat.
- 社団法人 日本薬理学会の論文
著者
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Ueki Showa
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyushu University
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Ogawa Nobuya
Department Of Clinical Pharmacology Ehime University School Of Medicine
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NURIMOTO Seiichi
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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OGAWA Nobuya
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University
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NURIMOTO Seiichi
Biological Research Lab., Tanabe Seiyaku Co., Ltd.
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UEKI Showa
Department of Phamacology, Faculty of Pharmaceutical Sciences, Kyushu University
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